SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 10 VAL A 292
VAL A 215
GLY A 293
LEU A 399
TYR A 264
 None
 1.29A 1fkoA-5xavA:
undetectable		 1fkoA-5xavA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 11 LEU A 246
ALA A 549
GLY A 178
ILE A 177
VAL A 234
 None
 0.98A 1hxwB-5xavA:
undetectable		 1hxwB-5xavA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		4 / 7 ASN A 415
HIS A 324
PHE A 411
ILE A 432
 None
 1.46A 1tdnA-5xavA:
undetectable		 1tdnA-5xavA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 12 PHE A 214
LEU A 288
VAL A 292
GLY A 293
GLY A 289
 None
 1.26A 3dh0A-5xavA:
2.2		 3dh0A-5xavA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 10 ILE A 430
MET A 285
PHE A 312
LEU A 297
ALA A 315
 None
 1.25A 3lw5B-5xavA:
undetectable		 3lw5B-5xavA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 12 LEU A 338
ALA A 340
MET A 346
ILE A 352
HIS A 404
 None
 1.29A 3olsB-5xavA:
undetectable		 3olsB-5xavA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		4 / 5 ILE A 279
GLN A 199
ILE A 198
GLU A 196
 None
 0.79A 4a99D-5xavA:
undetectable		 4a99D-5xavA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 12 PHE A 270
GLU A 266
TRP A 249
PHE A 312
GLY A 293
 None
 1.34A 4hvcA-5xavA:
2.2		 4hvcA-5xavA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 12 PHE A 270
GLU A 266
TRP A 249
PHE A 312
GLY A 293
 None
 1.35A 4hvcB-5xavA:
undetectable		 4hvcB-5xavA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 11 LEU A 288
ALA A 287
LEU A 297
ILE A 195
GLY A 268
 None
 1.19A 4pxmB-5xavA:
undetectable		 4pxmB-5xavA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		4 / 7 PHE A 442
GLY A 480
GLY A 476
HIS A 477
 None
 0.90A 5n9xA-5xavA:
3.2		 5n9xA-5xavA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		5 / 12 ALA A 549
GLY A 551
ASN A 192
GLU A 193
GLU A 255
 None
 1.20A 5nwuA-5xavA:
undetectable		 5nwuA-5xavA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		4 / 5 ALA A 287
VAL A 215
PHE A 312
ILE A 296
 None
 1.03A 5of1B-5xavA:
undetectable		 5of1B-5xavA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE
(Chromobacterium
sp.
USM2) 		3 / 3 LYS A 221
VAL A 397
ASP A 395
 None
 0.65A 6fgdA-5xavA:
2.4		 6fgdA-5xavA:
22.93