SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 10 GLY D 857
PHE D 855
LEU D 804
PHE D 851
LEU D 800
 None
 1.46A 1a8uB-5xbkD:
undetectable		 1a8uB-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 HIS D 718
ALA D 720
GLY D 722
ALA D 758
HIS D 834
 None
 1.17A 1kxhA-5xbkD:
undetectable		 1kxhA-5xbkD:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 5 LEU D 800
VAL D 803
ALA D 809
CYH D 810
 None
 0.91A 1mz9D-5xbkD:
undetectable		 1mz9D-5xbkD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 7 VAL D 903
LEU D 804
ALA D 878
LEU D 882
 None
 0.88A 1pthA-5xbkD:
undetectable		 1pthA-5xbkD:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 7 VAL D 903
LEU D 804
ALA D 878
LEU D 882
 None
 0.89A 1pthB-5xbkD:
undetectable		 1pthB-5xbkD:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 4 LEU D 859
LEU D 889
SER D 893
LEU D 926
 None
 1.16A 1ya3A-5xbkD:
undetectable		 1ya3A-5xbkD:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 VAL D 803
LEU D 804
GLY D 836
ALA D 838
LEU D 772
 None
 1.07A 2aylA-5xbkD:
undetectable		 2aylA-5xbkD:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		6 / 12 VAL D 803
LEU D 804
ILE D 839
GLY D 836
ALA D 838
LEU D 772
 None
 1.24A 2aylB-5xbkD:
undetectable		 2aylB-5xbkD:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 9 THR D 885
GLU D 833
HIS D 834
ALA D 835
LEU D 800
 None
 1.45A 2azqA-5xbkD:
undetectable		 2azqA-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D 989
LEU D 986
LEU D1023
ILE D1026
ILE D1030
 None
 0.94A 2bdmA-5xbkD:
undetectable		 2bdmA-5xbkD:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 8 SER D1012
LEU D 986
LEU D1044
LEU D1048
 None
 0.91A 2bfpA-5xbkD:
undetectable		 2bfpA-5xbkD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 8 SER D1012
LEU D 986
LEU D1044
LEU D1048
 None
 0.91A 2bfpD-5xbkD:
undetectable		 2bfpD-5xbkD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 8 MET D 695
PHE D 699
ALA D 720
LEU D 721
 None
 0.86A 2o01A-5xbkD:
undetectable		 2o01A-5xbkD:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xbk IMPORTIN-4
(Homo
sapiens) 		6 / 12 VAL D 803
LEU D 804
ILE D 839
GLY D 836
ALA D 838
LEU D 772
 None
 1.23A 3n8zB-5xbkD:
undetectable		 3n8zB-5xbkD:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 6 PHE D 851
THR D 885
ALA D 845
ALA D 844
 None
 1.05A 3ns1C-5xbkD:
undetectable		 3ns1C-5xbkD:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 5 LEU D 948
LEU D 945
LEU D 905
SER D 906
 None
 0.91A 3vhuA-5xbkD:
undetectable		 3vhuA-5xbkD:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1491_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5xbk IMPORTIN-4
(Homo
sapiens) 		4 / 4 GLY D 963
TRP D 998
GLU D 997
THR D1000
 None
 1.08A 4at0A-5xbkD:
0.0		 4at0A-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 10 MET D 695
PHE D 699
ALA D 720
LEU D 721
ALA D 841
 None
 1.28A 4fe1A-5xbkD:
undetectable
4fe1J-5xbkD:
undetectable		 4fe1A-5xbkD:
6.90
4fe1J-5xbkD:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D1063
ALA D1062
LEU D1048
ILE D1026
LEU D1044
 None
 1.08A 4j24D-5xbkD:
undetectable		 4j24D-5xbkD:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 GLU D 914
ASP D 912
ARG D 956
GLN D 887
ALA D 883
 None
 1.29A 4uroC-5xbkD:
undetectable		 4uroC-5xbkD:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 10 PHE D 921
GLY D 930
GLU D 928
LEU D 941
ALA D 883
 None
 1.13A 4wnuD-5xbkD:
undetectable		 4wnuD-5xbkD:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D 904
GLY D 890
LEU D 889
ALA D 934
PHE D 855
 None
 1.11A 4wnwB-5xbkD:
undetectable		 4wnwB-5xbkD:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D1008
PHE D1005
LEU D 991
ILE D 961
LEU D 949
 None
 1.24A 5ienA-5xbkD:
undetectable		 5ienA-5xbkD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D1008
PHE D1005
LEU D 991
ILE D 961
LEU D 949
 None
 1.21A 5ienB-5xbkD:
undetectable		 5ienB-5xbkD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D 904
GLY D 880
ALA D 919
GLU D 837
THR D 881
 None
 1.28A 5x6yA-5xbkD:
undetectable		 5x6yA-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 LEU D 904
GLY D 880
ALA D 919
GLU D 837
THR D 881
 None
 1.13A 5x6yC-5xbkD:
undetectable		 5x6yC-5xbkD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5xbk IMPORTIN-4
(Homo
sapiens) 		5 / 12 VAL D 768
LEU D 796
THR D 808
THR D 776
LEU D 779
 None
 1.13A 6b54A-5xbkD:
undetectable		 6b54A-5xbkD:
undetectable