SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5x6v RAGULATOR COMPLEX
PROTEIN LAMTOR2
(Homo
sapiens) 		4 / 8 LEU B  73
LEU B 104
LYS B 107
ALA B 108
 None
 0.95A 2wekA-5x6vB:
undetectable		 2wekA-5x6vB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5x6v RAS-RELATED
GTP-BINDING PROTEIN
C
(Mus
musculus) 		5 / 9 PHE G 366
LEU G 334
VAL G 330
LEU G 242
ILE G 362
 None
 1.06A 3tbgD-5x6vG:
undetectable		 3tbgD-5x6vG:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x6v RAS-RELATED
GTP-BINDING PROTEIN
C
(Mus
musculus) 		4 / 6 LEU G 260
TYR G 268
LEU G 246
GLU G 243
 None
ACT  G 401 (-4.5A)
None
None
 1.03A 4f3tA-5x6vG:
undetectable		 4f3tA-5x6vG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 5x6v RAGULATOR COMPLEX
PROTEIN LAMTOR2
(Homo
sapiens) 		4 / 5 LEU B  23
TYR B  94
ALA B  49
ILE B  83
 None
 1.10A 4y03B-5x6vB:
undetectable		 4y03B-5x6vB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5x6v RAGULATOR COMPLEX
PROTEIN LAMTOR2
RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens;
Mus
musculus) 		5 / 11 GLY G 349
ALA B  46
SER B  30
LEU B  31
ASN B  26
 None
 0.98A 5x6yA-5x6vG:
undetectable		 5x6yA-5x6vG:
undetectable