SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 5 GLY A 592
LEU A 595
THR A 596
VAL A 587
 None
 1.12A 1ekjF-5xapA:
undetectable
1ekjG-5xapA:
undetectable		 1ekjF-5xapA:
16.22
1ekjG-5xapA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 8 VAL A 614
LEU A 664
SER A 741
VAL A 745
 None
 1.12A 1jtvA-5xapA:
undetectable		 1jtvA-5xapA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 9 LEU A 712
LEU A 428
VAL A 357
GLY A 355
ALA A 354
 None
 1.28A 1pxxB-5xapA:
undetectable		 1pxxB-5xapA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 6 ILE A 628
VAL A 402
ILE A 369
ASP A 666
 None
 0.82A 1uwhA-5xapA:
undetectable		 1uwhA-5xapA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 7 THR A 555
VAL A 501
GLY A 500
THR A 649
 None
 0.80A 2a1mA-5xapA:
undetectable		 2a1mA-5xapA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 8 THR A 555
VAL A 501
GLY A 500
THR A 649
 None
 0.72A 2a1mB-5xapA:
undetectable		 2a1mB-5xapA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 9 GLY A 536
SER A 538
ILE A 541
VAL A 526
ILE A 569
 None
 1.28A 2nnhB-5xapA:
undetectable		 2nnhB-5xapA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 4 SER A 438
GLY A 329
HIS A 406
ASP A 666
 None
 1.14A 2oxtC-5xapA:
undetectable		 2oxtC-5xapA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 11 ALA A 693
THR A 697
ILE A 669
ILE A 674
ALA A 746
 None
 1.15A 2qhfA-5xapA:
undetectable		 2qhfA-5xapA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 ARG A 673
GLU A 676
SER A 626
 None
 0.88A 2xctD-5xapA:
undetectable		 2xctD-5xapA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 PHE A 468
ASN A 695
PHE A 470
 OLC  A 803 (-3.9A)
None
OLC  A 803 ( 4.2A)
 1.01A 2zbuD-5xapA:
undetectable		 2zbuD-5xapA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 PHE A  69
LEU A 338
GLY A 343
GLY A 339
ALA A 346
 None
None
OLC  A 806 (-3.9A)
None
None
 1.14A 3dh0B-5xapA:
undetectable		 3dh0B-5xapA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 9 ASP A 236
VAL A 233
GLY A 181
VAL A 241
ILE A 238
 None
 1.02A 3ekvB-5xapA:
undetectable		 3ekvB-5xapA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 GLY A 361
ALA A 362
ASP A 365
VAL A 432
THR A 427
 None
 0.92A 3el5B-5xapA:
undetectable		 3el5B-5xapA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 ILE A 694
SER A 667
SER A 671
 None
 0.64A 3iltH-5xapA:
undetectable		 3iltH-5xapA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 LEU A 348
LEU A 723
ILE A 296
GLY A 299
ALA A 300
 None
None
OLC  A 807 (-4.4A)
OLC  A 807 ( 4.5A)
OLC  A 807 ( 3.8A)
 0.78A 3n8zB-5xapA:
undetectable		 3n8zB-5xapA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 GLY A  79
GLY A 131
LEU A  72
ASP A 138
GLY A 288
 None
 0.86A 3sglA-5xapA:
undetectable		 3sglA-5xapA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 7 GLY A 355
THR A 359
ILE A 337
LEU A 341
 None
None
OLC  A 807 (-4.5A)
None
 0.88A 4ejjD-5xapA:
undetectable		 4ejjD-5xapA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 5 ALA A 459
ILE A 374
LEU A 378
LYS A 375
 None
 1.12A 4g19A-5xapA:
1.6		 4g19A-5xapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 5 THR A 596
GLY A 592
VAL A 587
PRO A 505
 None
 1.15A 4grkA-5xapA:
undetectable		 4grkA-5xapA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 4 VAL A 501
THR A 586
GLU A 585
GLU A 284
 None
 1.17A 4l78A-5xapA:
undetectable		 4l78A-5xapA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 5 PRO A 547
GLY A 720
ASP A 514
ASP A 544
 None
 0.81A 4n48B-5xapA:
undetectable		 4n48B-5xapA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 9 GLY A 361
ALA A 362
ASP A 365
VAL A 432
THR A 427
 None
 1.11A 4njtD-5xapA:
undetectable		 4njtD-5xapA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 PHE A  69
THR A 359
LEU A 348
 None
 0.61A 4qztA-5xapA:
undetectable		 4qztA-5xapA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 ALA A 443
GLY A 366
ALA A 387
GLY A 391
TYR A 392
 None
 1.29A 4r29A-5xapA:
0.3		 4r29A-5xapA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 ALA A 443
GLY A 366
ALA A 387
GLY A 391
TYR A 392
 None
 1.26A 4r29B-5xapA:
undetectable		 4r29B-5xapA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 ALA A 443
GLY A 366
ALA A 387
GLY A 391
TYR A 392
 None
 1.23A 4r29C-5xapA:
undetectable		 4r29C-5xapA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 ARG A 700
GLN A 696
GLU A 376
 None
 0.87A 4tvtA-5xapA:
undetectable		 4tvtA-5xapA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 4 GLY A 299
VAL A 357
PHE A 311
ILE A 307
 OLC  A 807 ( 4.5A)
None
None
None
 1.10A 4xv2B-5xapA:
undetectable		 4xv2B-5xapA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 5 PHE A 648
ASP A 502
PHE A 503
VAL A 653
 None
 1.01A 5a1rA-5xapA:
1.4		 5a1rA-5xapA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 GLY A 292
GLY A 288
THR A 510
ILE A 296
LEU A  76
 None
None
None
OLC  A 807 (-4.4A)
None
 1.16A 5bw4A-5xapA:
undetectable		 5bw4A-5xapA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 THR A 211
ASP A 212
ALA A 213
 None
 0.00A 5g5gB-5xapA:
undetectable		 5g5gB-5xapA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 8 LEU A  76
ILE A 430
THR A 427
MET A  70
 None
 1.00A 5ljbA-5xapA:
undetectable		 5ljbA-5xapA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 7 LEU A  76
ILE A 430
THR A 427
MET A  70
 None
 0.99A 5ljcA-5xapA:
undetectable		 5ljcA-5xapA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 6 PHE A 718
LEU A 716
SER A 298
GLY A 720
 None
 1.02A 5o4yF-5xapA:
undetectable		 5o4yF-5xapA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 7 PHE A 218
ARG A 247
ALA A 185
GLN A 246
 None
 1.10A 6b89A-5xapA:
undetectable		 6b89A-5xapA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 THR A 586
VAL A 556
THR A 281
VAL A 526
GLY A 570
 None
 1.36A 6gngB-5xapA:
undetectable		 6gngB-5xapA:
23.16