SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		3 / 3 ASP A1708
LEU A1748
LEU A1747
 None
 0.66A 1ikeA-5xbfA:
undetectable		 1ikeA-5xbfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5xbf HARMONIN
(Homo
sapiens) 		4 / 8 GLU B 501
LYS B 451
SER B 474
ASP B 473
 None
 1.16A 1knyA-5xbfB:
undetectable
1knyB-5xbfB:
undetectable		 1knyA-5xbfB:
18.36
1knyB-5xbfB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		3 / 3 ASP A1708
LEU A1748
LEU A1747
 None
 0.70A 1np1B-5xbfA:
undetectable		 1np1B-5xbfA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 7 PHE A1997
LEU A1920
GLY A1922
ILE A2001
 None
 0.82A 1p2yA-5xbfA:
undetectable		 1p2yA-5xbfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		5 / 12 GLU A1727
ASN A1723
ASP A1680
ILE A1674
GLY A1730
 None
 1.27A 1q8jA-5xbfA:
undetectable		 1q8jA-5xbfA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 7 ALA A2029
ARG A1892
ASN A2031
GLU A1915
 None
 1.34A 1t9wA-5xbfA:
undetectable		 1t9wA-5xbfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 6 PHE A1858
ARG A1822
GLY A1778
THR A1777
 None
 1.22A 2f7fA-5xbfA:
undetectable		 2f7fA-5xbfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		5 / 12 ARG A1780
ILE A1771
ILE A1755
ALA A1792
GLU A1788
 None
 1.17A 2j0dA-5xbfA:
undetectable		 2j0dA-5xbfA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 4 ALA A1935
TYR A1939
ALA A1981
TYR A1982
 None
 1.18A 2wlkA-5xbfA:
undetectable
2wlkB-5xbfA:
undetectable		 2wlkA-5xbfA:
19.58
2wlkB-5xbfA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5xbf HARMONIN
(Homo
sapiens) 		5 / 11 LEU B 468
LEU B 522
SER B 463
LYS B 488
LEU B 535
 None
 1.07A 2xn5A-5xbfB:
undetectable		 2xn5A-5xbfB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		5 / 10 TYR A1711
ILE A1755
ILE A1771
PHE A1697
LEU A1715
 None
 1.40A 3elzB-5xbfA:
undetectable		 3elzB-5xbfA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		3 / 3 ARG A1770
ASP A1861
GLN A1702
 None
 0.77A 3lcvB-5xbfA:
undetectable		 3lcvB-5xbfA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5xbf HARMONIN
UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 6 ILE A2038
THR A2006
VAL A2025
ASP B 547
 None
 1.03A 4iaqA-5xbfA:
undetectable		 4iaqA-5xbfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5xbf HARMONIN
UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 7 ILE A2038
THR A2006
VAL A2025
ASP B 547
 None
 1.03A 4iarA-5xbfA:
undetectable		 4iarA-5xbfA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		5 / 12 LEU A1611
LEU A1654
ILE A1674
ILE A1670
LEU A1649
 None
 1.30A 4j24C-5xbfA:
undetectable		 4j24C-5xbfA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		5 / 12 LEU A1611
LEU A1654
ILE A1674
ILE A1670
LEU A1649
 None
 1.27A 4j26B-5xbfA:
undetectable		 4j26B-5xbfA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 5 TYR A2049
SER A2018
LEU A2077
GLN A2016
 None
None
None
ACT  A2204 ( 4.7A)
 1.28A 4yo9A-5xbfA:
undetectable
4yo9B-5xbfA:
undetectable		 4yo9A-5xbfA:
19.81
4yo9B-5xbfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 6 PHE A1754
LEU A1747
PRO A1743
ARG A1758
 None
 1.38A 4yv5B-5xbfA:
undetectable		 4yv5B-5xbfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 6 PHE A1754
LEU A1747
PRO A1743
ARG A1758
 None
 1.39A 4yv5A-5xbfA:
undetectable		 4yv5A-5xbfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 5xbf HARMONIN
(Homo
sapiens) 		5 / 12 ILE B 533
ALA B 489
GLY B 488
ALA B 490
ILE B 458
 None
 0.84A 5kb6A-5xbfB:
undetectable		 5kb6A-5xbfB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 5xbf HARMONIN
(Homo
sapiens) 		5 / 12 ILE B 533
ALA B 489
GLY B 488
ALA B 490
ILE B 458
 None
 0.85A 5kb6B-5xbfB:
undetectable		 5kb6B-5xbfB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		3 / 3 TYR A2085
SER A2082
TRP A1869
 None
 1.03A 5n8jB-5xbfA:
undetectable		 5n8jB-5xbfA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		3 / 3 TYR A2085
SER A2082
TRP A1869
 None
 1.05A 5n8jA-5xbfA:
undetectable		 5n8jA-5xbfA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens) 		4 / 6 TYR A1939
ILE A1956
ALA A1951
ASP A1983
 None
 1.13A 6hu9m-5xbfA:
undetectable
6hu9q-5xbfA:
1.7		 6hu9m-5xbfA:
21.48
6hu9q-5xbfA:
14.54