SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 6 HIS A  38
ILE A  37
ALA A  96
VAL A 115
 None
 1.03A 1hk1A-5x6sA:
undetectable		 1hk1A-5x6sA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 10 GLY A  89
TYR A 132
ASN A  97
THR A  83
GLY A  90
 None
 1.36A 1kvlA-5x6sA:
undetectable		 1kvlA-5x6sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 11 LEU A   4
TYR A  22
GLY A  46
GLY A  44
TYR A  66
 None
 1.02A 1p91A-5x6sA:
undetectable		 1p91A-5x6sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 5 GLY A 265
ILE A 263
VAL A  34
SER A  51
 None
 1.17A 1rs7A-5x6sA:
undetectable		 1rs7A-5x6sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 6 GLY A 265
ILE A 263
VAL A  34
SER A  51
 None
 1.06A 1rs7B-5x6sA:
undetectable		 1rs7B-5x6sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 8 TYR A  53
ASP A 268
TRP A 271
TYR A 142
 None
 1.24A 2ha2A-5x6sA:
14.1		 2ha2A-5x6sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 8 TYR A  53
ASP A 268
TRP A 271
TYR A 142
 None
 1.24A 2ha2B-5x6sA:
14.4		 2ha2B-5x6sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 12 THR A  15
SER A  79
SER A 152
THR A 154
ALA A  82
 None
None
NAG  A 301 (-4.4A)
None
None
 1.03A 2x2iA-5x6sA:
undetectable		 2x2iA-5x6sA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 12 THR A  15
SER A  79
SER A 152
THR A 154
ALA A  82
 None
None
NAG  A 301 (-4.4A)
None
None
 0.99A 2x2iC-5x6sA:
undetectable		 2x2iC-5x6sA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 12 GLY A 144
TYR A 142
TYR A  39
TYR A 197
TRP A 217
 None
 1.43A 2zthA-5x6sA:
3.3		 2zthA-5x6sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 11 GLY A 265
ILE A 263
SER A  51
PRO A  52
THR A  55
 None
None
None
MES  A 303 ( 4.5A)
MES  A 303 (-4.6A)
 1.12A 3bjwB-5x6sA:
undetectable		 3bjwB-5x6sA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 11 GLY A 265
ILE A 263
SER A  51
PRO A  52
THR A  55
 None
None
None
MES  A 303 ( 4.5A)
MES  A 303 (-4.6A)
 1.13A 3bjwE-5x6sA:
undetectable		 3bjwE-5x6sA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 12 GLY A 265
ILE A 263
SER A  51
PRO A  52
THR A  55
 None
None
None
MES  A 303 ( 4.5A)
MES  A 303 (-4.6A)
 1.12A 3bjwF-5x6sA:
undetectable		 3bjwF-5x6sA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 11 GLY A 265
ILE A 263
SER A  51
PRO A  52
THR A  55
 None
None
None
MES  A 303 ( 4.5A)
MES  A 303 (-4.6A)
 1.16A 3bjwH-5x6sA:
undetectable		 3bjwH-5x6sA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 10 GLY A 107
ALA A 108
ASP A 109
VAL A  23
ILE A  63
 None
 0.96A 3ekyA-5x6sA:
undetectable		 3ekyA-5x6sA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 4 PRO A 262
THR A 260
GLY A  42
THR A  43
 None
 1.18A 3ib1A-5x6sA:
undetectable		 3ib1A-5x6sA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 6 TYR A 132
VAL A   7
VAL A  17
ILE A  65
 None
 1.11A 3pyyA-5x6sA:
undetectable		 3pyyA-5x6sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 9 PHE A  62
ALA A  54
PHE A 272
ALA A  36
THR A 116
 None
MES  A 303 ( 4.5A)
None
None
None
 1.47A 3t3sA-5x6sA:
undetectable		 3t3sA-5x6sA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 7 SER A 110
ASP A 109
THR A 102
SER A 111
 NA  A 305 ( 4.8A)
None
None
None
 1.00A 4ac9C-5x6sA:
3.3		 4ac9C-5x6sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 10 VAL A  64
TYR A  66
TYR A  22
GLY A  61
PHE A  62
 None
 1.46A 4mmcA-5x6sA:
undetectable		 4mmcA-5x6sA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 12 ILE A  95
GLY A  90
ALA A  82
THR A  85
VAL A 127
 None
 1.13A 4nkvC-5x6sA:
undetectable		 4nkvC-5x6sA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 8 ASN A  13
PRO A  14
PHE A  10
TYR A 132
 None
 1.41A 4v2zC-5x6sA:
undetectable		 4v2zC-5x6sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 8 ASN A  13
PRO A  14
PHE A  10
TYR A 132
 None
 1.33A 5amkA-5x6sA:
undetectable		 5amkA-5x6sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		3 / 3 THR A 260
SER A 118
ASP A 268
 None
 0.82A 5kvaB-5x6sA:
undetectable		 5kvaB-5x6sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		5 / 12 VAL A  34
GLY A  61
TYR A  53
PHE A 274
ALA A  28
 None
 1.17A 5n5dA-5x6sA:
undetectable		 5n5dA-5x6sA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 7 TYR A  53
ASP A 268
THR A 140
VAL A 261
 None
 1.13A 5ov9A-5x6sA:
13.9		 5ov9A-5x6sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5x6s ACETYLXYLAN ESTERASE
A
(Aspergillus
awamori) 		4 / 8 TYR A  53
ASP A 268
THR A 140
VAL A 261
 None
 1.12A 5ov9B-5x6sA:
14.1		 5ov9B-5x6sA:
19.49