SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 5x5v GD
(Suid
alphaherpesvirus
1) 		5 / 11 PRO A 132
MET A 133
MET A 218
THR A 131
THR A  36
 None
 1.50A 2uvnB-5x5vA:
undetectable		 2uvnB-5x5vA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5x5v GD
(Suid
alphaherpesvirus
1) 		3 / 3 TYR A 238
VAL A  68
THR A 244
 None
 0.56A 2ygnA-5x5vA:
undetectable		 2ygnA-5x5vA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5x5v GD
(Suid
alphaherpesvirus
1) 		3 / 3 ARG A 166
VAL A  69
THR A  59
 None
 0.68A 3cyxA-5x5vA:
undetectable		 3cyxA-5x5vA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5x5v GD
(Suid
alphaherpesvirus
1) 		5 / 12 GLN A  76
ASP A 147
LEU A 152
SER A  73
ALA A  70
 None
 1.29A 3d91A-5x5vA:
undetectable		 3d91A-5x5vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5x5v GD
(Suid
alphaherpesvirus
1) 		4 / 5 GLN A 226
THR A 131
THR A 136
HIS A 230
 None
 1.42A 3g1uC-5x5vA:
undetectable		 3g1uC-5x5vA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5x5v GD
(Suid
alphaherpesvirus
1) 		3 / 3 LEU A 109
TRP A  98
GLY A 150
 None
 0.75A 3l35A-5x5vA:
undetectable
3l35H-5x5vA:
undetectable		 3l35A-5x5vA:
5.72
3l35H-5x5vA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5x5v GD
(Suid
alphaherpesvirus
1) 		3 / 3 LEU A 109
TRP A  98
GLY A 150
 None
 0.74A 3l35B-5x5vA:
undetectable
3l35K-5x5vA:
undetectable		 3l35B-5x5vA:
5.72
3l35K-5x5vA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5x5v GD
(Suid
alphaherpesvirus
1) 		5 / 12 LEU A  71
LEU A 151
SER A 138
VAL A 181
LEU A  62
 None
 1.20A 3m7rA-5x5vA:
undetectable		 3m7rA-5x5vA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5x5v GD
(Suid
alphaherpesvirus
1) 		4 / 4 LEU A 176
ILE A 101
GLY A  52
PHE A  50
 None
 1.05A 4dc3A-5x5vA:
undetectable		 4dc3A-5x5vA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5x5v GD
(Suid
alphaherpesvirus
1) 		4 / 6 TYR A 141
PRO A 156
PHE A 202
ARG A 100
 None
 1.21A 4kf9A-5x5vA:
undetectable		 4kf9A-5x5vA:
25.06