SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3A_A_TACA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	5x6n	DUFFY BINDING PROTEIN (Plasmodium knowlesi)	5 / 12	LEU A 87 ASN A 95 PHE A 98 ARG A 165 ILE A 175	None	1.35A	4b3aA-5x6nA: 2.4	4b3aA-5x6nA: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	5x6n	DUFFY BINDING PROTEIN (Plasmodium knowlesi)	3 / 3	GLU A 194 TRP A 27 LYS A 100	None None SO4 A 502 (-2.4A)	1.48A	4k7aA-5x6nA: undetectable	4k7aA-5x6nA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_A_NOVA2000_1 (DNA GYRASE SUBUNIT B)	5x6n	DUFFY BINDING PROTEIN (Plasmodium knowlesi)	5 / 12	ASN A 294 GLU A 292 ILE A 242 ASP A 26 GLN A 248	None	1.36A	4uroA-5x6nA: undetectable	4uroA-5x6nA: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_B_NOVB2000_1 (DNA GYRASE SUBUNIT B)	5x6n	DUFFY BINDING PROTEIN (Plasmodium knowlesi)	5 / 12	ASN A 294 GLU A 292 ILE A 242 ASP A 26 GLN A 248	None	1.31A	4uroB-5x6nA: undetectable	4uroB-5x6nA: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M10_A_NCAA603_0 (CYCLOHEXANONE MONOOXYGENASE FROM THERMOCRISPUM MUNICIPALE)	5x6n	DUFFY BINDING PROTEIN (Plasmodium knowlesi)	4 / 5	LEU A 71 ARG A 145 LEU A 49 TRP A 148	None	1.05A	5m10A-5x6nA: undetectable	5m10A-5x6nA: 19.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4B3A_A_TACA222_1","TETRACYCLINE REPRESSOR PROTEIN CLASS D","5x6n","DUFFY BINDING PROTEIN","Plasmodium knowlesi",5,"LEU A  87;ASN A  95;PHE A  98;ARG A 165;ILE A 175","None","1.35A","4b3aA-5x6nA:2.4","4b3aA-5x6nA:20.17"],["4K7A_A_MXDA1002_1","ANDROGEN RECEPTOR","5x6n","DUFFY BINDING PROTEIN","Plasmodium knowlesi",3,"GLU A 194;TRP A  27;LYS A 100","None;None;SO4 A 502 (-2.4A)","1.48A","4k7aA-5x6nA:undetectable","4k7aA-5x6nA:22.22"],["4URO_A_NOVA2000_1","DNA GYRASE SUBUNIT B","5x6n","DUFFY BINDING PROTEIN","Plasmodium knowlesi",5,"ASN A 294;GLU A 292;ILE A 242;ASP A  26;GLN A 248","None","1.36A","4uroA-5x6nA:undetectable","4uroA-5x6nA:19.76"],["4URO_B_NOVB2000_1","DNA GYRASE SUBUNIT B","5x6n","DUFFY BINDING PROTEIN","Plasmodium knowlesi",5,"ASN A 294;GLU A 292;ILE A 242;ASP A  26;GLN A 248","None","1.31A","4uroB-5x6nA:undetectable","4uroB-5x6nA:19.76"],["5M10_A_NCAA603_0","CYCLOHEXANONE MONOOXYGENASE FROM THERMOCRISPUM MUNICIPALE","5x6n","DUFFY BINDING PROTEIN","Plasmodium knowlesi",4,"LEU A  71;ARG A 145;LEU A  49;TRP A 148","None","1.05A","5m10A-5x6nA:undetectable","5m10A-5x6nA:19.96"]]