SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xbp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 THR A 241
GLY A 413
GLY A 296
GLY A 202
 None
 0.60A 1d0vA-5xbpA:
undetectable		 1d0vA-5xbpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.49A 1fk9A-5xbpA:
undetectable		 1fk9A-5xbpA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 9 GLU A 323
ILE A 317
ASP A  60
LEU A  59
GLY A  58
 None
 1.46A 1i00A-5xbpA:
undetectable		 1i00A-5xbpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 9 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.44A 1ikvA-5xbpA:
undetectable		 1ikvA-5xbpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.42A 1ikwA-5xbpA:
undetectable		 1ikwA-5xbpA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 THR A 241
GLY A 413
GLY A 296
GLY A 202
 None
 0.61A 1jhaA-5xbpA:
undetectable		 1jhaA-5xbpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.47A 1lw0A-5xbpA:
1.2		 1lw0A-5xbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 11 ALA C 124
ARG C 175
LEU C 172
GLU C  40
LEU C  37
 None
 0.94A 1mjlA-5xbpC:
undetectable
1mjlB-5xbpC:
undetectable		 1mjlA-5xbpC:
19.54
1mjlB-5xbpC:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 6 PHE A 430
ARG A 416
ALA A 420
ILE A  32
 None
 1.13A 1oniH-5xbpA:
undetectable
1oniI-5xbpA:
undetectable		 1oniH-5xbpA:
14.89
1oniI-5xbpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 9 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.43A 1vrtA-5xbpA:
0.9		 1vrtA-5xbpA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 4 ILE A 214
ASP A 362
LEU C 189
ARG A 216
 None
 1.48A 2a7qA-5xbpA:
undetectable		 2a7qA-5xbpA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 6 LEU C  37
LEU C  36
LEU C 172
LEU C  44
 None
 0.90A 2ab2A-5xbpC:
undetectable		 2ab2A-5xbpC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 SER A 410
MET A 240
GLY A 405
TYR A 167
ALA A 406
 None
 1.22A 2avdB-5xbpA:
undetectable		 2avdB-5xbpA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.47A 2hndA-5xbpA:
undetectable		 2hndA-5xbpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.49A 2hnyA-5xbpA:
1.3		 2hnyA-5xbpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 LEU C 184
ASN C 187
LEU C 188
GLY A 353
VAL C  84
 None
 1.24A 2q7lA-5xbpC:
undetectable		 2q7lA-5xbpC:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 LEU A 294
ILE A 289
ARG A 286
VAL A 401
GLY A 399
 None
 1.18A 2qd4B-5xbpA:
undetectable		 2qd4B-5xbpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 7 GLY A 405
ALA A 406
LEU A 385
SER A 236
 None
 0.91A 2wekB-5xbpA:
undetectable		 2wekB-5xbpA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 6 TYR A 147
PHE A 145
PHE A 172
PHE A 304
 None
 1.49A 3af3A-5xbpA:
undetectable		 3af3A-5xbpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 397
GLY A 405
GLY A 237
HIS A 206
SER A 249
 None
None
None
FE  A 501 (-2.9A)
None
 1.22A 3dlcA-5xbpA:
undetectable		 3dlcA-5xbpA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 247
ILE A 382
 None
 1.29A 3iizA-5xbpA:
undetectable		 3iizA-5xbpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 296
ILE A 382
 None
 1.49A 3iizA-5xbpA:
undetectable		 3iizA-5xbpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 GLU A  61
GLY A 185
GLU C  69
GLY A  92
ASN C  81
 None
 1.38A 3jzjA-5xbpA:
undetectable		 3jzjA-5xbpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 9 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.49A 3lp0A-5xbpA:
1.1		 3lp0A-5xbpA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.47A 3lp1A-5xbpA:
1.1		 3lp1A-5xbpA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 SER A 213
ASP A 359
ASN A 363
 None
 1.01A 3lsfB-5xbpA:
undetectable
3lsfE-5xbpA:
undetectable		 3lsfB-5xbpA:
21.48
3lsfE-5xbpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2;
Diaphorobacter
sp.
DS2) 		3 / 3 SER A 260
ASP A 262
ASN C  90
 None
 1.03A 3lsfB-5xbpA:
undetectable
3lsfE-5xbpA:
undetectable		 3lsfB-5xbpA:
21.48
3lsfE-5xbpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 ASP A 359
ASN A 363
SER A 213
 None
 1.00A 3lsfB-5xbpA:
undetectable
3lsfE-5xbpA:
undetectable		 3lsfB-5xbpA:
21.48
3lsfE-5xbpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 GLN C  92
PRO C  59
GLN C 171
GLU C  60
 None
 1.08A 3oyaA-5xbpC:
undetectable		 3oyaA-5xbpC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.41A 3qipA-5xbpA:
undetectable		 3qipA-5xbpA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 GLY A 296
VAL A 201
ILE A 204
PHE A 222
 None
 0.93A 4fglD-5xbpA:
undetectable		 4fglD-5xbpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 247
ILE A 382
 None
 1.29A 4jxcA-5xbpA:
undetectable		 4jxcA-5xbpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 TRP A 193
GLN A 369
THR A 195
 None
 0.93A 4m2xA-5xbpA:
undetectable		 4m2xA-5xbpA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 PRO C 108
ASN C 106
HIS C 100
 None
 0.73A 4ma3H-5xbpC:
undetectable
4ma3L-5xbpC:
undetectable		 4ma3H-5xbpC:
18.80
4ma3L-5xbpC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 GLU C  54
GLN C 171
ILE C 170
LEU C 172
 None
 0.84A 4mj8A-5xbpC:
undetectable		 4mj8A-5xbpC:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 LEU A 305
MET A 248
TYR A 254
 None
 0.95A 4p6xG-5xbpA:
undetectable		 4p6xG-5xbpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 ARG A 216
THR A 210
TRP C 107
 None
 1.20A 4ug5A-5xbpA:
undetectable		 4ug5A-5xbpA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 LYS A 190
ARG C 144
VAL C 151
 None
 0.74A 4x3uA-5xbpA:
undetectable
4x3uB-5xbpA:
undetectable		 4x3uA-5xbpA:
10.02
4x3uB-5xbpA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 4 ARG C 147
GLY C 148
GLU C 150
 None
 0.51A 4z2dB-5xbpC:
undetectable
4z2dC-5xbpC:
undetectable		 4z2dB-5xbpC:
16.26
4z2dC-5xbpC:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 7 PHE A 430
GLY A 245
THR A 241
LEU A 441
 None
 0.89A 4zdzA-5xbpA:
undetectable		 4zdzA-5xbpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 7 PHE A 430
GLY A 245
THR A 241
LEU A 441
 None
 0.90A 4ze3A-5xbpA:
undetectable		 4ze3A-5xbpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 7 PHE A 430
GLY A 245
THR A 241
LEU A 441
 None
 0.89A 5esmA-5xbpA:
undetectable		 5esmA-5xbpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 247
ILE A 382
 None
 1.31A 5fepA-5xbpA:
undetectable		 5fepA-5xbpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 296
ILE A 382
 None
 1.49A 5fepA-5xbpA:
undetectable		 5fepA-5xbpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 247
ILE A 382
 None
 1.29A 5fesA-5xbpA:
undetectable		 5fesA-5xbpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 TYR A 415
GLN A 239
SER A 249
GLY A 296
ILE A 382
 None
 1.49A 5fesA-5xbpA:
undetectable		 5fesA-5xbpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 ARG A 216
THR A 210
TRP C 107
 None
 1.27A 5g6cA-5xbpA:
undetectable		 5g6cA-5xbpA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 11 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.48A 5hbmA-5xbpA:
undetectable		 5hbmA-5xbpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 6 LYS A 312
PHE A 329
SER C  67
VAL C  84
 None
 1.20A 5hesA-5xbpA:
undetectable		 5hesA-5xbpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 PHE A 430
GLY A 245
THR A 241
LEU A 441
 None
 0.85A 5hs1A-5xbpA:
undetectable		 5hs1A-5xbpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 GLY A 245
TYR A 160
ARG A  35
ALA A 154
ILE A 422
 None
 1.19A 5igvA-5xbpA:
undetectable		 5igvA-5xbpA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 ILE A 204
PRO A 232
LEU A 225
GLY A 237
GLY A 405
 None
 1.15A 5l6eA-5xbpA:
undetectable		 5l6eA-5xbpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 10 VAL A  53
GLU C  69
LEU A 157
ALA A  55
PRO A 184
 None
 1.29A 5mm4B-5xbpA:
undetectable		 5mm4B-5xbpA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		3 / 3 ASP C  14
PHE C 176
ARG C  68
 None
 0.99A 5yw0A-5xbpC:
undetectable		 5yw0A-5xbpC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2;
Diaphorobacter
sp.
DS2) 		4 / 6 SER A 368
GLU C 150
ARG C 144
ARG C 147
 None
 1.22A 5zw4A-5xbpA:
undetectable		 5zw4A-5xbpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		5 / 12 SER A 220
GLY A 307
TRP A 356
ASN A 295
VAL A 207
 None
 1.07A 6a94A-5xbpA:
undetectable		 6a94A-5xbpA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5xbp 3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2) 		4 / 8 GLU C  40
LEU C  37
HIS C 135
LEU C 134
 None
 1.27A 6cbzA-5xbpC:
undetectable		 6cbzA-5xbpC:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT
(Diaphorobacter
sp.
DS2;
Diaphorobacter
sp.
DS2) 		4 / 5 ASN C 109
GLY A 218
HIS C 100
ASP A 359
 None
 1.28A 6gh9A-5xbpC:
undetectable		 6gh9A-5xbpC:
18.23