SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xa1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 GLY A 205
GLU A  42
ASN A 203
 None
 0.62A 1zq9A-5xa1A:
undetectable		 1zq9A-5xa1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 5 VAL A 177
VAL A 176
ARG A 170
LYS A 219
 None
 1.13A 3rv5A-5xa1A:
undetectable
3rv5B-5xa1A:
undetectable		 3rv5A-5xa1A:
5.16
3rv5B-5xa1A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 10 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.35A 4eilB-5xa1A:
undetectable		 4eilB-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 10 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.31A 4eilD-5xa1A:
undetectable		 4eilD-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 ARG A 148
TYR A  66
ASN A 188
 None
 0.76A 4ffwB-5xa1A:
undetectable		 4ffwB-5xa1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 11 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.28A 4kyaA-5xa1A:
undetectable		 4kyaA-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 12 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.34A 4kyaB-5xa1A:
undetectable		 4kyaB-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 10 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.26A 4kyaC-5xa1A:
undetectable		 4kyaC-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 12 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.34A 4kyaD-5xa1A:
undetectable		 4kyaD-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 11 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.28A 4kyaE-5xa1A:
undetectable		 4kyaE-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 12 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.35A 4kyaF-5xa1A:
undetectable		 4kyaF-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 11 VAL A 435
ALA A 438
ASP A 442
SER A 277
VAL A 239
 None
 1.43A 4kyaG-5xa1A:
undetectable		 4kyaG-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 11 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.25A 4kyaG-5xa1A:
undetectable		 4kyaG-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 12 VAL A 435
ALA A 438
ASP A 442
SER A 278
VAL A 239
 None
 1.33A 4kyaH-5xa1A:
undetectable		 4kyaH-5xa1A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 8 ASP A  55
VAL A  33
ASP A 444
ASP A 448
 None
 1.04A 4xqgA-5xa1A:
undetectable		 4xqgA-5xa1A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		4 / 8 ASP A  55
VAL A  33
ASP A 444
ASP A 448
 None
 1.05A 4xqgB-5xa1A:
undetectable		 4xqgB-5xa1A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		5 / 12 ALA A  75
ASP A  97
LYS A 100
PHE A  72
TYR A  66
 None
 1.34A 5hfjA-5xa1A:
undetectable		 5hfjA-5xa1A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5xa1 INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1
(Mus
musculus) 		3 / 3 GLY A 158
ASN A 156
ARG A 137
 None
 0.68A 5w7bD-5xa1A:
undetectable		 5w7bD-5xa1A:
4.25