SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 THR A 380
GLU A 382
LEU A 447
GLY A 441
MET A  62
 None
 1.33A 1d4fC-5x8oA:
undetectable		 1d4fC-5x8oA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 GLY A  73
VAL A  43
LEU A  39
LEU A  45
LEU A 229
 None
 1.24A 1mx1C-5x8oA:
undetectable		 1mx1C-5x8oA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 GLY A 449
LEU A 447
LEU A 451
ILE A 360
ILE A  47
 None
 1.03A 2f8dA-5x8oA:
undetectable		 2f8dA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 ILE A 105
ALA A 114
ARG A 115
ALA A 153
 None
 0.91A 3hrdA-5x8oA:
undetectable
3hrdB-5x8oA:
undetectable		 3hrdA-5x8oA:
10.84
3hrdB-5x8oA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ASN A 193
ILE A  99
THR A 208
ASP A 211
LYS A 214
 None
GTP  A 601 ( 4.2A)
GTP  A 601 (-3.9A)
GTP  A 601 (-2.8A)
GTP  A 601 (-3.0A)
 1.10A 3kpbA-5x8oA:
15.3		 3kpbA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ILE A 144
THR A 146
ASP A 149
THR A 164
PRO A 195
 None
 0.73A 3kpbA-5x8oA:
15.3		 3kpbA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ILE A 144
THR A 146
ASP A 149
THR A 164
PRO A 195
 None
 0.69A 3kpbC-5x8oA:
15.6		 3kpbC-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ILE A 144
ASP A 149
THR A 164
VAL A 194
PRO A 195
 None
 0.69A 3kpdC-5x8oA:
15.6		 3kpdC-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 0.86A 3n8wA-5x8oA:
undetectable		 3n8wA-5x8oA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 0.82A 3n8zA-5x8oA:
undetectable		 3n8zA-5x8oA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 0.92A 3rr3A-5x8oA:
undetectable		 3rr3A-5x8oA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 0.93A 3rr3B-5x8oA:
undetectable		 3rr3B-5x8oA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 LEU A 230
GLY A  73
ILE A 349
VAL A  50
ALA A 253
 None
 1.12A 4a6eA-5x8oA:
undetectable		 4a6eA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 VAL A 440
VAL A 444
LEU A 447
VAL A 371
 None
 1.09A 4e1gB-5x8oA:
undetectable		 4e1gB-5x8oA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 ASN A 290
GLY A 313
CYH A 318
THR A 320
 None
 0.76A 4fo4B-5x8oA:
42.3		 4fo4B-5x8oA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		6 / 9 ASP A 259
ASN A 290
GLY A 313
CYH A 318
THR A 320
ASP A 351
 None
 0.92A 4fxsA-5x8oA:
44.6		 4fxsA-5x8oA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ARG A 247
ASP A 241
ASP A 259
 None
 0.87A 4kicB-5x8oA:
undetectable		 4kicB-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 LEU A 275
ASP A 241
ARG A 244
ILE A  81
 None
 1.47A 4mwrA-5x8oA:
undetectable		 4mwrA-5x8oA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 LEU A 230
VAL A  50
ILE A 349
GLY A 307
ILE A  72
 None
 0.99A 4njtA-5x8oA:
undetectable		 4njtA-5x8oA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 LEU A 230
VAL A  50
ILE A 349
GLY A 307
ILE A  72
 None
 0.93A 4njtC-5x8oA:
undetectable		 4njtC-5x8oA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 1.03A 4ph9A-5x8oA:
undetectable		 4ph9A-5x8oA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 1.03A 4ph9B-5x8oA:
undetectable		 4ph9B-5x8oA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 LEU A 230
VAL A  50
ILE A 349
GLY A 307
ILE A  72
 None
 0.89A 4rvjA-5x8oA:
undetectable		 4rvjA-5x8oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 11 LEU A 230
VAL A  50
ILE A 349
GLY A 307
ILE A  72
 None
 0.90A 4rvjC-5x8oA:
undetectable		 4rvjC-5x8oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A  27
ALA A 460
THR A  37
GLY A 449
LEU A 451
 None
 1.00A 5m54E-5x8oA:
2.0		 5m54E-5x8oA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 VAL A  27
ALA A 460
THR A  37
GLY A 449
LEU A 451
 None
 1.12A 5m5cB-5x8oA:
undetectable		 5m5cB-5x8oA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 VAL A  27
ALA A 460
THR A  37
GLY A 449
LEU A 451
 None
 1.12A 5m5cE-5x8oA:
undetectable		 5m5cE-5x8oA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 ASN A 290
ALA A 261
VAL A 312
ASP A 259
 None
 1.16A 5umd2-5x8oA:
undetectable
5umdF-5x8oA:
undetectable		 5umd2-5x8oA:
21.69
5umdF-5x8oA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 LEU A 451
GLY A 450
SER A 453
SER A 456
 None
 1.14A 5uunB-5x8oA:
undetectable		 5uunB-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 PRO A 439
GLY A 438
THR A 380
LYS A 435
 None
 1.20A 5x23A-5x8oA:
undetectable		 5x23A-5x8oA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 ILE A 287
ASN A  42
THR A 370
PRO A 347
 None
 1.04A 5x23A-5x8oA:
undetectable		 5x23A-5x8oA:
10.02