SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 8 MET A  58
SER A  41
ALA A 106
ILE A 107
 None
 1.06A 1gm7A-5x9rA:
undetectable
1gm7B-5x9rA:
2.2		 1gm7A-5x9rA:
18.62
1gm7B-5x9rA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 9 GLY A 430
GLY A 183
GLY A 404
GLY A 406
ASP A 407
 None
None
FLC  A 501 (-3.6A)
None
None
 1.04A 1mxdA-5x9rA:
undetectable		 1mxdA-5x9rA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 11 GLY A 430
GLY A 183
GLY A 404
GLY A 406
ASP A 407
 None
None
FLC  A 501 (-3.6A)
None
None
 1.04A 1mxgA-5x9rA:
undetectable		 1mxgA-5x9rA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 5 ARG A 428
ASP A 112
ASN A 109
TYR A 300
 FLC  A 501 (-2.8A)
None
None
None
 1.21A 1nbiA-5x9rA:
undetectable		 1nbiA-5x9rA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 5 ARG A 428
ASP A 112
ASN A 109
TYR A 300
 FLC  A 501 (-2.8A)
None
None
None
 1.21A 1nbiB-5x9rA:
undetectable		 1nbiB-5x9rA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 4 ALA A 282
VAL A 285
ALA A 286
HIS A 299
 None
 1.21A 1q23F-5x9rA:
undetectable		 1q23F-5x9rA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 11 LEU A 408
ASP A 407
GLY A 403
ILE A 121
HIS A 299
 None
None
FLC  A 501 ( 3.8A)
None
None
 1.19A 1tmxA-5x9rA:
undetectable		 1tmxA-5x9rA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 5 LEU A 375
GLY A 234
PRO A 388
ALA A 378
 None
 0.80A 2aohA-5x9rA:
undetectable		 2aohA-5x9rA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 9 ALA A 395
ALA A 155
GLY A 372
GLY A 151
ILE A 152
 None
 1.22A 2v7bB-5x9rA:
undetectable		 2v7bB-5x9rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 GLY A 403
GLY A 189
GLY A 184
LEU A 216
ASN A 186
 FLC  A 501 ( 3.8A)
None
None
None
FLC  A 501 (-3.7A)
 1.07A 2zbpA-5x9rA:
undetectable		 2zbpA-5x9rA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 ILE A  98
GLU A 103
LEU A  38
ILE A  64
THR A 100
 None
 1.29A 2zzaA-5x9rA:
undetectable		 2zzaA-5x9rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 11 ILE A  98
GLU A 103
LEU A  38
ILE A  64
THR A 100
 None
 1.26A 2zzaB-5x9rA:
undetectable		 2zzaB-5x9rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		6 / 12 ILE A 433
GLY A 432
GLY A 431
ALA A 188
ALA A 302
VAL A 296
 None
 1.44A 3jb2A-5x9rA:
undetectable		 3jb2A-5x9rA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 PHE A  87
THR A 349
ALA A 122
ILE A 420
ALA A 423
 None
 1.14A 3nxuB-5x9rA:
undetectable		 3nxuB-5x9rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 10 ALA A 155
PHE A 158
GLY A 159
ILE A 162
PHE A 222
 None
 0.80A 3qpsA-5x9rA:
undetectable		 3qpsA-5x9rA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 8 GLY A 380
ILE A 157
SER A 156
GLY A 151
 None
 0.78A 5alcL-5x9rA:
undetectable		 5alcL-5x9rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 4 ILE A 437
GLY A 431
ILE A 152
LEU A 435
 None
 0.82A 5dzkl-5x9rA:
undetectable
5dzkz-5x9rA:
undetectable		 5dzkl-5x9rA:
19.86
5dzkz-5x9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 ILE A 321
GLU A 267
GLY A 324
CYH A 278
THR A 277
 None
 1.45A 5fhzD-5x9rA:
undetectable		 5fhzD-5x9rA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		4 / 8 ASP A 407
GLY A 185
LEU A 216
ASN A 220
 None
FLC  A 501 (-3.5A)
None
None
 0.76A 5hwaA-5x9rA:
undetectable		 5hwaA-5x9rA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 VAL A 410
ASP A 407
GLU A 409
GLY A 185
LEU A 216
 None
None
None
FLC  A 501 (-3.5A)
None
 1.50A 5m50B-5x9rA:
undetectable		 5m50B-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 VAL A 178
ALA A 155
SER A 156
THR A 394
GLY A 431
 None
 1.27A 5m54E-5x9rA:
undetectable		 5m54E-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 VAL A 178
ALA A 155
SER A 156
THR A 394
GLY A 431
 None
 1.19A 5m5cB-5x9rA:
undetectable		 5m5cB-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 10 VAL A 178
ALA A 155
SER A 156
THR A 394
GLY A 431
 None
 1.19A 5m5cE-5x9rA:
undetectable		 5m5cE-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 ILE A  86
GLY A  66
PHE A  75
ALA A  90
MET A 341
 None
 1.20A 5n0wA-5x9rA:
undetectable		 5n0wA-5x9rA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		5 / 12 ILE A  86
GLY A  66
PHE A  75
ALA A  90
MET A 341
 None
 1.18A 5n0xB-5x9rA:
undetectable		 5n0xB-5x9rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		3 / 3 THR A 349
THR A 217
ARG A 402
 None
None
FLC  A 501 (-3.7A)
 1.04A 5wm2A-5x9rA:
undetectable		 5wm2A-5x9rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5x9r CITRATE-SODIUM
SYMPORTER
(Klebsiella
pneumoniae) 		3 / 3 TYR A 209
PRO A 192
LEU A 193
 None
 0.91A 6beoA-5x9rA:
undetectable		 6beoA-5x9rA:
2.76