SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		3 / 3 ALA A  13
VAL A 207
TRP A   8
 PEG  A 510 ( 3.7A)
None
None
 0.78A 1tkqA-5x8gA:
undetectable		 1tkqA-5x8gA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		3 / 3 LYS A 160
ASP A 367
ASP A 381
 None
 1.03A 2br4A-5x8gA:
undetectable		 2br4A-5x8gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 8 ILE A 197
GLY A 264
GLY A 287
THR A 289
 CA  A 505 ( 4.5A)
S0N  A 501 (-4.1A)
S0N  A 501 (-4.5A)
CA  A 505 (-3.3A)
 0.53A 2wd9B-5x8gA:
42.3		 2wd9B-5x8gA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 10 THR A 152
ILE A 197
GLY A 264
GLY A 287
THR A 289
 None
CA  A 505 ( 4.5A)
S0N  A 501 (-4.1A)
S0N  A 501 (-4.5A)
CA  A 505 (-3.3A)
 0.73A 2wd9C-5x8gA:
41.9		 2wd9C-5x8gA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 LEU A 261
SER A 285
SER A 198
SER A 201
LEU A 247
 S0N  A 501 (-4.3A)
S0N  A 501 ( 4.4A)
S0N  A 501 (-2.8A)
S0N  A 501 ( 4.0A)
None
 1.18A 2zlcA-5x8gA:
undetectable		 2zlcA-5x8gA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		3 / 3 LEU A 180
VAL A 233
ARG A 258
 None
None
PEG  A 508 ( 4.1A)
 0.72A 3b0wB-5x8gA:
undetectable		 3b0wB-5x8gA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 11 LEU A 189
ALA A 238
PRO A 254
ILE A 228
ILE A 236
 None
 1.02A 3ebzA-5x8gA:
undetectable		 3ebzA-5x8gA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		6 / 12 ALA A  57
LEU A 149
LEU A  59
SER A  99
GLY A 100
SER A 101
 None
 1.33A 3g2oA-5x8gA:
undetectable		 3g2oA-5x8gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		3 / 3 MET A 235
MET A 242
PHE A 283
 None
S0N  A 501 ( 4.1A)
None
 1.13A 3gn8A-5x8gA:
undetectable		 3gn8A-5x8gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 ALA A 191
ARG A 187
ILE A 257
PRO A 254
SER A 256
 None
 1.16A 3nrrA-5x8gA:
undetectable		 3nrrA-5x8gA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 ALA A 191
ARG A 187
ILE A 257
PRO A 254
SER A 256
 None
 1.09A 3nrrB-5x8gA:
undetectable		 3nrrB-5x8gA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 LEU A 449
ALA A 450
GLU A  91
ILE A 388
GLY A 391
 None
None
None
None
S0N  A 501 (-4.0A)
 1.05A 3q95B-5x8gA:
undetectable		 3q95B-5x8gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 8 LEU A  83
ALA A  57
SER A 101
SER A  99
 None
 1.09A 3rodA-5x8gA:
undetectable		 3rodA-5x8gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 11 LEU A 189
ALA A 238
PRO A 254
ILE A 228
ILE A 236
 None
 1.05A 3s53B-5x8gA:
undetectable		 3s53B-5x8gA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 7 TRP A 188
TYR A 209
ARG A 187
MET A 235
 None
 1.48A 3wipA-5x8gA:
undetectable
3wipB-5x8gA:
undetectable		 3wipA-5x8gA:
19.14
3wipB-5x8gA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 7 TRP A 188
TYR A 209
ARG A 187
MET A 235
 None
 1.46A 3wipF-5x8gA:
undetectable
3wipG-5x8gA:
undetectable		 3wipF-5x8gA:
19.14
3wipG-5x8gA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 11 ALA A  80
PHE A  35
LEU A  34
VAL A  67
THR A 148
 None
PEG  A 510 (-3.9A)
None
None
None
 1.40A 4kyaA-5x8gA:
undetectable		 4kyaA-5x8gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 ALA A  80
PHE A  35
LEU A  34
VAL A  67
THR A 148
 None
PEG  A 510 (-3.9A)
None
None
None
 1.35A 4kyaB-5x8gA:
undetectable		 4kyaB-5x8gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 11 ALA A  80
PHE A  35
LEU A  34
VAL A  67
THR A 148
 None
PEG  A 510 (-3.9A)
None
None
None
 1.41A 4kyaE-5x8gA:
undetectable		 4kyaE-5x8gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 LEU A  22
LEU A   9
VAL A  70
MET A  66
ILE A 208
 None
MG  A 503 ( 4.3A)
None
None
None
 1.25A 4okbA-5x8gA:
undetectable		 4okbA-5x8gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 6 LEU A 386
HIS A 196
TYR A 452
GLU A 392
 None
S0N  A 501 (-4.0A)
None
S0N  A 501 (-4.0A)
 0.84A 4pahA-5x8gA:
undetectable		 4pahA-5x8gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 8 ASN A 342
PRO A 341
PHE A 171
TYR A 209
 None
 1.29A 5amkA-5x8gA:
undetectable		 5amkA-5x8gA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 7 ASN A 342
PRO A 341
PHE A 171
TYR A 209
 None
 1.34A 5amkB-5x8gA:
undetectable		 5amkB-5x8gA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 6 PRO A 159
GLY A 161
ARG A 350
PHE A  94
 None
 1.46A 5jcnB-5x8gA:
undetectable		 5jcnB-5x8gA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 7 VAL A 213
LEU A  83
PHE A 195
PHE A 204
 None
 0.97A 6aycA-5x8gA:
undetectable		 6aycA-5x8gA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		5 / 12 VAL A 124
ASP A 123
ALA A  69
LEU A  82
ARG A  92
 None
 1.23A 6ew0F-5x8gA:
undetectable		 6ew0F-5x8gA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5x8g 2-SUCCINYLBENZOATE--
COA LIGASE
(Bacillus
subtilis) 		4 / 6 LEU A 386
HIS A 196
TYR A 452
GLU A 392
 None
S0N  A 501 (-4.0A)
None
S0N  A 501 (-4.0A)
 0.93A 6pahA-5x8gA:
undetectable		 6pahA-5x8gA:
22.11