SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xaz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 5 GLY A 161
GLN A 163
VAL A 179
SER A 166
 None
 1.44A 1p6kB-5xazA:
undetectable		 1p6kB-5xazA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 4 VAL A  15
ALA A  19
LEU A 105
PHE A  22
 None
 1.08A 1q97B-5xazA:
undetectable		 1q97B-5xazA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 5 GLY A 161
GLN A 163
VAL A 179
SER A 166
 None
 1.45A 1rs6B-5xazA:
undetectable		 1rs6B-5xazA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 5 GLY A 161
GLN A 163
VAL A 179
SER A 166
 None
 1.46A 1zzuB-5xazA:
undetectable		 1zzuB-5xazA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		5 / 12 PHE A 201
ILE A  82
ILE A  81
ALA A 162
ARG A 178
 None
 1.04A 2j0dA-5xazA:
undetectable		 2j0dA-5xazA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 7 LEU A 176
VAL A 179
THR A 180
ASP A  83
 None
 0.91A 2qblA-5xazA:
undetectable		 2qblA-5xazA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 5 ILE A  35
PHE A  22
ASP A  23
GLU A  24
 None
 1.00A 3kp6A-5xazA:
undetectable
3kp6B-5xazA:
undetectable		 3kp6A-5xazA:
20.61
3kp6B-5xazA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 6 THR A  85
GLN A  58
LEU A  61
GLU A  59
 None
 0.95A 4nc3A-5xazA:
4.8		 4nc3A-5xazA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		5 / 9 VAL A  15
ALA A  33
THR A  31
VAL A  21
ALA A  18
 None
 1.23A 4oqrA-5xazA:
undetectable		 4oqrA-5xazA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN
(Streptomyces
fradiae) 		4 / 5 GLY A 161
GLN A 163
VAL A 179
SER A 166
 None
 1.46A 5vunA-5xazA:
undetectable		 5vunA-5xazA:
22.38