SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		4 / 7 ASP A 141
HIS A 119
GLY A 149
GLY A 148
 None
 0.91A 1ekjE-5x88A:
2.6
1ekjF-5x88A:
2.5		 1ekjE-5x88A:
undetectable
1ekjF-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		3 / 3 GLN A  63
ILE A 151
HIS A 119
 None
 0.68A 1fm9A-5x88A:
undetectable		 1fm9A-5x88A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		4 / 6 PHE A  56
GLU A 195
LEU A 194
VAL A 107
 None
 1.03A 1hk1A-5x88A:
undetectable		 1hk1A-5x88A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		3 / 3 GLN A  63
ILE A 151
HIS A 119
 None
 0.71A 1k74A-5x88A:
undetectable		 1k74A-5x88A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		3 / 3 ASP A  20
ASP A  17
LYS A 100
 None
 1.17A 1lqtB-5x88A:
4.0		 1lqtB-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		3 / 3 ASP A  20
ASP A  17
LYS A 100
 None
 1.16A 1lquB-5x88A:
3.7		 1lquB-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		6 / 12 ILE A 122
PHE A  94
ILE A 151
PHE A 154
VAL A 137
LEU A 138
 None
 1.35A 1qhsA-5x88A:
4.3		 1qhsA-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		6 / 12 ILE A 133
ILE A 122
ILE A 151
PHE A 154
VAL A 137
LEU A 138
 None
 1.05A 1qhsA-5x88A:
4.3		 1qhsA-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		6 / 12 ILE A 133
ILE A 122
PHE A  94
ILE A 151
VAL A 137
LEU A 138
 None
 1.24A 1qhyA-5x88A:
4.3		 1qhyA-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		6 / 11 GLY A 114
ALA A 115
VAL A 136
ILE A 151
GLY A 120
ILE A  87
 None
 1.22A 1sdvB-5x88A:
undetectable		 1sdvB-5x88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		5 / 12 GLY A 114
ALA A 115
VAL A 136
ILE A 151
GLY A 120
 None
 1.16A 2avsB-5x88A:
undetectable		 2avsB-5x88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		5 / 12 THR A  83
ALA A 116
ALA A 121
VAL A  65
GLY A  66
 None
 1.23A 2ve3B-5x88A:
undetectable		 2ve3B-5x88A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		5 / 12 ASP A 141
VAL A 136
ILE A 151
GLY A 120
ILE A  87
 None
 0.85A 3so9B-5x88A:
undetectable		 3so9B-5x88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		5 / 12 ALA A 115
VAL A 136
ILE A 151
GLY A 120
ILE A  87
 None
 1.05A 3spkB-5x88A:
undetectable		 3spkB-5x88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		5 / 9 THR A  27
THR A  99
LEU A  18
LEU A  96
VAL A 129
 None
 1.27A 4c9kA-5x88A:
undetectable		 4c9kA-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		6 / 12 GLY A 114
ALA A 115
VAL A 136
ILE A 151
GLY A 120
ILE A  87
 None
 1.33A 6dj1B-5x88A:
undetectable		 6dj1B-5x88A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 5x88 CUTINASE
(Malbranchea
cinnamomea) 		6 / 12 GLY A 114
ALA A 115
VAL A 136
ILE A 151
GLY A 120
ILE A  87
 None
 1.30A 6dj2B-5x88A:
undetectable		 6dj2B-5x88A:
21.11