SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 6 ARG A  21
TYR A 313
ASP A 340
ASN A 341
 None
 1.17A 1rjdC-5x7nA:
undetectable		 1rjdC-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 10 ILE A  82
VAL A  48
TYR A 406
GLY A 402
TYR A  72
 None
 1.48A 1s1uA-5x7nA:
undetectable		 1s1uA-5x7nA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 4 THR A  43
GLY A 337
ASP A 378
ALA A 333
 None
 1.22A 1sg9A-5x7nA:
undetectable		 1sg9A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 218
SER A 219
ARG A 302
ARG A 343
TYR A 347
 None
PLP  A 504 ( 4.8A)
LYS  A 505 ( 3.8A)
LYS  A 505 (-4.3A)
LYS  A 505 (-4.0A)
 1.17A 1tufA-5x7nA:
46.7
1tufB-5x7nA:
46.7		 1tufA-5x7nA:
11.50
1tufB-5x7nA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 9 HIS A 216
GLY A 218
SER A 219
ARG A 302
TYR A 347
 PLP  A 504 (-3.5A)
None
PLP  A 504 ( 4.8A)
LYS  A 505 ( 3.8A)
LYS  A 505 (-4.0A)
 1.12A 1tufA-5x7nA:
46.7
1tufB-5x7nA:
46.7		 1tufA-5x7nA:
11.50
1tufB-5x7nA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 MET A  60
LEU A  91
ASP A  94
LEU A 162
HIS A 117
 None
None
None
None
PLP  A 504 (-3.9A)
 1.46A 1uobA-5x7nA:
undetectable		 1uobA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 5 LEU A 145
PHE A 188
VAL A 161
ALA A 202
 None
 1.10A 2cizA-5x7nA:
undetectable		 2cizA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 10 THR A  43
VAL A 315
GLY A 393
VAL A 356
VAL A 355
 None
 1.30A 2cp4A-5x7nA:
undetectable		 2cp4A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 PRO A  16
THR A 401
VAL A 310
LEU A  37
ILE A 312
 None
 1.45A 2fj1A-5x7nA:
undetectable		 2fj1A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 MET A 285
LEU A 252
LEU A 190
PRO A 167
VAL A 165
 None
 1.22A 2hrcA-5x7nA:
undetectable		 2hrcA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 MET A 285
LEU A 252
LEU A 190
PRO A 167
VAL A 165
 None
 1.16A 2hrcB-5x7nA:
3.4		 2hrcB-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 11 MET A 285
LEU A 252
LEU A 190
PRO A 167
VAL A 165
 None
 1.33A 2po5B-5x7nA:
3.3		 2po5B-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A  44
GLY A 336
TYR A 313
 None
 0.62A 2vouA-5x7nA:
undetectable		 2vouA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A  44
GLY A 336
TYR A 313
 None
 0.60A 2vouB-5x7nA:
undetectable		 2vouB-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A  44
GLY A 336
TYR A 313
 None
 0.61A 2vouC-5x7nA:
undetectable		 2vouC-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 6 ARG A 343
ARG A 302
ILE A 260
TYR A 351
 LYS  A 505 (-4.3A)
LYS  A 505 ( 3.8A)
None
None
 1.15A 2yfbB-5x7nA:
undetectable		 2yfbB-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 5 ASP A 389
ILE A 385
ILE A 390
GLY A 362
 None
 0.85A 3bufA-5x7nA:
undetectable		 3bufA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 11 LEU A  93
LEU A 105
ALA A 104
ASN A  99
VAL A 134
 None
 1.02A 3e22D-5x7nA:
undetectable		 3e22D-5x7nA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		3 / 3 GLU A  39
GLY A  42
THR A  43
 None
 0.50A 3iazA-5x7nA:
undetectable		 3iazA-5x7nA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 6 SER A 410
PHE A 415
ASP A 378
PRO A  44
 None
 1.26A 3jqaB-5x7nA:
2.1		 3jqaB-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 10 LYS A  75
HIS A 216
GLY A 218
ARG A 302
TYR A 404
 PLP  A 504 ( 1.2A)
PLP  A 504 (-3.5A)
None
LYS  A 505 ( 3.8A)
LYS  A 505 ( 3.7A)
 0.94A 3n2oC-5x7nA:
27.4
3n2oD-5x7nA:
27.5		 3n2oC-5x7nA:
8.24
3n2oD-5x7nA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		6 / 12 ILE A  82
TRP A  85
ALA A 305
THR A 309
VAL A 420
LEU A 430
 None
 1.41A 3s79A-5x7nA:
undetectable		 3s79A-5x7nA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 9 ILE A  82
TRP A  85
ALA A 305
THR A 309
VAL A 420
 None
 1.07A 3s7sA-5x7nA:
undetectable		 3s7sA-5x7nA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  91
ILE A  82
GLY A 301
CYH A  57
ALA A  73
 None
None
PLP  A 504 (-3.4A)
None
PLP  A 504 ( 3.8A)
 1.22A 3uj7A-5x7nA:
undetectable		 3uj7A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 10 ILE A  82
TRP A  85
ALA A 305
THR A 309
VAL A 420
 None
 1.08A 4kq8A-5x7nA:
undetectable		 4kq8A-5x7nA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 4 ALA A 195
ALA A 198
ALA A 199
ALA A 202
 None
 0.11A 4oadA-5x7nA:
undetectable		 4oadA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 4 ALA A 195
ALA A 198
ALA A 199
ALA A 202
 None
 0.09A 4oaeA-5x7nA:
undetectable		 4oaeA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 139
ALA A 198
ILE A 241
VAL A 161
ILE A 163
 None
 0.99A 4q1yB-5x7nA:
undetectable		 4q1yB-5x7nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 163
GLN A 240
TYR A 238
LEU A 213
LEU A 190
 None
 1.26A 4qztC-5x7nA:
undetectable		 4qztC-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 8 ARG A  17
VAL A  29
ASP A  51
ASP A  49
 None
 1.05A 4xqgA-5x7nA:
undetectable		 4xqgA-5x7nA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		4 / 8 ARG A  17
VAL A  29
ASP A  51
ASP A  49
 None
 1.06A 4xqgB-5x7nA:
undetectable		 4xqgB-5x7nA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  52
THR A  79
THR A  81
TYR A  72
CYH A  57
 None
 1.30A 5dsgA-5x7nA:
undetectable		 5dsgA-5x7nA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		6 / 12 ILE A  82
TRP A  85
ALA A 305
THR A 309
VAL A 420
LEU A 430
 None
 1.43A 5jkvA-5x7nA:
undetectable		 5jkvA-5x7nA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5x7n DIAMINOPIMELATE
DECARBOXYLASE
(Corynebacterium
glutamicum) 		3 / 3 THR A 391
THR A 318
ARG A 330
 None
 0.90A 5wm2A-5x7nA:
2.1		 5wm2A-5x7nA:
undetectable