SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 12 PRO A 426
PHE A 394
GLN A  81
ALA A 488
SER A 489
 None
 1.37A 1fm4A-5x9uA:
undetectable		 1fm4A-5x9uA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE A 197
THR A 305
VAL A 218
LEU A 269
ILE A 202
 None
 1.28A 1kqwA-5x9uA:
undetectable		 1kqwA-5x9uA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		4 / 7 THR A  91
VAL A  85
GLY A  86
ASP A 476
 ADP  A 601 (-3.9A)
None
None
ADP  A 601 (-2.6A)
 0.86A 2a1mA-5x9uA:
undetectable		 2a1mA-5x9uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		4 / 8 THR A  91
VAL A  85
GLY A  86
ASP A 476
 ADP  A 601 (-3.9A)
None
None
ADP  A 601 (-2.6A)
 0.83A 2a1oA-5x9uA:
undetectable		 2a1oA-5x9uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 12 ALA A  92
ALA A 492
LEU A  99
LEU A 124
ILE A 493
 None
 1.16A 2h77A-5x9uA:
undetectable		 2h77A-5x9uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		4 / 8 ALA A 371
ALA A 375
GLY A  86
ALA A 153
 None
 0.92A 2vh3B-5x9uA:
undetectable		 2vh3B-5x9uA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		4 / 8 ALA A 371
ALA A 374
ILE A 356
THR A 194
 None
 0.76A 3dtuC-5x9uA:
undetectable
3dtuD-5x9uA:
undetectable		 3dtuC-5x9uA:
21.88
3dtuD-5x9uA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		3 / 3 ASN A 125
HIS A 126
VAL A 401
 None
 0.67A 3elzB-5x9uA:
undetectable		 3elzB-5x9uA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 10 GLY A 345
GLY A 346
THR A 305
GLU A 344
ILE A 343
 None
 1.29A 3fw1A-5x9uA:
undetectable		 3fw1A-5x9uA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		4 / 6 LEU A 130
ILE A 131
LEU A 397
TYR A 396
 None
 0.86A 4w5nA-5x9uA:
undetectable		 4w5nA-5x9uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 11 LEU A 326
LEU A 221
LEU A 322
GLU A 262
LEU A 260
 None
 1.17A 4wg0B-5x9uA:
undetectable
4wg0C-5x9uA:
undetectable
4wg0D-5x9uA:
undetectable		 4wg0B-5x9uA:
3.48
4wg0C-5x9uA:
3.48
4wg0D-5x9uA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 11 LEU A 326
LEU A 221
LEU A 322
GLU A 262
LEU A 260
 None
 1.20A 4wg0H-5x9uA:
undetectable
4wg0I-5x9uA:
undetectable
4wg0J-5x9uA:
undetectable		 4wg0H-5x9uA:
3.48
4wg0I-5x9uA:
3.48
4wg0J-5x9uA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLU A 262
LEU A 260
LEU A 322
LEU A 326
LEU A 221
 None
 1.15A 4wg0K-5x9uA:
undetectable
4wg0L-5x9uA:
undetectable
4wg0M-5x9uA:
undetectable		 4wg0K-5x9uA:
3.48
4wg0L-5x9uA:
3.48
4wg0M-5x9uA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		4 / 7 ALA A 169
GLY A 199
THR A 331
GLU A 344
 None
 1.03A 5bs8A-5x9uA:
undetectable
5bs8B-5x9uA:
undetectable
5bs8C-5x9uA:
undetectable		 5bs8A-5x9uA:
22.69
5bs8B-5x9uA:
20.87
5bs8C-5x9uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		3 / 3 VAL A 429
GLU A 421
GLU A 102
 None
 0.79A 5jsdB-5x9uA:
undetectable
5jsdC-5x9uA:
undetectable		 5jsdB-5x9uA:
21.88
5jsdC-5x9uA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU A  17
GLY A 103
ALA A  21
GLU A 421
PHE A 419
 None
 1.25A 5x6yA-5x9uA:
undetectable		 5x6yA-5x9uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 12 VAL A 474
GLY A  39
MET A 430
THR A  89
GLY A  88
 ADP  A 601 (-4.7A)
None
ADP  A 601 (-4.1A)
ADP  A 601 (-4.5A)
ADP  A 601 (-3.2A)
 1.04A 6brdC-5x9uA:
undetectable		 6brdC-5x9uA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5x9u THERMOSOME, ALPHA
SUBUNIT
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU A 223
ILE A 268
LEU A 215
LEU A 326
GLY A 327
 None
 1.10A 6qxsD-5x9uA:
undetectable		 6qxsD-5x9uA:
21.15