SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xa2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLU A  56
ILE A  11
ALA A 148
ARG A  86
GLU A   9
 None
 1.31A 1ki7B-5xa2A:
undetectable		 1ki7B-5xa2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLU A 239
GLY A 175
VAL A 237
ALA A 272
PHE A 232
 None
 1.28A 1nw3A-5xa2A:
2.9		 1nw3A-5xa2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 MET A  98
ASN A  74
GLN A 143
 None
LLP  A  44 ( 3.8A)
LLP  A  44 ( 4.8A)
 0.71A 1xoqB-5xa2A:
undetectable		 1xoqB-5xa2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.16A 2dcfA-5xa2A:
undetectable		 2dcfA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.14A 2zmaA-5xa2A:
undetectable		 2zmaA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.17A 3a65A-5xa2A:
undetectable		 3a65A-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3a66A-5xa2A:
0.0		 3a66A-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A 278
LEU A 275
SER A  27
GLY A 285
SER A  28
 None
 1.06A 3g2oB-5xa2A:
3.2		 3g2oB-5xa2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 158
ILE A  47
GLY A 180
ILE A 182
PRO A 293
 None
LLP  A  44 ( 4.1A)
LLP  A  44 ( 3.9A)
None
LLP  A  44 ( 4.1A)
 0.93A 3oxcB-5xa2A:
undetectable		 3oxcB-5xa2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 TYR A  88
LEU A  90
ALA A  49
THR A  71
PRO A 141
 None
 1.44A 3qelA-5xa2A:
2.4
3qelB-5xa2A:
undetectable		 3qelA-5xa2A:
20.37
3qelB-5xa2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		4 / 5 VAL A 176
GLU A  69
LYS A 145
PHE A 232
 LLP  A  44 ( 4.0A)
None
None
None
 1.44A 3rv5C-5xa2A:
undetectable
3rv5D-5xa2A:
undetectable		 3rv5C-5xa2A:
16.56
3rv5D-5xa2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ASP A 238
GLY A 184
ALA A 186
PHE A 172
ALA A 174
 None
 0.92A 3sudA-5xa2A:
undetectable		 3sudA-5xa2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ASP A 238
GLY A 184
ALA A 186
PHE A 172
ALA A 174
 None
 0.96A 3sudD-5xa2A:
undetectable		 3sudD-5xa2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ASP A 238
GLY A 184
ALA A 186
PHE A 172
ALA A 174
 None
 1.00A 3sugA-5xa2A:
undetectable		 3sugA-5xa2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 158
ILE A  47
GLY A 180
ILE A 182
PRO A 293
 None
LLP  A  44 ( 4.1A)
LLP  A  44 ( 3.9A)
None
LLP  A  44 ( 4.1A)
 1.03A 3tkgB-5xa2A:
undetectable		 3tkgB-5xa2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		4 / 7 ASN A 146
ALA A 148
ARG A  86
ALA A  55
 None
 1.07A 3twpA-5xa2A:
undetectable		 3twpA-5xa2A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3vwpA-5xa2A:
undetectable		 3vwpA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3vwqA-5xa2A:
undetectable		 3vwqA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.14A 3vwrA-5xa2A:
undetectable		 3vwrA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		4 / 4 GLU A 160
GLY A 158
HIS A 153
ARG A  46
 None
 1.17A 4r82A-5xa2A:
undetectable
4r82B-5xa2A:
undetectable		 4r82A-5xa2A:
21.54
4r82B-5xa2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		4 / 7 LEU A  26
SER A  28
ILE A 288
VAL A 171
 None
 1.01A 4tvtA-5xa2A:
undetectable		 4tvtA-5xa2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 LEU A 255
MET A 271
ALA A  32
VAL A  17
ILE A  19
 None
 1.11A 4x20D-5xa2A:
undetectable		 4x20D-5xa2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 ALA A 248
GLY A 264
VAL A 202
LEU A 241
THR A 290
 None
 1.13A 4zmeA-5xa2A:
undetectable		 4zmeA-5xa2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 179
GLY A 226
GLY A 224
GLY A 177
GLU A 203
 LLP  A  44 ( 3.1A)
None
None
LLP  A  44 ( 3.5A)
None
 0.94A 5njvC-5xa2A:
undetectable		 5njvC-5xa2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 179
GLY A 226
GLY A 224
GLY A 177
GLU A 203
 LLP  A  44 ( 3.1A)
None
None
LLP  A  44 ( 3.5A)
None
 0.97A 5vimA-5xa2A:
undetectable		 5vimA-5xa2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 THR A  14
GLU A 160
HIS A 153
 None
 0.89A 5xioA-5xa2A:
undetectable		 5xioA-5xa2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 THR A  14
GLU A 160
HIS A 153
 None
 0.90A 5xiqB-5xa2A:
undetectable		 5xiqB-5xa2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 THR A  14
GLU A 160
HIS A 153
 None
 0.91A 5xiqD-5xa2A:
undetectable		 5xiqD-5xa2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 GLU A   9
GLY A  48
ALA A  50
ILE A 152
ARG A  46
 None
LLP  A  44 ( 3.7A)
None
None
None
 0.90A 5yk2A-5xa2A:
undetectable		 5yk2A-5xa2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 PHE A 144
GLY A 224
GLY A 226
ALA A 215
ILE A 220
 None
 1.05A 6b3aA-5xa2A:
4.8		 6b3aA-5xa2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 PHE A 144
GLY A 224
GLY A 226
ALA A 215
ILE A 220
 None
 1.07A 6b3bA-5xa2A:
3.9		 6b3bA-5xa2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		4 / 6 ILE A 182
LEU A 210
VAL A 237
ARG A 234
 None
 0.97A 6f6jA-5xa2A:
undetectable		 6f6jA-5xa2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 THR A 290
ALA A 274
LYS A 276
 None
 0.68A 6fgcA-5xa2A:
undetectable		 6fgcA-5xa2A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 THR A 290
ALA A 274
LYS A 276
 None
 0.68A 6fgdA-5xa2A:
undetectable		 6fgdA-5xa2A:
24.59