SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		4 / 6 ASP A  94
LEU A  97
GLU A  39
ARG A 172
 None
 1.02A 1mt1A-5x8jA:
undetectable
1mt1F-5x8jA:
undetectable		 1mt1A-5x8jA:
19.28
1mt1F-5x8jA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		4 / 5 GLU A  39
ARG A 172
ASP A  94
LEU A  97
 None
 0.98A 1n13B-5x8jA:
undetectable
1n13C-5x8jA:
undetectable		 1n13B-5x8jA:
22.52
1n13C-5x8jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		4 / 7 ASP A  94
LEU A  97
GLU A  39
ARG A 172
 None
 0.96A 1n13I-5x8jA:
undetectable
1n13L-5x8jA:
undetectable		 1n13I-5x8jA:
19.28
1n13L-5x8jA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		5 / 10 ARG A  21
ILE A 189
PRO A 181
GLU A 182
ILE A 185
 None
 1.30A 2dm6A-5x8jA:
undetectable
2dm6B-5x8jA:
undetectable		 2dm6A-5x8jA:
14.81
2dm6B-5x8jA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		5 / 9 GLY A  13
SER A  14
LEU A 130
ASP A  12
GLU A   9
 FMT  A 201 (-3.3A)
FMT  A 201 (-4.9A)
None
None
None
 1.41A 2j2pB-5x8jA:
undetectable
2j2pC-5x8jA:
undetectable		 2j2pB-5x8jA:
16.97
2j2pC-5x8jA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 122
GLY A  42
PRO A  45
LEU A  44
GLU A  71
 None
 1.46A 5emlA-5x8jA:
undetectable		 5emlA-5x8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		4 / 7 LEU A  81
THR A   7
ASP A  94
LEU A  78
 None
 0.97A 5jq7B-5x8jA:
undetectable		 5jq7B-5x8jA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5x8j THYMIDYLATE KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  24
PRO A  33
GLY A  31
ASP A  90
ALA A  20
 None
None
None
FMT  A 201 ( 4.6A)
None
 1.03A 5zvgB-5x8jA:
undetectable		 5zvgB-5x8jA:
undetectable