SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 6 LEU A  22
ILE A 135
GLU A  15
ASP A  14
 None
 1.02A 1ditH-5xa5A:
undetectable
1ditP-5xa5A:
undetectable		 1ditH-5xa5A:
20.13
1ditP-5xa5A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2
(Caenorhabditis
elegans) 		4 / 6 LEU A 193
VAL A 130
VAL B  49
ILE A 135
 None
 0.91A 2hyyB-5xa5A:
undetectable		 2hyyB-5xa5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 PRO A  73
ILE A 140
LEU A 136
ILE A  69
 None
 0.98A 3p50A-5xa5A:
8.0		 3p50A-5xa5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 PRO A  73
ILE A 140
LEU A 136
ILE A  69
 None
 0.98A 3p50B-5xa5A:
8.1		 3p50B-5xa5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 PRO A  73
ILE A 140
LEU A 136
ILE A  69
 None
 0.97A 3p50C-5xa5A:
8.1		 3p50C-5xa5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 PRO A  73
ILE A 140
LEU A 136
ILE A  69
 None
 0.95A 3p50D-5xa5A:
8.1		 3p50D-5xa5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 PRO A  73
ILE A 140
LEU A 136
ILE A  69
 None
 0.97A 3p50E-5xa5A:
8.0		 3p50E-5xa5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 10 ALA A 119
GLY A 123
LEU A 126
ASN A 125
ILE A 100
 None
 1.18A 3wdmB-5xa5A:
undetectable		 3wdmB-5xa5A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 126
GLY A 123
LEU B  67
VAL A  51
ILE A 118
 None
 1.35A 4okbA-5xa5A:
undetectable		 4okbA-5xa5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2
(Caenorhabditis
elegans) 		4 / 8 THR B  56
SER B  47
ASP A 192
SER A  18
 None
 0.88A 5l5fY-5xa5B:
undetectable
5l5fZ-5xa5B:
undetectable		 5l5fY-5xa5B:
12.82
5l5fZ-5xa5B:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 THR A 220
ALA A 240
THR A 239
ALA A 156
LEU A 250
 None
 1.05A 5lf7H-5xa5A:
undetectable
5lf7I-5xa5A:
undetectable		 5lf7H-5xa5A:
22.49
5lf7I-5xa5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		5 / 11 THR A 220
ALA A 240
THR A 239
ALA A 156
LEU A 250
 None
 1.01A 5lf7V-5xa5A:
undetectable
5lf7W-5xa5A:
undetectable		 5lf7V-5xa5A:
22.49
5lf7W-5xa5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 12 ARG A 188
ASP A 141
THR B  46
LEU A  89
PHE A 133
 None
 1.32A 5ybbB-5xa5A:
undetectable		 5ybbB-5xa5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 4 ALA A 205
ALA A 208
ALA A 246
ALA A 249
 None
 0.81A 6gtqA-5xa5A:
undetectable
6gtqB-5xa5A:
undetectable		 6gtqA-5xa5A:
20.57
6gtqB-5xa5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 4 ALA A 246
ALA A 249
ALA A 205
ALA A 208
 None
 0.81A 6gtqA-5xa5A:
undetectable
6gtqB-5xa5A:
undetectable		 6gtqA-5xa5A:
20.57
6gtqB-5xa5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 6 ARG A 153
ALA A 246
THR A 212
ALA A 156
 None
 1.12A 6ma6A-5xa5A:
2.9		 6ma6A-5xa5A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
(Caenorhabditis
elegans) 		4 / 7 ARG A 153
HIS A 157
ASP A 150
GLU A 251
 None
 1.34A 6mn4F-5xa5A:
undetectable		 6mn4F-5xa5A:
23.68