SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.37A 1a52A-5x87A:
undetectable		 1a52A-5x87A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.39A 1a52B-5x87A:
undetectable		 1a52B-5x87A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 9 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.37A 1ereD-5x87A:
undetectable		 1ereD-5x87A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		4 / 6 TRP A 123
LEU A 141
LEU A 142
PRO A 143
 None
 1.30A 1hz4A-5x87A:
2.8		 1hz4A-5x87A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.33A 1qkuA-5x87A:
undetectable		 1qkuA-5x87A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.33A 1qkuB-5x87A:
undetectable		 1qkuB-5x87A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.33A 1qkuC-5x87A:
undetectable		 1qkuC-5x87A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 12 SER A 246
ILE A 245
GLY A  61
VAL A  54
ALA A  55
 None
 1.12A 1tlsB-5x87A:
undetectable		 1tlsB-5x87A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 12 SER A 246
ILE A 245
GLY A  61
VAL A  54
ALA A  55
 None
 1.15A 1tsnA-5x87A:
undetectable		 1tsnA-5x87A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 9 LEU A 141
ASP A 137
ARG A 140
LYS A 126
ASN A 277
 None
 1.46A 2o1oA-5x87A:
undetectable		 2o1oA-5x87A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.43A 2ocfA-5x87A:
undetectable		 2ocfA-5x87A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.35A 3erdB-5x87A:
undetectable		 3erdB-5x87A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 12 SER A 246
ILE A 245
GLY A  61
VAL A  54
ALA A  55
 None
 1.19A 4foxD-5x87A:
undetectable		 4foxD-5x87A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 11 LEU A 196
ILE A 150
SER A 153
PHE A 121
LEU A 138
 None
 1.14A 4lhmA-5x87A:
undetectable		 4lhmA-5x87A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 9 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.37A 5dx3B-5x87A:
undetectable		 5dx3B-5x87A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.38A 5dxbA-5x87A:
undetectable		 5dxbA-5x87A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.41A 5dxeB-5x87A:
undetectable		 5dxeB-5x87A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		4 / 7 LEU A 250
ASP A 253
ALA A 256
LEU A 259
 None
 1.05A 5nwvA-5x87A:
undetectable		 5nwvA-5x87A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.35A 5wgqB-5x87A:
undetectable		 5wgqB-5x87A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 10 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.39A 6cbzB-5x87A:
undetectable		 6cbzB-5x87A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		4 / 5 GLU A 144
VAL A 147
LEU A 138
HIS A 127
 None
 1.49A 6dyoA-5x87A:
undetectable		 6dyoA-5x87A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5x87 BESTROPHIN
(Klebsiella
pneumoniae) 		5 / 9 LEU A 250
PHE A  57
SER A  58
LEU A  60
ILE A  64
 None
 1.24A 6fdyU-5x87A:
undetectable		 6fdyU-5x87A:
25.22