SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UKB_A_BEZA1301_0 (2-HYDROXY-6-OXO-7-ME THYLOCTA-2,4-DIENOAT E HYDROLASE)	5x5i	HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA (Escherichia coli)	4 / 6	LEU A 146 PHE A 149 ALA A 148 LEU A 134	None	1.03A	1ukbA-5x5iA: undetectable	1ukbA-5x5iA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_A_ACRA720_1 (ALPHA-AMYLASE, SUSG)	5x5i	HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA (Escherichia coli)	4 / 7	GLU A 11 LEU A 105 LYS A 22 ASN A 102	None	1.23A	3k8mA-5x5iA: undetectable	3k8mA-5x5iA: 8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_B_ACRB820_1 (ALPHA-AMYLASE, SUSG)	5x5i	HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA (Escherichia coli)	4 / 7	GLU A 11 LEU A 105 LYS A 22 ASN A 102	None	1.34A	3k8mB-5x5iA: undetectable	3k8mB-5x5iA: 8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_D_AERD601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	5x5i	HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA (Escherichia coli)	4 / 5	GLY A 51 ASP A 53 GLU A 58 VAL A 122	None	1.12A	4nkvD-5x5iA: undetectable	4nkvD-5x5iA: 12.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UKB_A_BEZA1301_0","2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE HYDROLASE","5x5i","HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA","Escherichia coli",4,"LEU A 146;PHE A 149;ALA A 148;LEU A 134","None","1.03A","1ukbA-5x5iA:undetectable","1ukbA-5x5iA:undetectable"],["3K8M_A_ACRA720_1","ALPHA-AMYLASE, SUSG","5x5i","HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA","Escherichia coli",4,"GLU A  11;LEU A 105;LYS A  22;ASN A 102","None","1.23A","3k8mA-5x5iA:undetectable","3k8mA-5x5iA:8.29"],["3K8M_B_ACRB820_1","ALPHA-AMYLASE, SUSG","5x5i","HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA","Escherichia coli",4,"GLU A  11;LEU A 105;LYS A  22;ASN A 102","None","1.34A","3k8mB-5x5iA:undetectable","3k8mB-5x5iA:8.29"],["4NKV_D_AERD601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","5x5i","HTH-TYPE TRANSCRIPTIONAL REGULATOR RCDA","Escherichia coli",4,"GLY A  51;ASP A  53;GLU A  58;VAL A 122","None","1.12A","4nkvD-5x5iA:undetectable","4nkvD-5x5iA:12.42"]]