SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.96A 1c9sN-5x5tA:
undetectable
1c9sO-5x5tA:
undetectable		 1c9sN-5x5tA:
10.44
1c9sO-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.96A 1c9sP-5x5tA:
undetectable
1c9sQ-5x5tA:
undetectable		 1c9sP-5x5tA:
10.44
1c9sQ-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 9 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.94A 1c9sQ-5x5tA:
undetectable
1c9sR-5x5tA:
undetectable		 1c9sQ-5x5tA:
10.44
1c9sR-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.94A 1c9sL-5x5tA:
undetectable
1c9sV-5x5tA:
undetectable		 1c9sL-5x5tA:
10.44
1c9sV-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 9 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.91A 1gtfD-5x5tA:
undetectable
1gtfE-5x5tA:
undetectable		 1gtfD-5x5tA:
10.44
1gtfE-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.88A 1gtfJ-5x5tA:
undetectable
1gtfK-5x5tA:
undetectable		 1gtfJ-5x5tA:
10.44
1gtfK-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.95A 1gtfQ-5x5tA:
undetectable
1gtfR-5x5tA:
undetectable		 1gtfQ-5x5tA:
10.44
1gtfR-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 9 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.95A 1gtfR-5x5tA:
undetectable
1gtfS-5x5tA:
undetectable		 1gtfR-5x5tA:
10.44
1gtfS-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.95A 1gtfS-5x5tA:
undetectable
1gtfT-5x5tA:
undetectable		 1gtfS-5x5tA:
10.44
1gtfT-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.93A 1gtnT-5x5tA:
undetectable
1gtnU-5x5tA:
undetectable		 1gtnT-5x5tA:
10.44
1gtnU-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.95A 1gtnL-5x5tA:
undetectable
1gtnV-5x5tA:
undetectable		 1gtnL-5x5tA:
10.44
1gtnV-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		3 / 3 ALA A  67
VAL A  65
TRP A  62
 None
 0.84A 1nt5A-5x5tA:
undetectable		 1nt5A-5x5tA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		3 / 3 ALA A  67
VAL A  65
TRP A  62
 None
 0.84A 1nt5B-5x5tA:
undetectable		 1nt5B-5x5tA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 ALA A 401
LEU A 294
ILE A 438
GLY A 414
LEU A 431
 None
 0.99A 1qknA-5x5tA:
undetectable		 1qknA-5x5tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 5 MET A  74
ALA A  78
ILE A 114
ASP A 119
 None
 1.00A 1upfA-5x5tA:
undetectable		 1upfA-5x5tA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 5 MET A  74
ALA A  78
ILE A 114
ASP A 119
 None
 0.95A 1upfC-5x5tA:
undetectable		 1upfC-5x5tA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.90A 1utdE-5x5tA:
undetectable
1utdF-5x5tA:
undetectable		 1utdE-5x5tA:
10.44
1utdF-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.87A 1utdH-5x5tA:
undetectable
1utdI-5x5tA:
undetectable		 1utdH-5x5tA:
10.44
1utdI-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.93A 1utdL-5x5tA:
undetectable
1utdM-5x5tA:
undetectable		 1utdL-5x5tA:
10.44
1utdM-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.92A 1utdO-5x5tA:
undetectable
1utdP-5x5tA:
undetectable		 1utdO-5x5tA:
10.44
1utdP-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.91A 1utdP-5x5tA:
undetectable
1utdQ-5x5tA:
undetectable		 1utdP-5x5tA:
10.44
1utdQ-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.92A 1utdS-5x5tA:
undetectable
1utdT-5x5tA:
undetectable		 1utdS-5x5tA:
10.44
1utdT-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 356
ALA A 345
THR A 369
ILE A 352
GLY A 387
 None
 0.95A 1utdU-5x5tA:
undetectable
1utdV-5x5tA:
undetectable		 1utdU-5x5tA:
10.44
1utdV-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.92A 1utdL-5x5tA:
undetectable
1utdV-5x5tA:
undetectable		 1utdL-5x5tA:
10.44
1utdV-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		3 / 3 ASP A  47
ARG A  50
ASP A  19
 None
 0.95A 1vptA-5x5tA:
undetectable		 1vptA-5x5tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 THR A 152
ILE A  13
ASP A  47
ALA A  43
ASP A  14
 None
 1.28A 2admA-5x5tA:
undetectable		 2admA-5x5tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		3 / 3 LYS A 279
ARG A 292
VAL A 260
 None
 1.05A 2r2vC-5x5tA:
undetectable
2r2vD-5x5tA:
undetectable		 2r2vC-5x5tA:
6.17
2r2vD-5x5tA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 PHE A 366
LEU A 314
SER A 351
ARG A 346
GLU A 353
 None
 1.26A 2vdmA-5x5tA:
undetectable
2vdmB-5x5tA:
2.1		 2vdmA-5x5tA:
21.30
2vdmB-5x5tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 8 THR A 418
ILE A 261
ASP A 265
SER A 420
 None
 1.08A 2xytE-5x5tA:
undetectable		 2xytE-5x5tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 8 THR A 418
ILE A 261
ASP A 265
SER A 420
 None
 1.00A 2xytH-5x5tA:
undetectable		 2xytH-5x5tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 7 THR A 418
ILE A 261
ASP A 265
SER A 420
 None
 1.04A 2xytI-5x5tA:
undetectable		 2xytI-5x5tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 6 THR A   9
THR A   7
SER A 186
LEU A  91
 None
 0.92A 3deuB-5x5tA:
undetectable		 3deuB-5x5tA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		3 / 3 ALA A  67
VAL A  65
TRP A  62
 None
 0.81A 3l8lC-5x5tA:
undetectable
3l8lD-5x5tA:
undetectable		 3l8lC-5x5tA:
4.08
3l8lD-5x5tA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 11 ILE A 392
ILE A 299
VAL A 295
PHE A 293
VAL A 262
 None
 1.14A 3rf4A-5x5tA:
undetectable
3rf4B-5x5tA:
undetectable		 3rf4A-5x5tA:
12.28
3rf4B-5x5tA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 6 LEU A 176
ALA A 179
THR A 152
LEU A 191
 None
 1.00A 3t3zA-5x5tA:
undetectable		 3t3zA-5x5tA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 PHE A 156
PRO A 153
THR A 230
GLU A 253
PHE A 450
 None
 1.50A 4k88A-5x5tA:
3.0		 4k88A-5x5tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 9 PHE A 280
ALA A 306
LEU A 307
GLY A 276
ALA A 378
 None
 1.46A 4l6va-5x5tA:
undetectable
4l6vf-5x5tA:
undetectable		 4l6va-5x5tA:
20.78
4l6vf-5x5tA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 8 ALA A  54
GLY A 202
ALA A 201
GLY A  15
 None
 0.68A 4zjzA-5x5tA:
undetectable		 4zjzA-5x5tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5eevA-5x5tA:
undetectable
5eevB-5x5tA:
undetectable		 5eevA-5x5tA:
10.44
5eevB-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5eewA-5x5tA:
undetectable
5eewB-5x5tA:
undetectable		 5eewA-5x5tA:
10.44
5eewB-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5eexA-5x5tA:
undetectable
5eexB-5x5tA:
undetectable		 5eexA-5x5tA:
10.44
5eexB-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5eeyA-5x5tA:
undetectable
5eeyB-5x5tA:
undetectable		 5eeyA-5x5tA:
10.44
5eeyB-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5eezA-5x5tA:
undetectable
5eezB-5x5tA:
undetectable		 5eezA-5x5tA:
10.44
5eezB-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5ef0A-5x5tA:
undetectable
5ef0B-5x5tA:
undetectable		 5ef0A-5x5tA:
10.44
5ef0B-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5ef1A-5x5tA:
undetectable
5ef1B-5x5tA:
undetectable		 5ef1A-5x5tA:
10.44
5ef1B-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5ef2A-5x5tA:
undetectable
5ef2B-5x5tA:
undetectable		 5ef2A-5x5tA:
10.44
5ef2B-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.90A 5ef3A-5x5tA:
undetectable
5ef3B-5x5tA:
undetectable		 5ef3A-5x5tA:
10.44
5ef3B-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 VAL A 148
PHE A 175
ARG A  63
VAL A 124
LEU A 471
 None
 1.10A 5ergB-5x5tA:
4.1		 5ergB-5x5tA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		4 / 7 VAL A 140
SER A 475
VAL A 129
ARG A 127
 None
 0.95A 5fpdA-5x5tA:
undetectable		 5fpdA-5x5tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 12 LEU A 190
ILE A 204
GLU A 461
ALA A 167
LEU A 169
 None
 1.07A 5ienA-5x5tA:
undetectable		 5ienA-5x5tA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE
(Azospirillum
brasilense) 		5 / 10 GLY A 202
GLY A  58
LEU A 218
LEU A  52
ALA A  51
 None
 1.08A 5vm8B-5x5tA:
undetectable		 5vm8B-5x5tA:
20.48