SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		4 / 7 VAL A  19
CYH A 139
CYH A 324
ARG A 349
 FAD  A 401 (-3.5A)
MLY  A 138 ( 4.3A)
None
None
 1.07A 1t46A-5x68A:
undetectable		 1t46A-5x68A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		5 / 11 ILE A 215
ALA A 225
LEU A 197
ILE A 199
PHE A 261
 None
 1.27A 1uduA-5x68A:
undetectable		 1uduA-5x68A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		5 / 12 SER A  53
GLY A  17
VAL A  19
MET A 317
ASN A 115
 FAD  A 401 ( 4.1A)
FAD  A 401 (-3.5A)
FAD  A 401 (-3.5A)
FAD  A 401 (-4.7A)
None
 1.39A 3f8wB-5x68A:
undetectable		 3f8wB-5x68A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		4 / 4 LYS A  53
SER A 232
LEU A  56
SER A 108
 None
None
FAD  A 401 (-4.1A)
None
 1.45A 3ik6H-5x68A:
undetectable		 3ik6H-5x68A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		4 / 6 ILE A  34
ASP A 304
GLY A  15
VAL A 300
 None
FAD  A 401 (-2.6A)
FAD  A 401 (-3.5A)
None
 0.87A 3n3iA-5x68A:
undetectable		 3n3iA-5x68A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		4 / 8 ASP A 332
SER A 335
ASN A 336
ARG A  30
 None
 0.94A 4af0A-5x68A:
undetectable		 4af0A-5x68A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		5 / 12 VAL A 300
ALA A 306
PHE A  26
LEU A  27
VAL A 164
 None
 1.16A 4eckB-5x68A:
undetectable		 4eckB-5x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		4 / 4 CYH A  25
PHE A  26
ILE A  75
GLY A  70
 None
 1.14A 5hesB-5x68A:
undetectable		 5hesB-5x68A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		6 / 10 LEU A  22
GLY A 303
VAL A 326
LEU A 325
ARG A  61
ALA A  65
 None
FAD  A 401 (-3.4A)
None
None
None
None
 1.15A 5o96E-5x68A:
undetectable
5o96F-5x68A:
undetectable		 5o96E-5x68A:
undetectable
5o96F-5x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		5 / 10 TYR A 364
ILE A 215
ILE A 224
LEU A 226
ILE A  97
 None
 1.11A 5vkqA-5x68A:
undetectable
5vkqD-5x68A:
undetectable		 5vkqA-5x68A:
undetectable
5vkqD-5x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		5 / 10 ILE A  97
TYR A 364
ILE A 215
ILE A 224
LEU A 226
 None
 1.10A 5vkqA-5x68A:
undetectable
5vkqB-5x68A:
undetectable		 5vkqA-5x68A:
undetectable
5vkqB-5x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		5 / 10 ILE A  97
TYR A 364
ILE A 215
ILE A 224
LEU A 226
 None
 1.11A 5vkqC-5x68A:
undetectable
5vkqD-5x68A:
undetectable		 5vkqC-5x68A:
undetectable
5vkqD-5x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens) 		4 / 7 GLN A 315
GLY A 303
GLY A 320
VAL A  19
 FAD  A 401 (-4.3A)
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.5A)
 0.93A 6ekzA-5x68A:
undetectable		 6ekzA-5x68A:
17.86