SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.84A 1c8lA-5xblA:
undetectable		 1c8lA-5xblA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.77A 1gfzA-5xblA:
undetectable		 1gfzA-5xblA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.82A 1l5qA-5xblA:
undetectable		 1l5qA-5xblA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.83A 1l5qB-5xblA:
undetectable		 1l5qB-5xblA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.79A 1l7xA-5xblA:
undetectable		 1l7xA-5xblA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.78A 1l7xB-5xblA:
undetectable		 1l7xB-5xblA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 ASP A 628
TYR A 451
ARG A 629
ALA A 488
 None
 1.14A 2e5dA-5xblA:
undetectable
2e5dB-5xblA:
undetectable		 2e5dA-5xblA:
16.68
2e5dB-5xblA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 ILE A 186
ALA A 299
VAL A 206
PHE A 185
SER A 245
 None
 1.46A 2gl0A-5xblA:
undetectable
2gl0C-5xblA:
undetectable		 2gl0A-5xblA:
9.15
2gl0C-5xblA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 8 TYR A 362
TYR A 359
TYR A 325
HIS A 329
 None
G  B  43 ( 4.8A)
U  B  44 ( 3.6A)
U  B  44 ( 4.4A)
 1.40A 2ha2A-5xblA:
undetectable		 2ha2A-5xblA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 LEU A1203
LEU A1362
ALA A1345
LEU A1163
LEU A1220
 None
 1.31A 2oaxE-5xblA:
undetectable		 2oaxE-5xblA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 ASP A 269
THR A 249
PRO A 250
 G  B  19 ( 4.9A)
None
None
 0.65A 2q64B-5xblA:
undetectable		 2q64B-5xblA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 GLY A 994
THR A 995
PHE A1046
PHE A 970
 None
 1.10A 2qx4A-5xblA:
undetectable
2qx4B-5xblA:
undetectable		 2qx4A-5xblA:
9.93
2qx4B-5xblA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 11 LEU A 153
LEU A 101
LEU A 142
ILE A  79
ILE A 135
 None
A  B  47 ( 3.6A)
None
A  B  48 ( 4.4A)
A  B  46 ( 3.5A)
 1.20A 2uxoB-5xblA:
3.8		 2uxoB-5xblA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 LEU A 106
SER A  96
ASP A  95
GLU A 103
 None
 1.14A 2vn1B-5xblA:
undetectable		 2vn1B-5xblA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 5 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.86A 3bcrA-5xblA:
undetectable		 3bcrA-5xblA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 LYS A 554
LYS A 546
VAL A 549
 None
 1.06A 3brfA-5xblA:
undetectable		 3brfA-5xblA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 GLY A 717
LEU A 720
SER A 719
SER A 937
LEU A 935
 None
 1.27A 3bxoA-5xblA:
undetectable		 3bxoA-5xblA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 HIS A1262
LEU A1087
SER A1088
ARG A 967
PHE A1235
 None
 1.49A 3bxoB-5xblA:
undetectable		 3bxoB-5xblA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.81A 3dd1A-5xblA:
2.2		 3dd1A-5xblA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.76A 3dd1B-5xblA:
undetectable		 3dd1B-5xblA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.79A 3ddsA-5xblA:
undetectable		 3ddsA-5xblA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.78A 3ddsB-5xblA:
undetectable		 3ddsB-5xblA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.79A 3ddwA-5xblA:
undetectable		 3ddwA-5xblA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 PHE A 351
ALA A 360
GLY A 358
TYR A 359
 G  B  43 ( 4.9A)
G  B  43 ( 3.4A)
None
G  B  43 ( 4.8A)
 0.79A 3ddwB-5xblA:
2.2		 3ddwB-5xblA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 LEU A 289
GLN A 285
ALA A 287
LEU A 275
ASP A 276
 None
 1.24A 3gwuA-5xblA:
undetectable		 3gwuA-5xblA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 GLU A 904
LEU A 908
LYS A 913
ASN A 869
 None
 1.39A 3k8mB-5xblA:
undetectable		 3k8mB-5xblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 GLU A 977
LEU A  52
LYS A1096
ASN A  14
 None
 1.42A 3k8mB-5xblA:
undetectable		 3k8mB-5xblA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 LEU A 513
SER A 512
PHE A 626
GLU A 617
ASP A 618
 None
 1.19A 3ko0G-5xblA:
undetectable
3ko0H-5xblA:
undetectable
3ko0I-5xblA:
undetectable
3ko0J-5xblA:
undetectable		 3ko0G-5xblA:
5.97
3ko0H-5xblA:
5.97
3ko0I-5xblA:
5.97
3ko0J-5xblA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 11 GLU A 617
ASP A 618
LEU A 513
SER A 512
PHE A 626
 None
 1.17A 3ko0Q-5xblA:
undetectable
3ko0R-5xblA:
undetectable
3ko0S-5xblA:
undetectable
3ko0T-5xblA:
undetectable		 3ko0Q-5xblA:
5.97
3ko0R-5xblA:
5.97
3ko0S-5xblA:
5.97
3ko0T-5xblA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 TYR A 521
ASN A 668
LEU A 680
ASP A 681
 None
 1.33A 3lslA-5xblA:
undetectable
3lslD-5xblA:
undetectable		 3lslA-5xblA:
11.93
3lslD-5xblA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 TYR A 521
ASN A 668
LEU A 680
ASP A 681
 None
 1.27A 3lslA-5xblA:
undetectable
3lslD-5xblA:
undetectable		 3lslA-5xblA:
11.93
3lslD-5xblA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 TYR A 521
ASN A 668
LEU A 680
ASP A 681
 None
 1.30A 3lslG-5xblA:
undetectable		 3lslG-5xblA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 ILE A 305
HIS A 415
PRO A 316
LEU A 306
 None
 1.25A 3oi8A-5xblA:
undetectable		 3oi8A-5xblA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 GLU A 706
PHE A 693
GLN A 709
 None
 1.01A 3r55A-5xblA:
undetectable		 3r55A-5xblA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 11 ILE A 492
ARG A 635
GLY A 485
ALA A 486
THR A 466
 None
 1.10A 3rukD-5xblA:
undetectable		 3rukD-5xblA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 ASP A 269
THR A 249
PRO A 250
 G  B  19 ( 4.9A)
None
None
 0.59A 3tkgD-5xblA:
undetectable		 3tkgD-5xblA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 9 LEU A 997
LEU A 962
ILE A 761
ILE A 759
GLU A 923
 None
 1.20A 3tmzA-5xblA:
undetectable		 3tmzA-5xblA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 PRO A 871
LEU A 908
ASN A 854
ILE A 841
 None
 1.01A 3u5jA-5xblA:
undetectable		 3u5jA-5xblA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 5 GLU A1357
GLY A1354
TYR A1356
GLU A 746
 None
None
G  B  81 ( 3.9A)
None
 1.25A 3w9tA-5xblA:
undetectable		 3w9tA-5xblA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 5 GLU A1357
GLY A1354
TYR A1356
GLU A 746
 None
None
G  B  81 ( 3.9A)
None
 1.24A 3w9tC-5xblA:
undetectable		 3w9tC-5xblA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 5 GLU A1357
GLY A1354
TYR A1356
GLU A 746
 None
None
G  B  81 ( 3.9A)
None
 1.23A 3w9tD-5xblA:
undetectable		 3w9tD-5xblA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 5 GLU A1357
GLY A1354
TYR A1356
GLU A 746
 None
None
G  B  81 ( 3.9A)
None
 1.24A 3w9tG-5xblA:
undetectable		 3w9tG-5xblA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 ARG A 654
ARG A 557
ASP A 284
 None
 0.79A 3wipG-5xblA:
undetectable
3wipH-5xblA:
undetectable		 3wipG-5xblA:
10.22
3wipH-5xblA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 7 ASN A 436
GLU A 427
GLU A 438
ARG A 424
 None
 0.91A 4mi4B-5xblA:
undetectable
4mi4C-5xblA:
undetectable		 4mi4B-5xblA:
9.95
4mi4C-5xblA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 8 ASN A 436
GLU A 427
GLU A 438
ARG A 424
 None
 0.91A 4mj8B-5xblA:
undetectable
4mj8C-5xblA:
undetectable		 4mj8B-5xblA:
9.76
4mj8C-5xblA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 ALA A 732
GLY A  56
ASP A  54
GLY A 729
ASN A 767
 None
A  B  65 ( 3.4A)
None
U  B  11 ( 4.3A)
None
 1.08A 4obwB-5xblA:
undetectable		 4obwB-5xblA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 LEU A   9
GLY A  17
ALA A  50
SER A  15
LEU A  52
 None
 1.09A 4otyA-5xblA:
undetectable		 4otyA-5xblA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 PHE A  86
THR A 445
LEU A 423
 None
 0.77A 4qztA-5xblA:
undetectable		 4qztA-5xblA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 LEU A   9
GLY A  17
ALA A  50
SER A  15
LEU A  52
 None
 0.98A 4rrwD-5xblA:
undetectable		 4rrwD-5xblA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 LEU A   9
GLY A  17
ALA A  50
SER A  15
LEU A  52
 None
 0.98A 4rrzD-5xblA:
undetectable		 4rrzD-5xblA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 GLU A1253
TYR A1242
GLU A1260
 None
 0.81A 4ryaA-5xblA:
undetectable		 4ryaA-5xblA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 6 GLU A 232
TYR A 192
LEU A 188
PHE A 238
 None
 1.32A 4twdF-5xblA:
2.2
4twdG-5xblA:
undetectable		 4twdF-5xblA:
11.54
4twdG-5xblA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 4 ILE A 956
ASN A 758
ILE A  21
VAL A 992
 None
 1.31A 4uy87-5xblA:
undetectable		 4uy87-5xblA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 GLY A1165
ALA A1217
TYR A1187
GLU A1162
THR A1339
 None
 1.20A 4xt8A-5xblA:
undetectable		 4xt8A-5xblA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		5 / 12 VAL A  27
ILE A  48
GLY A  49
VAL A 743
LEU A   9
 None
 0.99A 4y8wB-5xblA:
undetectable		 4y8wB-5xblA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 TYR A 521
LYS A 546
LYS A 684
 None
 1.16A 5dbyA-5xblA:
undetectable		 5dbyA-5xblA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		6 / 12 ILE A   7
ILE A 956
ILE A 934
ARG A 938
MET A 939
THR A 957
 None
 1.06A 5e72A-5xblA:
undetectable		 5e72A-5xblA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		3 / 3 GLU A 345
TYR A 347
ARG A 340
 None
None
C  B  40 ( 3.4A)
 0.81A 5uunB-5xblA:
undetectable		 5uunB-5xblA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 9 ILE A 852
ILE A 784
ILE A 788
LEU A 791
 None
 0.82A 5vkqB-5xblA:
undetectable
5vkqC-5xblA:
undetectable		 5vkqB-5xblA:
21.62
5vkqC-5xblA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 8 ARG A  66
ARG A  74
VAL A 482
ARG A 165
 G  B  14 ( 3.7A)
U  B  16 ( 2.3A)
None
G  B  18 ( 3.9A)
 1.08A 6fbvD-5xblA:
undetectable		 6fbvD-5xblA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1
(Streptococcus
pyogenes) 		4 / 5 ASP A  54
GLN A1101
GLN A1221
LYS A1096
 None
 0.98A 6g31H-5xblA:
undetectable		 6g31H-5xblA:
4.80