SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU C2112
ALA C2211
HIS C2218
LEU C2289
LEU C2299
 None
 1.05A 1bzfA-5x6oC:
undetectable		 1bzfA-5x6oC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		3 / 3 GLN C 555
HIS C 601
PRO C 557
 None
 0.77A 1d8cA-5x6oC:
2.0		 1d8cA-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 4 THR C 635
LEU C 647
LEU C 691
GLN C 694
 None
 1.18A 1fbmA-5x6oC:
undetectable		 1fbmA-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 548
LEU G 553
PHE G 645
VAL G 552
LEU G 461
 None
 1.01A 1rbpA-5x6oG:
undetectable		 1rbpA-5x6oG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 8 GLU C1354
ARG C2203
TRP C2199
GLU C1411
 None
 1.30A 1s3zA-5x6oC:
undetectable
1s3zB-5x6oC:
undetectable		 1s3zA-5x6oC:
undetectable
1s3zB-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 6 PRO C 556
PHE C 545
LEU C 544
ILE C 591
 None
 1.02A 1sbrA-5x6oC:
undetectable
1sbrB-5x6oC:
undetectable		 1sbrA-5x6oC:
17.10
1sbrB-5x6oC:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU C2299
ALA C2094
ILE C2116
ILE C2219
LEU C2220
 None
 1.14A 1tw4A-5x6oC:
undetectable		 1tw4A-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 6 ILE G 428
VAL G 424
VAL G 300
ILE G 282
 None
 0.78A 1uwhA-5x6oG:
2.3		 1uwhA-5x6oG:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 ALA C2271
ASN C2204
PHE C2189
LEU C2185
VAL C2239
 None
 1.13A 1xdkA-5x6oC:
undetectable		 1xdkA-5x6oC:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 215
ALA G 218
LEU G 359
ILE G 520
PHE G 298
 None
 1.35A 1y0xX-5x6oG:
undetectable		 1y0xX-5x6oG:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 8 PHE G 488
TYR G 367
PHE G 369
GLY G 490
 None
 1.08A 1ykiC-5x6oG:
undetectable
1ykiD-5x6oG:
undetectable		 1ykiC-5x6oG:
14.76
1ykiD-5x6oG:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 5 ASP G 497
GLY G 526
ALA G 534
ILE G 537
 None
 0.89A 2aofA-5x6oG:
undetectable		 2aofA-5x6oG:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 217
ALA G 218
ASP G 219
ILE G 508
PRO G 297
 None
 1.07A 2b7zA-5x6oG:
undetectable		 2b7zA-5x6oG:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 8 SER G 467
ASP C 494
LEU C 413
LEU C 260
 None
 0.89A 2bfpD-5x6oG:
undetectable		 2bfpD-5x6oG:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 10 ALA G 318
LEU G 275
SER G 381
LEU G 379
VAL G 378
 None
 1.02A 2bxgB-5x6oG:
undetectable		 2bxgB-5x6oG:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 GLN C1695
GLU C1724
LEU C1693
SER C1709
LEU C1710
 None
 0.90A 2c12C-5x6oC:
undetectable		 2c12C-5x6oC:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 11 GLN C1695
GLU C1724
LEU C1693
SER C1709
LEU C1710
 None
 0.88A 2c12F-5x6oC:
undetectable		 2c12F-5x6oC:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA602_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 5 HIS C2226
ILE C2230
LYS C2262
ASP C2224
 None
 1.47A 2f7fA-5x6oC:
0.0		 2f7fA-5x6oC:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 4 GLN G 353
GLU G 358
ILE G 354
PRO G 352
 None
 1.48A 2fcnA-5x6oG:
undetectable		 2fcnA-5x6oG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		3 / 3 ASN C1645
TYR C1628
SER C1635
 None
 0.90A 2gvcB-5x6oC:
undetectable		 2gvcB-5x6oC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		3 / 3 ASN C1645
TYR C1628
SER C1635
 None
 0.87A 2gvcE-5x6oC:
undetectable		 2gvcE-5x6oC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 8 PHE G 355
ILE G 525
GLY G 501
GLY G 502
 None
 0.73A 2qx4A-5x6oG:
undetectable
2qx4B-5x6oG:
undetectable		 2qx4A-5x6oG:
14.78
2qx4B-5x6oG:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 6 PHE G 298
ILE G 215
GLY G 502
GLY G 501
 None
 0.82A 2qx6A-5x6oG:
undetectable
2qx6B-5x6oG:
undetectable		 2qx6A-5x6oG:
14.78
2qx6B-5x6oG:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		4 / 6 PHE G 355
ILE G 525
GLY G 501
GLY G 502
 None
 0.75A 2qx6A-5x6oG:
undetectable
2qx6B-5x6oG:
undetectable		 2qx6A-5x6oG:
14.78
2qx6B-5x6oG:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 6 ARG C 897
ASP C 893
ILE C 891
GLN C 928
 None
 1.17A 2ya7C-5x6oC:
undetectable		 2ya7C-5x6oC:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 7 LEU C2264
ARG C2225
SER C2285
GLY C2217
 None
 1.08A 3hcrB-5x6oC:
undetectable		 3hcrB-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 926
GLU C 961
TRP C1169
SER C 930
 None
 1.38A 3i9jB-5x6oC:
undetectable		 3i9jB-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 8 GLY C1096
LEU C1098
LEU C1099
ILE C1120
 None
 0.90A 3nbqB-5x6oC:
undetectable		 3nbqB-5x6oC:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 8 GLY C1096
LEU C1098
LEU C1099
ILE C1120
 None
 0.88A 3nbqC-5x6oC:
undetectable		 3nbqC-5x6oC:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 615
PHE C 577
PHE C 595
VAL C 573
ASN C 626
 None
 1.47A 3nhxA-5x6oC:
undetectable		 3nhxA-5x6oC:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 TYR C1593
ASN C1596
GLU G 523
TYR C1573
 None
 1.11A 3rqwC-5x6oC:
4.0
3rqwD-5x6oC:
undetectable		 3rqwC-5x6oC:
undetectable
3rqwD-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 GLU G 523
TYR C1573
TYR C1593
ASN C1596
 None
 1.12A 3rqwF-5x6oG:
1.5
3rqwJ-5x6oG:
undetectable		 3rqwF-5x6oG:
undetectable
3rqwJ-5x6oG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 9 LEU C2112
ALA C2211
VAL C2239
GLY C2217
ILE C2219
 None
 1.14A 3spkA-5x6oC:
undetectable		 3spkA-5x6oC:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 712
LEU C 683
ILE C 687
ILE C 669
TYR C 900
 None
 1.22A 4a79A-5x6oC:
undetectable		 4a79A-5x6oC:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 712
LEU C 683
ILE C 687
ILE C 669
TYR C 900
 None
 1.16A 4a79B-5x6oC:
undetectable		 4a79B-5x6oC:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 11 LEU C 712
LEU C 683
ILE C 687
ILE C 669
TYR C 900
 None
 1.27A 4a7aA-5x6oC:
undetectable		 4a7aA-5x6oC:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 7 GLU C1568
GLU C1540
TYR C1665
HIS C1625
 None
 1.00A 4a97D-5x6oC:
3.9		 4a97D-5x6oC:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 ASP C1566
SER C1597
LEU C1627
ILE C1601
ARG C1567
 None
 1.30A 4kmuC-5x6oC:
undetectable		 4kmuC-5x6oC:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 ASP C1566
SER C1597
LEU C1627
ILE C1601
ARG C1567
 None
 1.13A 4kmuH-5x6oC:
undetectable		 4kmuH-5x6oC:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 10 LEU G 603
LEU G 546
VAL G 552
LEU G 460
LEU G 461
 None
 1.20A 4po0A-5x6oG:
3.5		 4po0A-5x6oG:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 6 CYH C 932
ILE C 931
GLN C 934
ILE C 910
 None
 1.18A 4w5tA-5x6oC:
undetectable		 4w5tA-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 9 GLN C1675
GLU C1585
ASN C1584
ILE C1580
ALA C1576
 None
 1.42A 5entC-5x6oC:
undetectable		 5entC-5x6oC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 6 LEU C1600
LEU C1627
LEU C1624
PHE C1605
 None
 0.76A 5gs4A-5x6oC:
undetectable		 5gs4A-5x6oC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 728
GLY C 696
ASP C 722
SER C 716
ILE C 710
 None
 1.40A 5igwA-5x6oC:
5.7		 5igwA-5x6oC:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 945
GLY C 909
ASN C 908
ALA C 834
ASN C 835
 None
 1.46A 5kc4A-5x6oC:
2.6		 5kc4A-5x6oC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 8 ASN C1700
ILE C1666
LEU C1696
PRO C1662
 None
 1.06A 5u4sB-5x6oC:
undetectable		 5u4sB-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 553
SER C 552
ARG C 504
 None
 1.00A 5u63A-5x6oC:
undetectable		 5u63A-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		3 / 3 SER G 579
LYS G 580
SER G 583
 None
 0.79A 6az3P-5x6oG:
undetectable		 6az3P-5x6oG:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1
(Saccharomyces
cerevisiae) 		4 / 6 TRP C1158
TYR C1297
GLN C1151
GLU C1140
 None
 1.48A 6djzC-5x6oC:
undetectable		 6djzC-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 9 MET G 640
LEU G 575
SER G 579
ILE G 631
SER G 636
 None
 1.49A 6dm2A-5x6oG:
1.3
6dm2D-5x6oG:
undetectable		 6dm2A-5x6oG:
17.65
6dm2D-5x6oG:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 9 ILE G 631
SER G 636
MET G 640
LEU G 575
SER G 579
 None
 1.47A 6dm2B-5x6oG:
undetectable
6dm2C-5x6oG:
1.3		 6dm2B-5x6oG:
17.65
6dm2C-5x6oG:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 418
VAL G 417
ILE G 465
HIS G 481
HIS G 486
 None
 1.46A 6j21A-5x6oG:
undetectable		 6j21A-5x6oG:
undetectable