SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 8 GLU C 115
ARG C 127
ARG C 104
GLU C 138
 None
 1.01A 1cmaA-5x9yC:
undetectable
1cmaB-5x9yC:
undetectable		 1cmaA-5x9yC:
16.33
1cmaB-5x9yC:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 12 ASN C  26
SER C  27
ASP C  29
ASP C  51
THR C 135
 None
 0.74A 1s14A-5x9yC:
16.6		 1s14A-5x9yC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 7 GLY C  55
PHE C 107
PRO C  58
ASP C  60
 None
 0.94A 2aouB-5x9yC:
undetectable		 2aouB-5x9yC:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 12 VAL C  40
LEU C  46
ILE C  13
SER C  96
LEU C  23
 None
 1.18A 3cjtK-5x9yC:
undetectable		 3cjtK-5x9yC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 8 PHE C 108
VAL C 133
ASN C  52
GLY C  53
 None
 0.86A 3hjoB-5x9yC:
undetectable		 3hjoB-5x9yC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 7 PHE C 108
VAL C 133
ASN C  52
GLY C  53
 None
 0.88A 3kmoB-5x9yC:
undetectable		 3kmoB-5x9yC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 12 ASN C  26
SER C  27
ASP C  29
ASP C  51
THR C 135
 None
 0.73A 3lpsA-5x9yC:
16.7		 3lpsA-5x9yC:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 7 GLU C 249
PHE C 250
TYR C 257
VAL C 224
 None
 1.07A 4a97A-5x9yC:
undetectable		 4a97A-5x9yC:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 5 THR C 219
ILE C 218
GLU C 216
PHE C 270
 None
 1.32A 4ac9C-5x9yC:
undetectable		 4ac9C-5x9yC:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		4 / 5 THR C 219
ILE C 218
GLU C 216
PHE C 270
 None
 1.35A 4acbC-5x9yC:
undetectable		 4acbC-5x9yC:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 12 ASP C  18
PHE C 182
ILE C  39
VAL C 163
LEU C 164
 None
 1.15A 4fr0A-5x9yC:
undetectable		 4fr0A-5x9yC:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 11 ASN C  26
SER C  27
ASP C  29
ASP C  51
THR C 135
 None
 0.72A 4urnA-5x9yC:
15.2		 4urnA-5x9yC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 11 ASN C  26
SER C  27
ASP C  29
ASP C  51
THR C 135
 None
 0.68A 4urnB-5x9yC:
15.9		 4urnB-5x9yC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 11 ASN C  26
SER C  27
ASP C  29
ASP C  51
THR C 135
 None
 0.71A 4urnC-5x9yC:
15.5		 4urnC-5x9yC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 12 ASN C  26
SER C  27
ASP C  51
ILE C  56
SER C  94
 None
 1.20A 4uroB-5x9yC:
15.9		 4uroB-5x9yC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		6 / 12 ASN C  26
SER C  27
ASP C  51
ILE C  56
SER C  94
THR C 135
 None
 1.18A 4uroD-5x9yC:
15.9		 4uroD-5x9yC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 5x9y DNA MISMATCH REPAIR
PROTEIN MUTL
(Aquifex
aeolicus) 		5 / 12 ARG C 104
GLU C 115
ARG C 127
GLU C 117
ARG C 140
 None
 1.28A 5l17A-5x9yC:
undetectable		 5l17A-5x9yC:
20.79