SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5x8t PROTEIN L3
(Spinacia
oleracea) 		5 / 8 HIS D 156
GLY D 161
THR D 124
MET D 165
LEU D 168
 C  A2803 ( 3.7A)
None
None
None
C  A2651 ( 4.7A)
 1.23A 1aegA-5x8tD:
undetectable		 1aegA-5x8tD:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 10 ALA E 168
LEU E 240
LEU E 161
ALA E 160
ILE E 165
 None
 1.25A 1g5yC-5x8tE:
undetectable		 1g5yC-5x8tE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5x8t PROTEIN L3
(Spinacia
oleracea) 		5 / 12 GLY D 201
VAL D 282
GLY D  94
HIS D 167
LEU D 168
 None
None
None
None
C  A2651 ( 4.7A)
 0.92A 1kiaC-5x8tD:
undetectable		 1kiaC-5x8tD:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 GLY Q 191
VAL Q 192
GLU Q 193
ILE Q 187
ARG Q 212
 None
 1.35A 1vhwA-5x8tQ:
undetectable
1vhwD-5x8tQ:
undetectable		 1vhwA-5x8tQ:
21.55
1vhwD-5x8tQ:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 GLY Q 191
VAL Q 192
GLU Q 193
ILE Q 187
ARG Q 212
 None
 1.34A 1vhwC-5x8tQ:
undetectable
1vhwE-5x8tQ:
undetectable		 1vhwC-5x8tQ:
21.55
1vhwE-5x8tQ:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ARG Q 212
GLY Q 191
VAL Q 192
GLU Q 193
ILE Q 187
 None
 1.33A 1vhwA-5x8tQ:
undetectable
1vhwD-5x8tQ:
undetectable		 1vhwA-5x8tQ:
21.55
1vhwD-5x8tQ:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ARG Q 212
GLY Q 191
VAL Q 192
GLU Q 193
ILE Q 187
 None
 1.34A 1vhwC-5x8tQ:
undetectable
1vhwE-5x8tQ:
undetectable		 1vhwC-5x8tQ:
21.55
1vhwE-5x8tQ:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 ALA L  33
TYR L  32
ARG L  34
TYR L  79
 None
G  A2745 ( 4.0A)
G  A2690 ( 3.2A)
None
 1.18A 2ajvH-5x8tL:
undetectable
2ajvL-5x8tL:
undetectable		 2ajvH-5x8tL:
18.92
2ajvL-5x8tL:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ASN L  29
GLY L  36
ILE L   2
ARG L  34
THR L  65
 G  A2691 ( 4.0A)
None
None
G  A2690 ( 3.2A)
None
 1.13A 2f9wA-5x8tL:
undetectable
2f9wB-5x8tL:
undetectable		 2f9wA-5x8tL:
20.66
2f9wB-5x8tL:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5x8t 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 VAL U 157
VAL U 159
ILE U 176
LEU U 178
GLU U 186
 None
 1.24A 2gj5A-5x8tU:
undetectable		 2gj5A-5x8tU:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 PHE E 182
PRO E 185
LYS E 186
THR E 187
 None
None
None
C  A 329 ( 3.4A)
 1.22A 2m2oB-5x8tE:
undetectable		 2m2oB-5x8tE:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 LEU E 161
ARG E 258
ILE E 165
 None
C  A 629 ( 3.6A)
None
 0.57A 2xn5B-5x8tE:
undetectable		 2xn5B-5x8tE:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 THR E  68
VAL E 169
SER E 167
LEU E 245
VAL E 246
 None
 1.20A 2zbzA-5x8tE:
undetectable		 2zbzA-5x8tE:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 9 THR E  68
VAL E 169
SER E 167
LEU E 245
ILE E  57
 None
 1.26A 3cv9A-5x8tE:
undetectable		 3cv9A-5x8tE:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5x8t PROTEIN L27
(Spinacia
oleracea) 		4 / 8 ILE X  94
ALA X  91
VAL X 123
VAL X 135
 None
A  A2371 ( 4.3A)
None
None
 0.86A 3me6B-5x8tX:
undetectable		 3me6B-5x8tX:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 5x8t PROTEIN L27
(Spinacia
oleracea) 		5 / 10 GLY X  90
ALA X  91
ILE X 119
VAL X 135
ILE X  93
 A  A2369 ( 3.5A)
A  A2371 ( 4.3A)
None
None
None
 0.98A 3nu6B-5x8tX:
undetectable		 3nu6B-5x8tX:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5x8t PROTEIN L3
(Spinacia
oleracea) 		5 / 12 GLY D  91
VAL D 123
ALA D  88
ASP D 198
PHE D 191
 None
 1.29A 3qowA-5x8tD:
undetectable		 3qowA-5x8tD:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 GLY Q 146
ASP Q 147
ARG Q 144
GLN Q 173
 None
None
C  W  71 ( 3.4A)
U  A2701 ( 4.4A)
 1.49A 3qx3B-5x8tQ:
undetectable		 3qx3B-5x8tQ:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 VAL Q 149
ILE Q 151
THR Q 180
THR Q 179
 None
None
U  A2701 ( 4.0A)
None
 1.03A 3tneB-5x8tQ:
undetectable		 3tneB-5x8tQ:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5x8t PROTEIN L3
(Spinacia
oleracea) 		4 / 5 GLY D 140
THR D 124
ILE D 163
VAL D 162
 None
 0.85A 3wriA-5x8tD:
undetectable		 3wriA-5x8tD:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5x8t PROTEIN L3
(Spinacia
oleracea) 		4 / 5 GLY D 140
THR D 124
ILE D 163
VAL D 162
 None
 0.85A 3wriB-5x8tD:
undetectable		 3wriB-5x8tD:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 11 ILE L  87
LEU L   8
ASP L  37
GLY L  36
PHE L 110
 None
 1.25A 4fogC-5x8tL:
undetectable		 4fogC-5x8tL:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ILE L  87
LEU L   8
ASP L  37
GLY L  36
PHE L 110
 None
 1.13A 4foxB-5x8tL:
undetectable		 4foxB-5x8tL:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 5x8t PROTEIN L17
(Spinacia
oleracea) 		5 / 12 LEU O  89
VAL O  86
LEU O  39
THR O  36
THR O  35
 None
 0.92A 4k13A-5x8tO:
undetectable		 4k13A-5x8tO:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5x8t PROTEIN L29
(Spinacia
oleracea) 		3 / 3 LYS Z 101
PRO Z 102
SER Z 103
 G  A  95 ( 3.5A)
A  A  94 ( 3.9A)
A  A  94 ( 3.0A)
 0.50A 4k50I-5x8tZ:
undetectable		 4k50I-5x8tZ:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5x8t 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 ILE U 176
PHE U 136
ARG U 160
VAL U 162
ILE U 147
 None
None
C  A1420 ( 3.1A)
None
None
 1.13A 4rvdA-5x8tU:
undetectable		 4rvdA-5x8tU:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 5 ASN L   9
LEU L  19
HIS L   7
CYH L  21
 None
None
G  A1703 ( 4.1A)
None
 1.38A 5eu8A-5x8tL:
undetectable		 5eu8A-5x8tL:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5x8t 50S RIBOSOMAL
PROTEIN L31
(Spinacia
oleracea) 		4 / 8 GLU 0  71
GLY 0  75
THR 0  60
TYR 0  52
 None
 0.93A 5flcB-5x8t0:
undetectable		 5flcB-5x8t0:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5x8t 50S RIBOSOMAL
PROTEIN L31
(Spinacia
oleracea) 		4 / 8 GLU 0  71
GLY 0  75
THR 0  60
TYR 0  52
 None
 0.93A 5flcF-5x8t0:
undetectable		 5flcF-5x8t0:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5x8t PROTEIN L17
(Spinacia
oleracea) 		5 / 12 LYS O  56
VAL O  58
ILE O  62
LYS O  66
ILE O 123
 G  W  76 ( 4.0A)
None
None
None
None
 0.76A 5j2tC-5x8tO:
undetectable		 5j2tC-5x8tO:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5x8t 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
PROTEIN L29
(Spinacia
oleracea) 		4 / 8 LEU Z  92
PHE U 155
LEU U 134
ILE U 176
 None
 0.95A 5mzjA-5x8tZ:
3.0		 5mzjA-5x8tZ:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5x8t PROTEIN L27
(Spinacia
oleracea) 		4 / 8 GLN X  85
GLY X  83
ILE X  93
GLN X  96
 A  A 932 ( 2.6A)
G  A 866 ( 3.3A)
None
None
 0.99A 5vlmD-5x8tX:
undetectable		 5vlmD-5x8tX:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5x8t 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 10 ALA Q 130
GLY Q 176
THR Q 179
ILE Q 177
ALA Q 134
 None
 1.13A 5vyhA-5x8tQ:
undetectable		 5vyhA-5x8tQ:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5x8t 50S RIBOSOMAL
PROTEIN L14,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 ARG L  78
LYS L   1
ARG Q 182
 A  A1701 ( 4.7A)
A  A1701 ( 3.8A)
G  A2702 ( 3.1A)
 1.14A 6az3C-5x8tL:
undetectable
6az3L-5x8tL:
undetectable
6az3M-5x8tL:
undetectable		 6az3C-5x8tL:
21.85
6az3L-5x8tL:
15.57
6az3M-5x8tL:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5x8t PROTEIN L17
(Spinacia
oleracea) 		4 / 4 LYS O  50
LEU O  34
ALA O  51
LEU O  38
 A  A1298 ( 3.5A)
A  A1298 ( 3.8A)
None
None
 1.32A 6gnrA-5x8tO:
undetectable		 6gnrA-5x8tO:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5x8t PROTEIN L17
(Spinacia
oleracea) 		4 / 4 LYS O  50
LEU O  34
ALA O  51
LEU O  38
 A  A1298 ( 3.5A)
A  A1298 ( 3.8A)
None
None
 1.30A 6gnrB-5x8tO:
undetectable		 6gnrB-5x8tO:
20.74