SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  75
ALA A 102
VAL A  71
 None
None
SAM  A 301 (-3.6A)
 0.88A 1c4dC-5x7fA:
undetectable
1c4dD-5x7fA:
undetectable		 1c4dC-5x7fA:
25.58
1c4dD-5x7fA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  65
GLY A  66
ASP A  90
ILE A  91
ALA A 139
 None
SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.5A)
 0.50A 1cetA-5x7fA:
4.3		 1cetA-5x7fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 209
GLY A 208
VAL A 203
TRP A  14
 None
 1.01A 1tkqB-5x7fA:
undetectable		 1tkqB-5x7fA:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
SER A  72
ALA A 120
ALA A 139
TYR A 147
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
None
 0.53A 2avdA-5x7fA:
27.4		 2avdA-5x7fA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A 120
ASP A 138
ALA A 139
TYR A 147
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.5A)
None
 0.46A 2avdB-5x7fA:
27.7		 2avdB-5x7fA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  66
SER A  72
ILE A  89
ASP A 138
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
None
SAM  A 301 (-3.6A)
 0.35A 3a7eA-5x7fA:
20.5		 3a7eA-5x7fA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  66
SER A  72
ILE A  91
ASP A 138
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.6A)
 0.46A 3a7eA-5x7fA:
20.5		 3a7eA-5x7fA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
GLU A  64
GLY A  66
ILE A  91
GLN A 121
 SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.2A)
 0.82A 3bwyA-5x7fA:
20.9		 3bwyA-5x7fA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 11 GLU A  64
GLY A  66
GLY A  68
ILE A  89
ALA A 120
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.5A)
 0.44A 3dxyA-5x7fA:
13.7		 3dxyA-5x7fA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 11 GLU A  64
GLY A  66
GLY A  68
ILE A  89
ASP A 140
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 ( 3.8A)
 0.91A 3dxyA-5x7fA:
13.7		 3dxyA-5x7fA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  64
GLY A  66
GLY A  68
ILE A  91
ALA A 120
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.5A)
 0.64A 3gryA-5x7fA:
13.1		 3gryA-5x7fA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  70
ARG A  33
ASP A 138
VAL A 209
GLY A  47
 SAM  A 301 ( 4.5A)
None
SAM  A 301 (-3.6A)
None
None
 1.25A 3k13A-5x7fA:
undetectable		 3k13A-5x7fA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  62
LEU A  76
ILE A 161
GLY A 159
SER A  57
 None
 1.10A 3kk6A-5x7fA:
undetectable		 3kk6A-5x7fA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  62
LEU A  76
ILE A 161
GLY A 159
SER A  57
 None
 1.04A 3kk6B-5x7fA:
undetectable		 3kk6B-5x7fA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
ALA A  41
GLY A  40
ALA A  99
LEU A  50
 SAM  A 301 (-3.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.8A)
None
None
 1.13A 3qxyA-5x7fA:
undetectable		 3qxyA-5x7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
ALA A  41
GLY A  40
ALA A 102
LEU A  50
 SAM  A 301 (-3.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.8A)
None
None
 1.02A 3qxyA-5x7fA:
undetectable		 3qxyA-5x7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  42
ALA A  41
GLY A  40
ALA A  99
LEU A  50
 SAM  A 301 (-3.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.8A)
None
None
 1.13A 3rc0A-5x7fA:
undetectable		 3rc0A-5x7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
ALA A  41
GLY A  40
ALA A  99
LEU A  50
 SAM  A 301 (-3.5A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.8A)
None
None
 1.12A 3rc0B-5x7fA:
undetectable		 3rc0B-5x7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
GLY A  68
ASP A  90
ILE A  91
ALA A 139
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.5A)
 0.64A 4iv8A-5x7fA:
13.1		 4iv8A-5x7fA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
GLY A  68
ASP A  90
ILE A  91
ALA A 139
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.5A)
 0.61A 4iv8B-5x7fA:
13.3		 4iv8B-5x7fA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 120
ILE A 137
GLY A 151
THR A  87
ILE A  89
 SAM  A 301 (-3.5A)
None
None
None
None
 0.89A 4njtC-5x7fA:
undetectable		 4njtC-5x7fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 124
GLY A 151
LEU A 155
VAL A  62
ILE A 192
 None
 1.40A 4okbA-5x7fA:
undetectable		 4okbA-5x7fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  39
GLY A  66
ALA A 120
ALA A 139
TYR A 147
 SAM  A 301 ( 4.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
None
 0.98A 4pclA-5x7fA:
26.7		 4pclA-5x7fA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  64
GLY A  66
ALA A 120
ALA A 139
TYR A 147
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
None
 0.39A 4pclB-5x7fA:
26.7		 4pclB-5x7fA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
GLY A  68
GLY A  70
ALA A 120
ALA A 139
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 ( 4.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
 0.60A 4uciA-5x7fA:
7.2		 4uciA-5x7fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
GLY A  68
GLY A  70
ALA A 120
ALA A 139
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 ( 4.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
 0.60A 4uciB-5x7fA:
7.5		 4uciB-5x7fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
GLY A  68
GLY A  70
ALA A 120
ALA A 139
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 ( 4.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
 0.61A 4uckA-5x7fA:
7.7		 4uckA-5x7fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
GLU A  64
GLY A  66
ILE A  89
ILE A  91
 SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
 0.41A 4xucA-5x7fA:
20.7		 4xucA-5x7fA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
GLU A  64
GLY A  66
ILE A  89
ILE A  91
 SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
 0.43A 4xudA-5x7fA:
20.5		 4xudA-5x7fA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
GLY A  66
SER A  72
ILE A  91
GLN A 121
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.2A)
 0.91A 4xueB-5x7fA:
20.7		 4xueB-5x7fA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  66
SER A  72
ALA A 120
ASP A 138
ALA A 139
TYR A 147
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.5A)
None
 0.45A 4ymgB-5x7fA:
22.1		 4ymgB-5x7fA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  39
GLY A  66
GLY A  68
HIS A  95
ASP A 138
 SAM  A 301 ( 4.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.6A)
 0.74A 5c0oE-5x7fA:
19.5		 5c0oE-5x7fA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
GLY A  68
GLY A  73
HIS A  95
ASP A 138
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.8A)
SAM  A 301 (-3.6A)
 0.96A 5c0oE-5x7fA:
19.5		 5c0oE-5x7fA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  18
LEU A  49
GLY A 208
ALA A 201
VAL A 162
 None
 0.99A 5kbwB-5x7fA:
undetectable		 5kbwB-5x7fA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		7 / 12 GLU A  64
GLY A  66
ILE A  91
ALA A 120
ASP A 138
ALA A 139
TYR A 147
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.5A)
None
 0.50A 5kvaA-5x7fA:
24.9		 5kvaA-5x7fA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		6 / 12 GLU A  64
GLY A  66
ILE A  91
ASP A 138
ALA A 139
ASP A 140
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 3.8A)
 1.18A 5kvaA-5x7fA:
24.9		 5kvaA-5x7fA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		7 / 12 GLU A  64
GLY A  66
ILE A  91
ALA A 120
ASP A 138
ALA A 139
TYR A 147
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.5A)
None
 0.54A 5kvaB-5x7fA:
23.1		 5kvaB-5x7fA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		6 / 12 GLU A  64
GLY A  66
ILE A  91
ASP A 138
ALA A 139
ASP A 140
 SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 3.8A)
 1.23A 5kvaB-5x7fA:
23.1		 5kvaB-5x7fA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
GLU A  64
GLY A  66
ILE A  91
GLN A 121
 SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.2A)
 0.87A 5lsaA-5x7fA:
20.7		 5lsaA-5x7fA:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		9 / 12 ALA A  41
VAL A  42
GLU A  64
GLY A  66
GLU A  92
ALA A 120
PHE A 136
ALA A 139
TYR A 147
 SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.5A)
None
 0.43A 5n5dA-5x7fA:
26.7		 5n5dA-5x7fA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		6 / 12 ALA A  69
GLU A  64
GLY A  66
ALA A 120
ALA A 139
TYR A 147
 None
SAM  A 301 ( 4.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
None
 1.47A 5n5dA-5x7fA:
26.7		 5n5dA-5x7fA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  64
GLU A  92
ARG A 119
ALA A 120
TYR A 147
 SAM  A 301 ( 4.7A)
None
SAM  A 301 (-4.6A)
SAM  A 301 (-3.5A)
None
 0.86A 5n5dA-5x7fA:
26.7		 5n5dA-5x7fA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		8 / 12 ALA A  41
VAL A  42
GLU A  64
ILE A  89
ALA A 120
PHE A 136
ALA A 139
TYR A 147
 SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
None
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.5A)
None
 0.43A 5n5dB-5x7fA:
26.8		 5n5dB-5x7fA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		8 / 12 ALA A  41
VAL A  42
GLU A  64
ILE A  89
GLU A  92
ALA A 120
PHE A 136
ALA A 139
 SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.7A)
None
None
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.5A)
 0.64A 5n5dB-5x7fA:
26.8		 5n5dB-5x7fA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  66
SER A  72
ARG A 119
ASP A 138
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.8A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.6A)
 0.79A 5n5dB-5x7fA:
26.8		 5n5dB-5x7fA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		12 / 12 GLY A  40
VAL A  42
GLY A  66
GLY A  68
VAL A  71
ILE A  91
GLU A  92
ALA A 120
GLN A 121
ALA A 139
ASP A 140
TYR A 147
 SAM  A 301 (-3.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.9A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 3.8A)
None
 0.02A 5x7fA-5x7fA:
41.7		 5x7fA-5x7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7F_A_SAMA301_1
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C
(Mycobacterium
tuberculosis) 		4 / 4 SER A  72
ASP A  90
HIS A  95
ASP A 138
 SAM  A 301 (-2.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.6A)
 0.00A 5x7fA-5x7fA:
41.7		 5x7fA-5x7fA:
100.00