SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 12 GLU A 333
VAL A 351
PHE A 353
LEU A 374
THR A 373
 None
 1.17A 1oq5A-5x7kA:
undetectable		 1oq5A-5x7kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 9 GLU A 424
ASN A 425
ILE A 476
ALA A 441
VAL A 446
 None
 1.40A 2drdA-5x7kA:
undetectable		 2drdA-5x7kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 9 LEU A 522
PRO A 494
LEU A 506
LEU A 411
ALA A 481
 None
 1.27A 2vcvH-5x7kA:
undetectable		 2vcvH-5x7kA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 11 GLN A 413
THR A 373
VAL A 521
LEU A 522
ILE A 363
 None
 1.48A 3elzB-5x7kA:
undetectable		 3elzB-5x7kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 12 GLN A 413
THR A 373
VAL A 521
LEU A 522
ILE A 363
 None
 1.32A 3elzC-5x7kA:
undetectable		 3elzC-5x7kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5x7k LIPASE B
(Serratia
marcescens) 		4 / 7 LEU A 443
LEU A 482
ILE A 510
MET A 532
 None
 0.99A 3u5jA-5x7kA:
undetectable		 3u5jA-5x7kA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 12 LEU A 391
LEU A 537
ILE A 355
VAL A 351
LEU A 348
 None
 1.22A 4y0pA-5x7kA:
undetectable		 4y0pA-5x7kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 5x7k LIPASE B
(Serratia
marcescens) 		5 / 12 ILE A 450
PHE A 453
ILE A 426
ALA A 441
LEU A 468
 None
 1.01A 5jkvA-5x7kA:
undetectable		 5jkvA-5x7kA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 5x7k LIPASE B
(Serratia
marcescens) 		4 / 7 VAL A 351
PHE A 353
LEU A 374
THR A 373
 None
 0.92A 5m78A-5x7kA:
undetectable		 5m78A-5x7kA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5x7k LIPASE B
(Serratia
marcescens) 		4 / 5 ALA A 481
TYR A 410
GLN A 474
ILE A 415
 None
 1.15A 6g9bA-5x7kA:
undetectable
6g9bB-5x7kA:
undetectable		 6g9bA-5x7kA:
14.66
6g9bB-5x7kA:
15.83