SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 7 GLY A 221
HIS A 198
ASP A 192
LYS A   1
 None
 1.17A 1th6A-5x8zA:
undetectable		 1th6A-5x8zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 7 THR A  61
THR A  77
SER A  74
MET A  52
 None
 0.94A 1tv8A-5x8zA:
undetectable		 1tv8A-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 7 THR A  61
THR A  77
SER A  74
MET A  52
 None
 0.88A 1tv8B-5x8zA:
undetectable		 1tv8B-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 7 GLY A 221
HIS A 198
ASP A 192
LYS A   1
 None
 1.18A 2armA-5x8zA:
undetectable		 2armA-5x8zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 7 THR A  61
THR A  77
SER A  74
MET A  52
 None
 0.99A 2fb2B-5x8zA:
undetectable		 2fb2B-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 7 ASN A  79
LEU A  83
THR A  77
VAL A  85
 None
 1.17A 2uz2A-5x8zA:
undetectable		 2uz2A-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 8 LEU A 166
MET A  86
ALA A  87
GLN A 175
 None
 0.89A 3cldB-5x8zA:
undetectable		 3cldB-5x8zA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		3 / 3 THR A  77
SER A  63
PHE A 277
 None
 0.73A 3d4sA-5x8zA:
undetectable		 3d4sA-5x8zA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		3 / 3 MET A 318
MET A  15
PHE A  26
 None
 1.38A 3gn8A-5x8zA:
undetectable		 3gn8A-5x8zA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 5 LEU A 259
ALA A 257
MET A  15
THR A  17
 None
 1.39A 3vasB-5x8zA:
undetectable		 3vasB-5x8zA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		5 / 11 SER A  78
THR A  12
LEU A 283
ARG A  16
GLN A 280
 None
 1.24A 3zqeA-5x8zA:
undetectable
3zqeB-5x8zA:
undetectable		 3zqeA-5x8zA:
undetectable
3zqeB-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		3 / 3 ASN A 285
ASP A 287
ASN A 302
 None
 0.68A 4agaA-5x8zA:
undetectable		 4agaA-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		5 / 10 ARG A  16
LEU A  88
ASN A 191
HIS A  91
ALA A  18
 None
 1.20A 4ij8A-5x8zA:
0.0
4ij8B-5x8zA:
0.0		 4ij8A-5x8zA:
undetectable
4ij8B-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 4 ASN A 103
GLY A 134
ASP A 159
ASP A 132
 None
 1.31A 4n49A-5x8zA:
undetectable		 4n49A-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		4 / 6 TYR A  59
LYS A 307
GLY A  82
ASP A 161
 None
 1.16A 5emlA-5x8zA:
undetectable		 5emlA-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN
(Shewanella
loihica) 		5 / 12 VAL A 127
GLU A 126
LEU A  14
LEU A 283
THR A  12
 None
 1.19A 5hnwB-5x8zA:
undetectable		 5hnwB-5x8zA:
12.93