SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 5x7l TSRD
(Streptomyces
laurentii) 		5 / 12 HIS A 117
PHE A  13
HIS A  35
ASP A 119
ASP A 105
 IPA  A 202 (-3.5A)
None
None
IPA  A 202 ( 4.8A)
IPA  A 202 (-2.9A)
 1.32A 1a4lB-5x7lA:
undetectable		 1a4lB-5x7lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5x7l TSRD
(Streptomyces
laurentii) 		5 / 12 HIS A 117
PHE A  13
HIS A  35
ASP A 119
ASP A 105
 IPA  A 202 (-3.5A)
None
None
IPA  A 202 ( 4.8A)
IPA  A 202 (-2.9A)
 1.29A 1a4lC-5x7lA:
undetectable		 1a4lC-5x7lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5x7l TSRD
(Streptomyces
laurentii) 		5 / 12 HIS A 117
PHE A  13
HIS A  35
ASP A 119
ASP A 105
 IPA  A 202 (-3.5A)
None
None
IPA  A 202 ( 4.8A)
IPA  A 202 (-2.9A)
 1.26A 1a4lD-5x7lA:
undetectable		 1a4lD-5x7lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5x7l TSRD
(Streptomyces
laurentii) 		5 / 12 ALA A  50
LEU A  61
PHE A  81
LEU A 103
PHE A  13
 None
None
IPA  A 201 ( 3.6A)
IPA  A 201 ( 4.8A)
None
 1.14A 1dtlA-5x7lA:
undetectable		 1dtlA-5x7lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5x7l TSRD
(Streptomyces
laurentii) 		3 / 3 HIS A  12
HIS A  24
HIS A  27
 None
 0.73A 1w2zA-5x7lA:
4.3		 1w2zA-5x7lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 5x7l TSRD
(Streptomyces
laurentii) 		4 / 5 LEU A  63
LEU A  14
LEU A   9
MET A  79
 IPA  A 201 ( 4.5A)
None
None
None
 1.05A 2oaxF-5x7lA:
undetectable		 2oaxF-5x7lA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5x7l TSRD
(Streptomyces
laurentii) 		4 / 4 TYR A  33
LEU A 113
LEU A  29
HIS A 117
 None
None
None
IPA  A 202 (-3.5A)
 1.48A 2x7hB-5x7lA:
undetectable		 2x7hB-5x7lA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5x7l TSRD
(Streptomyces
laurentii) 		4 / 8 MET A  47
LEU A   9
MET A  10
HIS A 117
 IPA  A 202 (-4.3A)
None
None
IPA  A 202 (-3.5A)
 1.23A 5dxeA-5x7lA:
undetectable		 5dxeA-5x7lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5x7l TSRD
(Streptomyces
laurentii) 		5 / 12 GLY A  46
TYR A  33
ASP A 119
HIS A 117
GLU A 120
 None
None
IPA  A 202 ( 4.8A)
IPA  A 202 (-3.5A)
None
 1.40A 5igwA-5x7lA:
2.4		 5igwA-5x7lA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5x7l TSRD
(Streptomyces
laurentii) 		4 / 6 GLN A 129
MET A  79
VAL A 101
LEU A 103
 IPA  A 203 (-3.7A)
None
None
IPA  A 201 ( 4.8A)
 1.02A 5xdhA-5x7lA:
undetectable
5xdhC-5x7lA:
undetectable		 5xdhA-5x7lA:
22.83
5xdhC-5x7lA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5x7l TSRD
(Streptomyces
laurentii) 		4 / 8 MET A  47
LEU A   9
MET A  10
HIS A 117
 IPA  A 202 (-4.3A)
None
None
IPA  A 202 (-3.5A)
 1.22A 6cbzA-5x7lA:
undetectable		 6cbzA-5x7lA:
23.81