SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		3 / 3 CYH B  65
CYH B 110
HIS B 127
 ZN  B 201 (-3.0A)
ZN  B 201 (-2.1A)
ZN  B 201 (-3.0A)
 0.61A 2iwkA-5x6mB:
undetectable		 2iwkA-5x6mB:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		3 / 3 CYH B  65
CYH B 110
HIS B 127
 ZN  B 201 (-3.0A)
ZN  B 201 (-2.1A)
ZN  B 201 (-3.0A)
 0.57A 2iwkB-5x6mB:
undetectable		 2iwkB-5x6mB:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		3 / 3 CYH B  65
CYH B 110
HIS B 127
 ZN  B 201 (-3.0A)
ZN  B 201 (-2.1A)
ZN  B 201 (-3.0A)
 0.60A 3dtuB-5x6mB:
undetectable		 3dtuB-5x6mB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		3 / 3 CYH B  65
CYH B 110
HIS B 127
 ZN  B 201 (-3.0A)
ZN  B 201 (-2.1A)
ZN  B 201 (-3.0A)
 0.61A 3dtuD-5x6mB:
undetectable		 3dtuD-5x6mB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		4 / 7 TYR B 126
VAL B  39
VAL B  92
ILE B 123
 None
 1.31A 3ms9B-5x6mB:
undetectable		 3ms9B-5x6mB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		4 / 7 VAL B 121
ILE B  68
LEU B  56
LEU B  52
 None
 0.93A 4l1wA-5x6mB:
undetectable		 4l1wA-5x6mB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5x6m MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 5
(Mus
musculus) 		5 / 12 GLY B  74
GLY B  83
ARG B  91
GLY B 115
HIS B 101
 None
 0.95A 5hikA-5x6mB:
undetectable		 5hikA-5x6mB:
18.56