SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 4 THR A 951
PRO A 908
THR A 952
PRO A 984
None
1.35A 1a7yA-5x7sA:
undetectable
1a7yC-5x7sA:
undetectable
1a7yA-5x7sA:
1.72
1a7yC-5x7sA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.48A 1c9sA-5x7sA:
undetectable
1c9sK-5x7sA:
undetectable
1c9sA-5x7sA:
4.73
1c9sK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.49A 1c9sA-5x7sA:
undetectable
1c9sB-5x7sA:
2.1
1c9sA-5x7sA:
4.73
1c9sB-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1c9sC-5x7sA:
undetectable
1c9sD-5x7sA:
undetectable
1c9sC-5x7sA:
4.73
1c9sD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1c9sD-5x7sA:
undetectable
1c9sE-5x7sA:
undetectable
1c9sD-5x7sA:
4.73
1c9sE-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1c9sE-5x7sA:
undetectable
1c9sF-5x7sA:
1.6
1c9sE-5x7sA:
4.73
1c9sF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1c9sF-5x7sA:
1.6
1c9sG-5x7sA:
undetectable
1c9sF-5x7sA:
4.73
1c9sG-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1c9sH-5x7sA:
undetectable
1c9sI-5x7sA:
undetectable
1c9sH-5x7sA:
4.73
1c9sI-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1c9sJ-5x7sA:
undetectable
1c9sK-5x7sA:
undetectable
1c9sJ-5x7sA:
4.73
1c9sK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.48A 1c9sL-5x7sA:
undetectable
1c9sM-5x7sA:
undetectable
1c9sL-5x7sA:
4.73
1c9sM-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 1c9sM-5x7sA:
undetectable
1c9sN-5x7sA:
undetectable
1c9sM-5x7sA:
4.73
1c9sN-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 1c9sO-5x7sA:
undetectable
1c9sP-5x7sA:
undetectable
1c9sO-5x7sA:
4.73
1c9sP-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.50A 1c9sS-5x7sA:
2.3
1c9sT-5x7sA:
2.3
1c9sS-5x7sA:
4.73
1c9sT-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 4 GLU A1082
MET A1085
LEU A1042
SER A1043
None
1.11A 1ee2B-5x7sA:
undetectable
1ee2B-5x7sA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.47A 1gtfA-5x7sA:
undetectable
1gtfK-5x7sA:
undetectable
1gtfA-5x7sA:
4.73
1gtfK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1gtfA-5x7sA:
undetectable
1gtfB-5x7sA:
undetectable
1gtfA-5x7sA:
4.73
1gtfB-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1gtfB-5x7sA:
undetectable
1gtfC-5x7sA:
undetectable
1gtfB-5x7sA:
4.73
1gtfC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1gtfE-5x7sA:
undetectable
1gtfF-5x7sA:
undetectable
1gtfE-5x7sA:
4.73
1gtfF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1gtfF-5x7sA:
undetectable
1gtfG-5x7sA:
undetectable
1gtfF-5x7sA:
4.73
1gtfG-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 1gtfI-5x7sA:
1.6
1gtfJ-5x7sA:
1.7
1gtfI-5x7sA:
4.73
1gtfJ-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 1gtnG-5x7sA:
undetectable
1gtnH-5x7sA:
2.1
1gtnG-5x7sA:
4.73
1gtnH-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.50A 1gtnS-5x7sA:
undetectable
1gtnT-5x7sA:
undetectable
1gtnS-5x7sA:
4.73
1gtnT-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 8 GLU A 319
GLY A 318
GLU A 324
ILE A 359
ASP A 390
MG  A1604 ( 4.3A)
None
None
None
None
1.38A 1jg4A-5x7sA:
undetectable
1jg4A-5x7sA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 730
GLY A 767
SER A 768
GLU A 748
GLY A 765
EDO  A1802 (-4.8A)
None
None
None
None
1.29A 1l5kA-5x7sA:
undetectable
1l5kA-5x7sA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 730
GLY A 767
SER A 768
GLU A 748
GLY A 765
EDO  A1802 (-4.8A)
None
None
None
None
1.27A 1l5lA-5x7sA:
undetectable
1l5lA-5x7sA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 ARG A 468
TYR A 456
SER A 746
TYR A 732
None
1.24A 1nx9A-5x7sA:
3.5
1nx9A-5x7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 ARG A 468
TYR A 456
SER A 746
TYR A 732
None
1.25A 1nx9B-5x7sA:
undetectable
1nx9B-5x7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 ARG A 468
TYR A 456
SER A 746
TYR A 732
None
1.26A 1nx9C-5x7sA:
3.4
1nx9C-5x7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 ARG A 468
TYR A 456
SER A 746
TYR A 732
None
1.24A 1nx9D-5x7sA:
4.4
1nx9D-5x7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 PHE A 729
LEU A 751
VAL A 764
VAL A 718
ALA A 831
EDO  A1802 (-3.7A)
None
None
None
None
1.09A 1q23H-5x7sA:
undetectable
1q23I-5x7sA:
undetectable
1q23H-5x7sA:
8.99
1q23I-5x7sA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 7 TYR A 964
THR A 687
THR A 685
VAL A 932
None
1.01A 1tv8B-5x7sA:
undetectable
1tv8B-5x7sA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 1utdA-5x7sA:
2.3
1utdB-5x7sA:
2.2
1utdA-5x7sA:
4.73
1utdB-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 1utdC-5x7sA:
undetectable
1utdD-5x7sA:
undetectable
1utdC-5x7sA:
4.73
1utdD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 1utdG-5x7sA:
undetectable
1utdH-5x7sA:
undetectable
1utdG-5x7sA:
4.73
1utdH-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.50A 1utdA-5x7sA:
2.3
1utdK-5x7sA:
1.5
1utdA-5x7sA:
4.73
1utdK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 PHE A1135
VAL A1275
ILE A1190
GLY A1259
LEU A1130
None
1.07A 1z11C-5x7sA:
undetectable
1z11C-5x7sA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 PHE A1135
VAL A1275
ILE A1190
GLY A1259
LEU A1130
None
1.11A 1z11D-5x7sA:
undetectable
1z11D-5x7sA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 4 THR A 472
THR A 448
ASP A 432
ASP A 435
None
1.44A 2f8lA-5x7sA:
2.7
2f8lA-5x7sA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 6 SER A  50
ASP A  68
SER A  47
VAL A  45
None
1.16A 2hdnI-5x7sA:
undetectable
2hdnJ-5x7sA:
undetectable
2hdnL-5x7sA:
undetectable
2hdnI-5x7sA:
3.65
2hdnJ-5x7sA:
13.64
2hdnL-5x7sA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 6 SER A  47
VAL A  45
SER A  50
ASP A  68
None
1.17A 2hdnJ-5x7sA:
undetectable
2hdnK-5x7sA:
undetectable
2hdnL-5x7sA:
undetectable
2hdnJ-5x7sA:
13.64
2hdnK-5x7sA:
3.65
2hdnL-5x7sA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 GLN A 989
ALA A1114
PRO A 987
LEU A1123
SER A1125
None
1.11A 2nv4B-5x7sA:
undetectable
2nv4B-5x7sA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 LEU A 646
PRO A 544
SER A 545
GLY A 493
None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
1.11A 2qd5A-5x7sA:
undetectable
2qd5A-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 LEU A 646
PRO A 544
SER A 545
GLY A 493
None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
1.05A 2qd5B-5x7sA:
undetectable
2qd5B-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 5 GLU A 257
PRO A 255
ILE A 258
GLY A 253
None
1.15A 2qeuA-5x7sA:
undetectable
2qeuC-5x7sA:
undetectable
2qeuA-5x7sA:
8.59
2qeuC-5x7sA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 PRO A 546
ASN A1175
ARG A1174
None
0.94A 2qeuB-5x7sA:
2.6
2qeuB-5x7sA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.32A 2qmjA-5x7sA:
19.3
2qmjA-5x7sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 LEU A  53
GLU A  66
GLY A  83
LEU A  51
SER A  50
None
0.97A 2qmmA-5x7sA:
undetectable
2qmmB-5x7sA:
undetectable
2qmmA-5x7sA:
9.23
2qmmB-5x7sA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 6 ASP A 719
PHE A 721
ASP A 819
TYR A 821
None
1.20A 2todA-5x7sA:
1.7
2todB-5x7sA:
2.4
2todA-5x7sA:
15.90
2todB-5x7sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 5 ASP A 819
TYR A 821
ASP A 719
PHE A 721
None
1.16A 2todA-5x7sA:
1.6
2todB-5x7sA:
2.2
2todA-5x7sA:
15.90
2todB-5x7sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 5 ASP A 719
PHE A 721
ASP A 819
TYR A 821
None
1.18A 2todC-5x7sA:
2.2
2todD-5x7sA:
2.4
2todC-5x7sA:
15.90
2todD-5x7sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 5 ASP A 819
TYR A 821
ASP A 719
PHE A 721
None
1.17A 2todC-5x7sA:
2.2
2todD-5x7sA:
2.4
2todC-5x7sA:
15.90
2todD-5x7sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 7 LEU A1270
ALA A1221
GLY A1259
PHE A1180
None
0.86A 2wq5A-5x7sA:
undetectable
2wq5A-5x7sA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 7 VAL A 564
GLY A 531
PRO A 544
ARG A 563
None
None
EDO  A1804 (-4.8A)
None
0.96A 3bjwC-5x7sA:
undetectable
3bjwC-5x7sA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 VAL A 564
GLY A 531
PRO A 544
ARG A 563
None
None
EDO  A1804 (-4.8A)
None
0.93A 3bjwA-5x7sA:
undetectable
3bjwA-5x7sA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 LEU A 646
PRO A 544
SER A 545
GLY A 493
None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
1.08A 3hcrA-5x7sA:
undetectable
3hcrA-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 7 LEU A 646
PRO A 544
SER A 545
GLY A 493
None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
1.07A 3hcrB-5x7sA:
undetectable
3hcrB-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 GLU A 292
ASP A 334
ASP A 287
None
0.77A 3jb2A-5x7sA:
undetectable
3jb2A-5x7sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 TYR A1203
VAL A1251
VAL A1193
ASN A1199
GLY A1254
None
1.31A 3km6B-5x7sA:
undetectable
3km6B-5x7sA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 TYR A1203
VAL A1251
VAL A1193
ASN A1199
GLY A1254
None
1.35A 3kmoA-5x7sA:
undetectable
3kmoA-5x7sA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.43A 3l4wA-5x7sA:
11.4
3l4wA-5x7sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.44A 3phaA-5x7sA:
21.7
3phaA-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 432
ASP A 529
ILE A 492
ASP A 491
ASP A 429
None
1.41A 3phaA-5x7sA:
21.7
3phaA-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.43A 3phaB-5x7sA:
19.1
3phaB-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 432
ASP A 529
ILE A 492
ASP A 491
ASP A 429
None
1.36A 3phaB-5x7sA:
19.1
3phaB-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 432
ILE A 492
ASP A 491
ASP A 429
HIS A 565
None
1.49A 3phaB-5x7sA:
19.1
3phaB-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.41A 3phaC-5x7sA:
21.6
3phaC-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.36A 3phaD-5x7sA:
21.5
3phaD-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 432
ASP A 529
ILE A 492
ASP A 491
ASP A 429
None
1.28A 3phaD-5x7sA:
21.5
3phaD-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 432
ILE A 492
ASP A 491
ASP A 429
HIS A 565
None
1.45A 3phaD-5x7sA:
21.5
3phaD-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.47A 3pocA-5x7sA:
21.4
3pocA-5x7sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.47A 3pocB-5x7sA:
21.8
3pocB-5x7sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 6 THR A1276
SER A 924
TYR A 926
ASP A1273
None
None
None
CA  A1303 (-2.3A)
1.03A 3q70A-5x7sA:
undetectable
3q70A-5x7sA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 VAL A 642
ILE A 699
PHE A 636
THR A 591
SER A 594
None
1.14A 3qfxA-5x7sA:
undetectable
3qfxA-5x7sA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 VAL A 642
ILE A 699
PHE A 636
THR A 591
SER A 594
None
1.13A 3qfxB-5x7sA:
undetectable
3qfxB-5x7sA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ILE A1096
PHE A1030
ALA A1087
VAL A1068
LEU A1044
None
1.21A 3s79A-5x7sA:
undetectable
3s79A-5x7sA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 PHE A1135
VAL A1275
ILE A1190
GLY A1259
LEU A1130
None
1.16A 3t3rA-5x7sA:
undetectable
3t3rA-5x7sA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 GLU A 144
GLY A  37
GLY A  39
ALA A 129
GLY A 149
None
1.13A 3tegA-5x7sA:
undetectable
3tegA-5x7sA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.50A 3topA-5x7sA:
24.7
3topA-5x7sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.49A 3topB-5x7sA:
24.6
3topB-5x7sA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ASP A  49
GLY A 103
ALA A 104
LEU A  70
VAL A  69
None
1.02A 3u7sB-5x7sA:
undetectable
3u7sB-5x7sA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 TYR A 373
TYR A1267
HIS A1181
LEU A1165
MES  A1707 (-3.6A)
MES  A1707 (-4.4A)
None
None
0.91A 3uzzB-5x7sA:
undetectable
3uzzB-5x7sA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 6 PHE A 332
LEU A 340
PRO A 333
GLU A 292
None
1.40A 3vlnA-5x7sA:
undetectable
3vlnA-5x7sA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 LEU A 211
ILE A 258
SER A 261
TYR A 262
ALA A 189
None
1.06A 3vw1D-5x7sA:
undetectable
3vw1D-5x7sA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.48A 3w37A-5x7sA:
18.4
3w37A-5x7sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 ASP A 624
GLY A 674
TYR A 621
None
0.76A 3w9tC-5x7sA:
undetectable
3w9tC-5x7sA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 ASP A 624
GLY A 674
TYR A 621
None
0.76A 3w9tG-5x7sA:
undetectable
3w9tG-5x7sA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.49A 3welA-5x7sA:
18.6
3welA-5x7sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.40A 3wemA-5x7sA:
18.2
3wemA-5x7sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.55A 3wenA-5x7sA:
18.2
3wenA-5x7sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.49A 3weoA-5x7sA:
32.1
3weoA-5x7sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 VAL A1258
TYR A1232
VAL A1275
ILE A1246
None
0.95A 4aftD-5x7sA:
undetectable
4aftE-5x7sA:
undetectable
4aftD-5x7sA:
11.41
4aftE-5x7sA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.32A 4b9zA-5x7sA:
21.7
4b9zA-5x7sA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 LEU A 310
ILE A 354
ILE A 286
GLY A 285
PHE A 282
None
None
None
TB  A1605 (-4.5A)
None
0.90A 4fakA-5x7sA:
undetectable
4fakA-5x7sA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 ASP A  78
ARG A  80
ASP A 213
None
0.80A 4fp9F-5x7sA:
undetectable
4fp9F-5x7sA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 GLN A 703
THR A 715
THR A 714
None
0.76A 4fu9A-5x7sA:
undetectable
4fu9A-5x7sA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 TYR A 373
TYR A1267
HIS A1181
LEU A1165
MES  A1707 (-3.6A)
MES  A1707 (-4.4A)
None
None
0.97A 4jtrA-5x7sA:
3.0
4jtrA-5x7sA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 LEU A  67
ARG A  76
MET A  92
None
0.95A 4m11C-5x7sA:
undetectable
4m11C-5x7sA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 ARG A 869
ASP A 706
ARG A 861
SO4  A1705 (-2.9A)
None
SO4  A1705 (-3.0A)
0.92A 4mx0A-5x7sA:
undetectable
4mx0A-5x7sA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.05A 4qvmK-5x7sA:
undetectable
4qvmL-5x7sA:
undetectable
4qvmK-5x7sA:
10.63
4qvmL-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.05A 4qvpK-5x7sA:
undetectable
4qvpL-5x7sA:
undetectable
4qvpK-5x7sA:
10.55
4qvpL-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.05A 4qvpY-5x7sA:
undetectable
4qvpZ-5x7sA:
undetectable
4qvpY-5x7sA:
10.55
4qvpZ-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 ALA A1028
ALA A 994
GLY A1001
GLY A1002
ASP A1019
None
1.09A 4qvwK-5x7sA:
undetectable
4qvwL-5x7sA:
undetectable
4qvwK-5x7sA:
10.55
4qvwL-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 ALA A1028
ALA A 994
GLY A1001
GLY A1002
ASP A1019
None
1.09A 4qvwY-5x7sA:
undetectable
4qvwZ-5x7sA:
undetectable
4qvwY-5x7sA:
10.55
4qvwZ-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.03A 4qw1K-5x7sA:
undetectable
4qw1L-5x7sA:
undetectable
4qw1K-5x7sA:
10.47
4qw1L-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.03A 4qw1Y-5x7sA:
undetectable
4qw1Z-5x7sA:
undetectable
4qw1Y-5x7sA:
10.47
4qw1Z-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.03A 4qw3K-5x7sA:
undetectable
4qw3L-5x7sA:
undetectable
4qw3K-5x7sA:
10.55
4qw3L-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.03A 4qw3Y-5x7sA:
undetectable
4qw3Z-5x7sA:
undetectable
4qw3Y-5x7sA:
10.55
4qw3Z-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 TRP A 488
GLY A 527
GLY A 490
ASP A 491
SER A 535
None
1.24A 4rtsA-5x7sA:
undetectable
4rtsA-5x7sA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 GLY A1170
GLY A1162
ASN A1163
THR A1243
ALA A1172
None
None
EDO  A1804 ( 4.9A)
None
None
1.15A 4uckB-5x7sA:
undetectable
4uckB-5x7sA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 LEU A 291
GLU A 342
LEU A 340
GLU A 345
LEU A 351
None
1.14A 4wg0H-5x7sA:
undetectable
4wg0I-5x7sA:
undetectable
4wg0J-5x7sA:
undetectable
4wg0H-5x7sA:
1.25
4wg0I-5x7sA:
1.25
4wg0J-5x7sA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 VAL A1209
ILE A1272
ASN A1128
LEU A1277
LEU A1130
None
1.35A 4yvpB-5x7sA:
3.1
4yvpB-5x7sA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 11 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.04A 5bxnY-5x7sA:
undetectable
5bxnZ-5x7sA:
undetectable
5bxnY-5x7sA:
10.47
5bxnZ-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A1028
ALA A 994
GLY A1001
GLY A1002
ASP A1019
None
1.08A 5d0xK-5x7sA:
undetectable
5d0xL-5x7sA:
undetectable
5d0xK-5x7sA:
10.33
5d0xL-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.05A 5d0xK-5x7sA:
undetectable
5d0xL-5x7sA:
undetectable
5d0xK-5x7sA:
10.33
5d0xL-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A1028
ALA A 994
GLY A1001
GLY A1002
ASP A1019
None
1.08A 5d0xY-5x7sA:
undetectable
5d0xZ-5x7sA:
undetectable
5d0xY-5x7sA:
10.33
5d0xZ-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A1028
ALA A 997
GLY A1001
GLY A1002
ALA A1003
None
1.05A 5d0xY-5x7sA:
undetectable
5d0xZ-5x7sA:
undetectable
5d0xY-5x7sA:
10.33
5d0xZ-5x7sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 ALA A 957
ASN A 900
ARG A 667
THR A 687
None
0.87A 5db5A-5x7sA:
undetectable
5db5B-5x7sA:
undetectable
5db5A-5x7sA:
15.27
5db5B-5x7sA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.49A 5eeuA-5x7sA:
undetectable
5eeuB-5x7sA:
undetectable
5eeuA-5x7sA:
4.73
5eeuB-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5eeuB-5x7sA:
undetectable
5eeuC-5x7sA:
undetectable
5eeuB-5x7sA:
4.73
5eeuC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eeuC-5x7sA:
undetectable
5eeuD-5x7sA:
undetectable
5eeuC-5x7sA:
4.73
5eeuD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eeuE-5x7sA:
undetectable
5eeuF-5x7sA:
undetectable
5eeuE-5x7sA:
4.73
5eeuF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5eeuA-5x7sA:
undetectable
5eeuK-5x7sA:
undetectable
5eeuA-5x7sA:
4.73
5eeuK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5eevB-5x7sA:
undetectable
5eevC-5x7sA:
undetectable
5eevB-5x7sA:
4.73
5eevC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eevC-5x7sA:
undetectable
5eevD-5x7sA:
undetectable
5eevC-5x7sA:
4.73
5eevD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eevE-5x7sA:
undetectable
5eevF-5x7sA:
undetectable
5eevE-5x7sA:
4.73
5eevF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eevH-5x7sA:
undetectable
5eevI-5x7sA:
undetectable
5eevH-5x7sA:
4.73
5eevI-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5eevA-5x7sA:
undetectable
5eevK-5x7sA:
undetectable
5eevA-5x7sA:
4.73
5eevK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5eewB-5x7sA:
undetectable
5eewC-5x7sA:
undetectable
5eewB-5x7sA:
4.73
5eewC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eewC-5x7sA:
undetectable
5eewD-5x7sA:
undetectable
5eewC-5x7sA:
4.73
5eewD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eewE-5x7sA:
undetectable
5eewF-5x7sA:
undetectable
5eewE-5x7sA:
4.73
5eewF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5eewA-5x7sA:
undetectable
5eewK-5x7sA:
undetectable
5eewA-5x7sA:
4.73
5eewK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5eexB-5x7sA:
undetectable
5eexC-5x7sA:
undetectable
5eexB-5x7sA:
4.73
5eexC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eexC-5x7sA:
undetectable
5eexD-5x7sA:
undetectable
5eexC-5x7sA:
4.73
5eexD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eexE-5x7sA:
undetectable
5eexF-5x7sA:
1.0
5eexE-5x7sA:
4.73
5eexF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5eeyB-5x7sA:
undetectable
5eeyC-5x7sA:
undetectable
5eeyB-5x7sA:
4.73
5eeyC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eeyC-5x7sA:
undetectable
5eeyD-5x7sA:
undetectable
5eeyC-5x7sA:
4.73
5eeyD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eeyE-5x7sA:
undetectable
5eeyF-5x7sA:
undetectable
5eeyE-5x7sA:
4.73
5eeyF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eeyH-5x7sA:
undetectable
5eeyI-5x7sA:
undetectable
5eeyH-5x7sA:
4.73
5eeyI-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5eeyA-5x7sA:
undetectable
5eeyK-5x7sA:
undetectable
5eeyA-5x7sA:
4.73
5eeyK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5eezB-5x7sA:
undetectable
5eezC-5x7sA:
undetectable
5eezB-5x7sA:
4.73
5eezC-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eezC-5x7sA:
undetectable
5eezD-5x7sA:
undetectable
5eezC-5x7sA:
4.73
5eezD-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eezE-5x7sA:
undetectable
5eezF-5x7sA:
undetectable
5eezE-5x7sA:
4.73
5eezF-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5eezH-5x7sA:
undetectable
5eezI-5x7sA:
undetectable
5eezH-5x7sA:
4.73
5eezI-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5eezJ-5x7sA:
undetectable
5eezK-5x7sA:
undetectable
5eezJ-5x7sA:
4.73
5eezK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5eezA-5x7sA:
undetectable
5eezK-5x7sA:
undetectable
5eezA-5x7sA:
4.73
5eezK-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5ef0B-5x7sA:
undetectable
5ef0C-5x7sA:
undetectable
5ef0B-5x7sA:
4.73
5ef0C-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef0C-5x7sA:
undetectable
5ef0D-5x7sA:
undetectable
5ef0C-5x7sA:
4.73
5ef0D-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef0E-5x7sA:
undetectable
5ef0F-5x7sA:
1.0
5ef0E-5x7sA:
4.73
5ef0F-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef0H-5x7sA:
undetectable
5ef0I-5x7sA:
undetectable
5ef0H-5x7sA:
4.73
5ef0I-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef0J-5x7sA:
undetectable
5ef0K-5x7sA:
undetectable
5ef0J-5x7sA:
4.73
5ef0K-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef1B-5x7sA:
undetectable
5ef1C-5x7sA:
undetectable
5ef1B-5x7sA:
4.73
5ef1C-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef1C-5x7sA:
undetectable
5ef1D-5x7sA:
undetectable
5ef1C-5x7sA:
4.73
5ef1D-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef1E-5x7sA:
undetectable
5ef1F-5x7sA:
undetectable
5ef1E-5x7sA:
4.73
5ef1F-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef1H-5x7sA:
undetectable
5ef1I-5x7sA:
undetectable
5ef1H-5x7sA:
4.73
5ef1I-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef1J-5x7sA:
undetectable
5ef1K-5x7sA:
undetectable
5ef1J-5x7sA:
4.73
5ef1K-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5ef1A-5x7sA:
undetectable
5ef1K-5x7sA:
undetectable
5ef1A-5x7sA:
4.73
5ef1K-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef2B-5x7sA:
undetectable
5ef2C-5x7sA:
undetectable
5ef2B-5x7sA:
4.73
5ef2C-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef2C-5x7sA:
undetectable
5ef2D-5x7sA:
undetectable
5ef2C-5x7sA:
4.73
5ef2D-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef2E-5x7sA:
undetectable
5ef2F-5x7sA:
undetectable
5ef2E-5x7sA:
4.73
5ef2F-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef2H-5x7sA:
undetectable
5ef2I-5x7sA:
undetectable
5ef2H-5x7sA:
4.73
5ef2I-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef2J-5x7sA:
undetectable
5ef2K-5x7sA:
undetectable
5ef2J-5x7sA:
4.73
5ef2K-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 ALA A 929
THR A 685
THR A 687
ILE A 961
THR A 550
None
1.49A 5ef2A-5x7sA:
undetectable
5ef2K-5x7sA:
undetectable
5ef2A-5x7sA:
4.73
5ef2K-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.46A 5ef3B-5x7sA:
undetectable
5ef3C-5x7sA:
undetectable
5ef3B-5x7sA:
4.73
5ef3C-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef3C-5x7sA:
undetectable
5ef3D-5x7sA:
undetectable
5ef3C-5x7sA:
4.73
5ef3D-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef3E-5x7sA:
undetectable
5ef3F-5x7sA:
undetectable
5ef3E-5x7sA:
4.73
5ef3F-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.48A 5ef3H-5x7sA:
undetectable
5ef3I-5x7sA:
undetectable
5ef3H-5x7sA:
4.73
5ef3I-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 9 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
None
1.47A 5ef3J-5x7sA:
0.8
5ef3K-5x7sA:
undetectable
5ef3J-5x7sA:
4.73
5ef3K-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 6 TYR A 248
TYR A 231
GLY A 149
GLU A 144
None
EDO  A1801 (-3.2A)
None
None
1.08A 5emlA-5x7sA:
3.1
5emlA-5x7sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_A_ACTA1229_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 4 VAL A 932
GLU A1274
THR A1276
GLU A1206
None
1.18A 5g5hA-5x7sA:
undetectable
5g5hA-5x7sA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 TRP A 427
ASP A 429
ASP A 491
PHE A 533
HIS A 565
None
0.52A 5iefA-5x7sA:
8.8
5iefA-5x7sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 4 ARG A 474
TRP A 488
ASP A 529
ARG A 563
None
0.95A 5iefA-5x7sA:
10.0
5iefA-5x7sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ILE A1096
PHE A1030
ALA A1087
VAL A1068
LEU A1044
None
1.22A 5jkvA-5x7sA:
undetectable
5jkvA-5x7sA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 THR A 205
SER A 204
TYR A 166
None
0.82A 5jsdA-5x7sA:
3.2
5jsdA-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 THR A 205
SER A 204
TYR A 166
None
0.83A 5jsdB-5x7sA:
undetectable
5jsdB-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 THR A 205
SER A 204
TYR A 166
None
0.83A 5jsdC-5x7sA:
undetectable
5jsdC-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 THR A 205
SER A 204
TYR A 166
None
0.82A 5jseA-5x7sA:
undetectable
5jseA-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 THR A 205
SER A 204
TYR A 166
None
0.82A 5jseB-5x7sA:
undetectable
5jseB-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 THR A 205
SER A 204
TYR A 166
None
0.82A 5jseC-5x7sA:
undetectable
5jseC-5x7sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 SER A 545
SER A1161
PHE A 496
EDO  A1804 (-3.8A)
None
None
0.95A 5mugA-5x7sA:
undetectable
5mugA-5x7sA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 4 HIS A 565
GLY A 532
ARG A 572
THR A 494
None
1.44A 5nn4A-5x7sA:
31.7
5nn4A-5x7sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.52A 5nn6A-5x7sA:
19.5
5nn6A-5x7sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 TRP A 427
ASP A 429
ARG A 474
ASP A 491
PHE A 533
HIS A 565
None
0.44A 5nn8A-5x7sA:
33.0
5nn8A-5x7sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ALA A  46
GLU A  66
LEU A  53
VAL A  69
ASP A  78
None
1.26A 5vlmC-5x7sA:
undetectable
5vlmC-5x7sA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 VAL A1068
LEU A1021
ALA A1058
LEU A1113
LEU A1044
None
1.34A 5x23A-5x7sA:
undetectable
5x23A-5x7sA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
3 / 3 TYR A 249
ASP A  78
ASP A 213
None
0.70A 5x6yA-5x7sA:
undetectable
5x6yA-5x7sA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 10 ASP A 429
GLU A 430
ARG A 474
TRP A 488
ASN A 567
None
1.06A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
10 / 10 TRP A 427
ASP A 429
GLU A 430
ARG A 474
TRP A 488
ASP A 491
TRP A 504
PHE A 533
ASN A 534
HIS A 565
None
0.23A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1401_2
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
9 / 9 GLN A 174
GLN A 194
TRP A 284
ASP A 311
TYR A 312
ILE A 354
LYS A 356
GLY A 437
SER A 438
None
0.39A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1401_2
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 9 GLN A 193
GLN A 194
TRP A 284
ASP A 311
TYR A 312
ILE A 354
None
1.47A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 5 TYR A 218
TYR A 230
GLY A 232
GLY A 233
None
0.12A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
7 / 7 ASN A 875
HIS A 876
ASP A 886
ASP A 889
TRP A 943
GLY A 975
ASN A 977
None
0.17A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 7 ASP A 491
ASP A 529
GLY A 532
ASN A 534
None
1.12A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 7 HIS A1009
ASP A1019
TRP A1077
ASN A1109
None
0.27A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
12 / 12 ARG A 362
ARG A 368
TYR A 373
ASP A1160
LEU A1165
GLU A1169
ARG A1177
TYR A1179
HIS A1181
ASN A1213
THR A1269
HIS A1271
None
None
MES  A1707 (-3.6A)
None
None
None
None
None
None
MES  A1707 (-3.4A)
None
None
0.39A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ARG A 362
ASP A1160
LEU A1165
GLU A1169
ARG A1177
HIS A1271
None
1.05A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
7 / 12 TYR A 372
LEU A1165
GLU A1169
ARG A1177
HIS A1181
THR A1269
HIS A1271
None
1.35A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 6 TRP A1148
SER A1189
HIS A1191
ARG A1220
GLU A1222
TYR A1261
None
0.28A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
9 / 9 GLN A 174
GLN A 194
TRP A 284
ASP A 311
TYR A 312
ILE A 354
LYS A 356
GLY A 437
SER A 438
None
0.30A 5x7pA-5x7sA:
59.0
5x7pA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 6 TYR A 218
GLU A 228
TYR A 230
GLY A 232
GLY A 233
None
0.16A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 5 HIS A 876
ASP A 889
TRP A 943
GLY A 975
ASN A 977
None
0.17A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
12 / 12 ARG A 362
ARG A 368
ASP A1160
GLY A1162
LEU A1165
GLU A1169
ARG A1177
TYR A1179
HIS A1181
ASN A1213
THR A1269
HIS A1271
None
None
None
None
None
None
None
None
None
MES  A1707 (-3.4A)
None
None
0.61A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
7 / 12 ARG A 362
ASP A1160
GLY A1162
LEU A1165
GLU A1169
ARG A1177
HIS A1271
None
0.97A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 GLY A1170
GLU A1169
ARG A1177
ASN A1213
THR A1269
HIS A1271
None
None
None
MES  A1707 (-3.4A)
None
None
1.40A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 6 TRP A1148
SER A1189
HIS A1191
ARG A1220
GLU A1222
TYR A1261
None
0.30A 5x7pB-5x7sA:
58.3
5x7pB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 6 TRP A1148
SER A1189
HIS A1191
ARG A1220
GLU A1222
TYR A1261
None
0.24A 5x7qA-5x7sA:
45.6
5x7qA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 6 TRP A1148
SER A1189
HIS A1191
ARG A1220
GLU A1222
TYR A1261
None
0.30A 5x7qB-5x7sA:
56.2
5x7qB-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 6 TRP A1148
SER A1189
HIS A1191
ARG A1220
GLU A1222
TYR A1261
None
0.27A 5x7rA-5x7sA:
58.3
5x7rA-5x7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 6 TRP A1148
SER A1189
HIS A1191
ARG A1220
GLU A1222
TYR A1261
None
0.30A 5x7rB-5x7sA:
56.2
5x7rB-5x7sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 PHE A 692
ILE A 677
LEU A 657
ALA A 633
LEU A 617
None
1.37A 5zwrB-5x7sA:
undetectable
5zwrB-5x7sA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 LEU A1056
LEU A1110
THR A1055
PRO A1073
GLY A1051
None
1.11A 6b0lB-5x7sA:
undetectable
6b0lB-5x7sA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
TRP A 488
PHE A 533
HIS A 565
None
0.42A 6c9xA-5x7sA:
21.0
6c9xA-5x7sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
TRP A 488
PHE A 533
HIS A 565
None
0.44A 6c9xB-5x7sA:
22.3
6c9xB-5x7sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.37A 6c9zA-5x7sA:
17.2
6c9zA-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 ASP A 429
ARG A 474
TRP A 488
PHE A 533
HIS A 565
None
0.40A 6c9zB-5x7sA:
22.7
6c9zB-5x7sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.44A 6ca1A-5x7sA:
21.5
6ca1A-5x7sA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.39A 6ca1B-5x7sA:
21.4
6ca1B-5x7sA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.37A 6ca3A-5x7sA:
23.0
6ca3A-5x7sA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
6 / 12 ASP A 429
ARG A 474
TRP A 488
ASP A 491
PHE A 533
HIS A 565
None
0.38A 6ca3B-5x7sA:
17.2
6ca3B-5x7sA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 5 ASN A1213
GLY A1158
HIS A1181
ASP A1183
MES  A1707 (-3.4A)
None
None
TB  A1608 (-2.4A)
1.17A 6gh9A-5x7sA:
undetectable
6gh9A-5x7sA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
5 / 12 VAL A 718
PHE A 721
ILE A 720
VAL A 824
ILE A 782
None
1.43A 6gsdA-5x7sA:
undetectable
6gsdA-5x7sA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp.
598K)
4 / 8 ARG A  76
GLU A 247
ASP A  78
GLU A  66
None
0.99A 6mn4D-5x7sA:
undetectable
6mn4D-5x7sA:
12.26