SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 142
GLY A 160
GLY A 226
SER A 227
LEU A 156
 None
 0.74A 1i9gA-5x62A:
9.6		 1i9gA-5x62A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 352
LEU A 356
THR A 289
TYR A 286
ILE A 277
 None
 1.17A 1mx8A-5x62A:
undetectable		 1mx8A-5x62A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 287
ILE A 290
ALA A 352
ILE A 391
 None
 0.96A 1oniB-5x62A:
undetectable
1oniC-5x62A:
undetectable		 1oniB-5x62A:
16.26
1oniC-5x62A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 110
GLU A 120
ASN A 125
 None
 0.94A 2y7hC-5x62A:
7.9		 2y7hC-5x62A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 136
ALA A 140
GLY A 160
MET A 159
VAL A 270
 None
 1.10A 3f8wA-5x62A:
undetectable		 3f8wA-5x62A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 136
ALA A 140
GLY A 160
MET A 159
VAL A 270
 None
 1.10A 3f8wC-5x62A:
undetectable		 3f8wC-5x62A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 196
ALA A  65
ILE A  66
ASN A  69
 None
 0.98A 3fxrA-5x62A:
undetectable		 3fxrA-5x62A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 336
THR A 318
GLY A 315
HIS A 250
SER A 281
 None
 1.13A 3mg02-5x62A:
undetectable
3mg0V-5x62A:
undetectable		 3mg02-5x62A:
20.05
3mg0V-5x62A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 150
LEU A 152
LEU A 153
ILE A 144
 None
 0.83A 3nbqB-5x62A:
undetectable		 3nbqB-5x62A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 150
LEU A 152
LEU A 153
ILE A 144
 None
 0.89A 3nbqC-5x62A:
undetectable		 3nbqC-5x62A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 111
GLN A 108
GLY A 146
GLY A 148
SER A 234
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.2A)
SAH  A 501 ( 3.7A)
SAH  A 501 (-3.6A)
 1.29A 3sxjA-5x62A:
13.2		 3sxjA-5x62A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 111
GLN A 108
GLY A 146
GLY A 148
SER A 234
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.2A)
SAH  A 501 ( 3.7A)
SAH  A 501 (-3.6A)
 1.28A 3sxjB-5x62A:
13.3		 3sxjB-5x62A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 111
GLN A 108
GLY A 146
GLY A 148
SER A 234
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.2A)
SAH  A 501 ( 3.7A)
SAH  A 501 (-3.6A)
 1.24A 3t7sB-5x62A:
13.2		 3t7sB-5x62A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 111
GLN A 108
GLY A 146
GLY A 148
SER A 234
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.2A)
SAH  A 501 ( 3.7A)
SAH  A 501 (-3.6A)
 1.21A 3t7sD-5x62A:
13.0		 3t7sD-5x62A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 302
TRP A 300
ASP A 278
 None
 1.31A 4a7tA-5x62A:
undetectable
4a7tF-5x62A:
undetectable		 4a7tA-5x62A:
18.28
4a7tF-5x62A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 274
LEU A 152
ARG A 121
SER A 126
 SAH  A 501 (-3.2A)
None
None
None
 0.93A 4cp3A-5x62A:
undetectable
4cp3B-5x62A:
undetectable		 4cp3A-5x62A:
16.34
4cp3B-5x62A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 391
ILE A 349
PHE A 358
GLY A 291
 None
 0.96A 4hdlA-5x62A:
undetectable		 4hdlA-5x62A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 286
THR A 279
PHE A 168
PHE A 310
 None
SAH  A 501 (-3.6A)
SAH  A 501 (-3.5A)
None
 1.15A 4kf9A-5x62A:
undetectable		 4kf9A-5x62A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 371
GLN A 108
SER A 104
ASP A 313
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
None
None
 1.38A 4qtuB-5x62A:
13.8		 4qtuB-5x62A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 4qvlV-5x62A:
undetectable
4qvlb-5x62A:
undetectable		 4qvlV-5x62A:
18.34
4qvlb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 4qvlH-5x62A:
undetectable
4qvlN-5x62A:
undetectable		 4qvlH-5x62A:
18.34
4qvlN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 4qvmV-5x62A:
undetectable
4qvmb-5x62A:
undetectable		 4qvmV-5x62A:
18.34
4qvmb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 4qvmH-5x62A:
undetectable
4qvmN-5x62A:
undetectable		 4qvmH-5x62A:
18.34
4qvmN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.21A 4qvnV-5x62A:
undetectable
4qvnb-5x62A:
undetectable		 4qvnV-5x62A:
18.34
4qvnb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.21A 4qvnH-5x62A:
undetectable
4qvnN-5x62A:
undetectable		 4qvnH-5x62A:
18.34
4qvnN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.19A 4qvpV-5x62A:
undetectable
4qvpb-5x62A:
undetectable		 4qvpV-5x62A:
18.34
4qvpb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.19A 4qvpH-5x62A:
undetectable
4qvpN-5x62A:
undetectable		 4qvpH-5x62A:
18.34
4qvpN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.20A 4qvqV-5x62A:
undetectable
4qvqb-5x62A:
undetectable		 4qvqV-5x62A:
18.34
4qvqb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.21A 4qvqH-5x62A:
undetectable
4qvqN-5x62A:
undetectable		 4qvqH-5x62A:
18.34
4qvqN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.15A 4qvwV-5x62A:
undetectable
4qvwb-5x62A:
undetectable		 4qvwV-5x62A:
18.34
4qvwb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.15A 4qvwH-5x62A:
undetectable
4qvwN-5x62A:
undetectable		 4qvwH-5x62A:
18.34
4qvwN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 4qw0V-5x62A:
undetectable
4qw0b-5x62A:
undetectable		 4qw0V-5x62A:
18.34
4qw0b-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 4qw0H-5x62A:
undetectable
4qw0N-5x62A:
undetectable		 4qw0H-5x62A:
18.34
4qw0N-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 4qw1V-5x62A:
undetectable
4qw1b-5x62A:
undetectable		 4qw1V-5x62A:
18.34
4qw1b-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 4qw1H-5x62A:
undetectable
4qw1N-5x62A:
undetectable		 4qw1H-5x62A:
18.34
4qw1N-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.18A 4qw3V-5x62A:
undetectable
4qw3b-5x62A:
undetectable		 4qw3V-5x62A:
18.34
4qw3b-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 4qw3H-5x62A:
undetectable
4qw3N-5x62A:
undetectable		 4qw3H-5x62A:
18.34
4qw3N-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.19A 4qwuV-5x62A:
undetectable
4qwub-5x62A:
undetectable		 4qwuV-5x62A:
18.34
4qwub-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.19A 4qwuH-5x62A:
undetectable
4qwuN-5x62A:
undetectable		 4qwuH-5x62A:
18.34
4qwuN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 368
TYR A 385
PRO A 383
GLU A 120
 None
 0.88A 4z4fA-5x62A:
undetectable		 4z4fA-5x62A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 368
TYR A 385
PRO A 383
GLU A 120
 None
 1.00A 4z4gA-5x62A:
undetectable		 4z4gA-5x62A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 273
PHE A 276
ILE A 277
PHE A 235
LEU A 356
 None
 1.31A 4ze0A-5x62A:
undetectable		 4ze0A-5x62A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.20A 5bxnV-5x62A:
undetectable
5bxnb-5x62A:
undetectable		 5bxnV-5x62A:
18.34
5bxnb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.21A 5bxnH-5x62A:
undetectable
5bxnN-5x62A:
undetectable		 5bxnH-5x62A:
18.34
5bxnN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 5cz7H-5x62A:
undetectable
5cz7N-5x62A:
undetectable		 5cz7H-5x62A:
18.34
5cz7N-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 5d0xV-5x62A:
undetectable
5d0xb-5x62A:
undetectable		 5d0xV-5x62A:
18.34
5d0xb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 5d0xH-5x62A:
undetectable
5d0xN-5x62A:
undetectable		 5d0xH-5x62A:
18.34
5d0xN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 5l5zV-5x62A:
undetectable
5l5zb-5x62A:
undetectable		 5l5zV-5x62A:
18.34
5l5zb-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.16A 5l5zH-5x62A:
undetectable
5l5zN-5x62A:
undetectable		 5l5zH-5x62A:
18.34
5l5zN-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 5l66V-5x62A:
undetectable
5l66b-5x62A:
undetectable		 5l66V-5x62A:
18.34
5l66b-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.17A 5l66H-5x62A:
undetectable
5l66N-5x62A:
undetectable		 5l66H-5x62A:
18.34
5l66N-5x62A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 368
TYR A 385
PRO A 383
GLU A 120
 None
 0.89A 5t7bA-5x62A:
undetectable		 5t7bA-5x62A:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		10 / 12 GLY A 146
GLY A 148
ASN A 166
SER A 169
MET A 172
PHE A 235
PHE A 275
THR A 279
TYR A 286
TYR A 371
 SAH  A 501 (-3.2A)
SAH  A 501 ( 3.7A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.4A)
SAH  A 501 (-3.9A)
None
None
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.8A)
 0.32A 5yf0A-5x62A:
38.7		 5yf0A-5x62A:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF0_B_SAMB503_0
(CARNOSINE
N-METHYLTRANSFERASE)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		10 / 12 GLN A 108
GLY A 146
ASN A 166
SER A 169
MET A 172
PHE A 235
PHE A 275
THR A 279
TYR A 286
TYR A 371
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.2A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.4A)
SAH  A 501 (-3.9A)
None
None
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.8A)
 0.34A 5yf0B-5x62A:
39.7		 5yf0B-5x62A:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 100
LYS A 101
SER A 104
 None
 0.69A 6az3P-5x62A:
undetectable		 6az3P-5x62A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  97
VAL A 175
PHE A  73
PHE A  72
 None
 0.96A 6h7lA-5x62A:
2.9		 6h7lA-5x62A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  97
VAL A 175
PHE A  73
PHE A  72
 None
 0.97A 6h7lB-5x62A:
undetectable		 6h7lB-5x62A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.21A 6hwdV-5x62A:
undetectable
6hwdb-5x62A:
undetectable		 6hwdV-5x62A:
11.23
6hwdb-5x62A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5x62 CARNOSINE
N-METHYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 250
SER A 281
THR A 336
THR A 318
GLY A 315
 None
 1.22A 6hwdH-5x62A:
undetectable
6hwdN-5x62A:
undetectable		 6hwdH-5x62A:
11.23
6hwdN-5x62A:
11.25