SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5x9j PRHC
(Penicillium
brasilianum) 		4 / 6 GLU A 126
THR A  56
TYR A  59
TYR A 104
 None
 1.20A 1qvuA-5x9jA:
undetectable		 1qvuA-5x9jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5x9j PRHC
(Penicillium
brasilianum) 		5 / 12 ILE A  20
ILE A  21
LEU A  32
LEU A 112
PHE A  72
 None
 1.14A 1xzxX-5x9jA:
undetectable		 1xzxX-5x9jA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5x9j PRHC
(Penicillium
brasilianum) 		4 / 6 ILE A  21
PHE A  60
ARG A  33
ILE A 124
 None
 1.13A 4zzcA-5x9jA:
undetectable
4zzcB-5x9jA:
undetectable		 4zzcA-5x9jA:
19.49
4zzcB-5x9jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5x9j PRHC
(Penicillium
brasilianum) 		4 / 6 ILE A  21
PHE A  60
ARG A  33
ILE A 124
 None
 1.18A 4zzcB-5x9jA:
undetectable
4zzcC-5x9jA:
undetectable		 4zzcB-5x9jA:
19.49
4zzcC-5x9jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5x9j PRHC
(Penicillium
brasilianum) 		3 / 3 TYR A 104
SER A  96
TRP A  63
 None
 0.91A 5n8jB-5x9jA:
2.1		 5n8jB-5x9jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5x9j PRHC
(Penicillium
brasilianum) 		3 / 3 TYR A 104
SER A  96
TRP A  63
 None
 0.90A 5n8jA-5x9jA:
1.8		 5n8jA-5x9jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5x9j PRHC
(Penicillium
brasilianum) 		3 / 3 TYR A 104
SER A  96
TRP A  63
 None
 0.96A 5n8jD-5x9jA:
2.1		 5n8jD-5x9jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5x9j PRHC
(Penicillium
brasilianum) 		5 / 12 LEU A 109
ASN A 108
ILE A  89
ALA A  14
ILE A 111
 None
 0.97A 5nm5B-5x9jA:
undetectable		 5nm5B-5x9jA:
15.51