SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 11 HIS F 308
LEU F 307
HIS F  54
PHE F  49
GLY F  50
None
1.30A 1cmaA-5xagF:
undetectable
1cmaB-5xagF:
undetectable
1cmaA-5xagF:
undetectable
1cmaB-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 12 HIS F  54
PHE F  49
GLY F  50
HIS F 308
LEU F 307
None
1.28A 1mj2C-5xagF:
undetectable
1mj2D-5xagF:
undetectable
1mj2C-5xagF:
undetectable
1mj2D-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 9 HIS F 308
LEU F 307
HIS F  54
PHE F  49
GLY F  50
None
1.21A 1mjlA-5xagF:
undetectable
1mjlB-5xagF:
undetectable
1mjlA-5xagF:
undetectable
1mjlB-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 12 HIS F  54
PHE F  49
GLY F  50
HIS F 308
LEU F 307
None
1.29A 1mjoC-5xagF:
undetectable
1mjoD-5xagF:
undetectable
1mjoC-5xagF:
undetectable
1mjoD-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 11 HIS F 308
LEU F 307
HIS F  54
PHE F  49
GLY F  50
None
1.31A 1mjqA-5xagF:
undetectable
1mjqB-5xagF:
undetectable
1mjqA-5xagF:
undetectable
1mjqB-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 5 LYS F 184
PHE F 319
LEU F 186
LEU F  87
None
None
ACP  F 402 (-4.0A)
None
1.21A 1skxA-5xagF:
undetectable
1skxA-5xagF:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.78A 1v54N-5xagF:
undetectable
1v54W-5xagF:
undetectable
1v54N-5xagF:
undetectable
1v54W-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 10 LEU F  21
ALA F  23
ALA F 344
LEU F 346
GLN F 348
None
1.05A 1xp0A-5xagF:
undetectable
1xp0A-5xagF:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.77A 2dyrN-5xagF:
undetectable
2dyrW-5xagF:
undetectable
2dyrN-5xagF:
undetectable
2dyrW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.78A 2eijN-5xagF:
undetectable
2eijW-5xagF:
undetectable
2eijN-5xagF:
undetectable
2eijW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.79A 2eikN-5xagF:
undetectable
2eikW-5xagF:
undetectable
2eikN-5xagF:
undetectable
2eikW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.77A 2eilN-5xagF:
undetectable
2eilW-5xagF:
undetectable
2eilN-5xagF:
undetectable
2eilW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 12 ALA F 339
PHE F 267
ARG F 202
ILE F 201
ASP F 200
None
None
None
None
MG  F 401 (-3.8A)
1.29A 2v95A-5xagF:
undetectable
2v95A-5xagF:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.79A 3ablA-5xagF:
undetectable
3ablJ-5xagF:
undetectable
3ablA-5xagF:
undetectable
3ablJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.81A 3ablN-5xagF:
undetectable
3ablW-5xagF:
undetectable
3ablN-5xagF:
undetectable
3ablW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.77A 3ag3N-5xagF:
undetectable
3ag3W-5xagF:
undetectable
3ag3N-5xagF:
undetectable
3ag3W-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.78A 3asnN-5xagF:
undetectable
3asnW-5xagF:
undetectable
3asnN-5xagF:
undetectable
3asnW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 5 TYR F   2
THR F   3
PHE F   4
LEU F  61
None
0.76A 3qelC-5xagF:
3.0
3qelC-5xagF:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 5 ILE F 374
HIS F 209
TYR F  14
VAL F  17
None
1.26A 4s0vA-5xagF:
undetectable
4s0vA-5xagF:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 5 GLY F 259
TYR F 256
SER F 225
GLU F 258
None
1.22A 4xueA-5xagF:
undetectable
4xueA-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.77A 5b1bA-5xagF:
undetectable
5b1bJ-5xagF:
undetectable
5b1bA-5xagF:
undetectable
5b1bJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 TYR F  14
TYR F  64
GLY F 334
LEU F 314
None
1.20A 5bphB-5xagF:
12.7
5bphB-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
5 / 12 LEU F 295
SER F  76
GLU F 331
ARG F  73
GLY F 334
None
None
ACP  F 402 (-3.5A)
None
None
1.30A 5il1A-5xagF:
undetectable
5il1A-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 6 PHE F 315
VAL F 207
TYR F 211
ILE F 302
None
1.30A 5iwuA-5xagF:
undetectable
5iwuA-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.79A 5iy5A-5xagF:
undetectable
5iy5J-5xagF:
undetectable
5iy5A-5xagF:
undetectable
5iy5J-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.77A 5xdqA-5xagF:
undetectable
5xdqJ-5xagF:
undetectable
5xdqA-5xagF:
undetectable
5xdqJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.80A 5xdxN-5xagF:
undetectable
5xdxW-5xagF:
undetectable
5xdxN-5xagF:
undetectable
5xdxW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.78A 5zcoA-5xagF:
undetectable
5zcoJ-5xagF:
undetectable
5zcoA-5xagF:
undetectable
5zcoJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 8 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.81A 5zcqN-5xagF:
undetectable
5zcqW-5xagF:
undetectable
5zcqN-5xagF:
undetectable
5zcqW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.79A 6nmfA-5xagF:
undetectable
6nmfJ-5xagF:
undetectable
6nmfA-5xagF:
undetectable
6nmfJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 7 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.75A 6nmpA-5xagF:
undetectable
6nmpJ-5xagF:
undetectable
6nmpA-5xagF:
undetectable
6nmpJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5xag TUBULIN TYROSINE
LIGASE

(Gallus
gallus)
4 / 5 ILE F 201
LEU F 221
THR F 278
LEU F 271
None
0.80A 6nmpN-5xagF:
undetectable
6nmpW-5xagF:
undetectable
6nmpN-5xagF:
undetectable
6nmpW-5xagF:
undetectable