SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 7 VAL A 100
LEU A  61
LEU A 115
LEU A 111
 None
 0.87A 1cqpA-5x9gA:
undetectable
1cqpB-5x9gA:
undetectable		 1cqpA-5x9gA:
20.86
1cqpB-5x9gA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 6 LEU A  61
ALA A  70
LEU A  64
SER A  65
 None
 1.30A 1tyrA-5x9gA:
undetectable		 1tyrA-5x9gA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 10 ALA A  96
LEU A  81
LEU A  73
LEU A 111
ARG A 110
 None
 1.16A 2xn6A-5x9gA:
undetectable
2xn6B-5x9gA:
undetectable		 2xn6A-5x9gA:
20.95
2xn6B-5x9gA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 10 ALA A  96
LEU A  81
LEU A  73
LEU A 111
ARG A 110
 None
 1.08A 2xn7A-5x9gA:
undetectable
2xn7B-5x9gA:
undetectable		 2xn7A-5x9gA:
20.95
2xn7B-5x9gA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 7 ASP A 250
SER A  65
GLU A  68
ASP A  38
 None
 1.28A 3bc9A-5x9gA:
undetectable		 3bc9A-5x9gA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 7 ARG A 110
LEU A  97
ARG A  82
ILE A  84
 None
 1.07A 3ln1C-5x9gA:
undetectable		 3ln1C-5x9gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 5 ARG A 110
LEU A  97
ARG A  82
ILE A  84
 None
 1.09A 3ln1D-5x9gA:
undetectable		 3ln1D-5x9gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 5 ASP A  95
GLU A 131
GLY A 136
ASP A 247
 MG  A 303 (-2.2A)
None
MG  A 303 (-3.9A)
MG  A 302 (-2.7A)
 1.34A 3w9tD-5x9gA:
undetectable		 3w9tD-5x9gA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 8 HIS A  63
SER A  89
THR A 139
ASP A 250
 None
 1.20A 5t8sB-5x9gA:
undetectable		 5t8sB-5x9gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5x9g MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 8 ASP A 250
HIS A  29
GLU A  59
GLU A 166
 None
None
None
MG  A 302 ( 3.5A)
 1.31A 6mn4C-5x9gA:
undetectable		 6mn4C-5x9gA:
24.28