SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 8 PRO A  39
THR A  43
PRO A  44
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 2.3A)
 0.48A 1h4oB-5xbqA:
18.2		 1h4oB-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 8 PRO A  39
THR A  43
PRO A  44
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 2.3A)
 0.42A 1h4oG-5xbqA:
18.1		 1h4oG-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 8 PRO A  39
THR A  43
PRO A  44
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 2.3A)
 0.52A 1oc3A-5xbqA:
18.0		 1oc3A-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 11 VAL A  13
ILE A  20
LEU A  22
HIS A  17
PHE A  26
 None
 1.13A 2dg9A-5xbqA:
undetectable		 2dg9A-5xbqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 7 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.59A 2v2gA-5xbqA:
24.4
2v2gB-5xbqA:
24.6		 2v2gA-5xbqA:
undetectable
2v2gB-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 7 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.57A 2v2gA-5xbqA:
24.4
2v2gB-5xbqA:
24.6		 2v2gA-5xbqA:
undetectable
2v2gB-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 7 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.58A 2v2gC-5xbqA:
24.4
2v2gD-5xbqA:
24.5		 2v2gC-5xbqA:
undetectable
2v2gD-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 7 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.60A 2v2gC-5xbqA:
24.4
2v2gD-5xbqA:
24.5		 2v2gC-5xbqA:
undetectable
2v2gD-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 8 THR A  43
PRO A  44
VAL A  45
ARG A 121
ALA A 140
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
None
 0.50A 2v32A-5xbqA:
24.4
2v32B-5xbqA:
24.5		 2v32A-5xbqA:
undetectable
2v32B-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 8 PRO A  39
THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.57A 2v32C-5xbqA:
24.4
2v32D-5xbqA:
25.7		 2v32C-5xbqA:
undetectable
2v32D-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 8 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.58A 2v32C-5xbqA:
24.4
2v32D-5xbqA:
25.7		 2v32C-5xbqA:
undetectable
2v32D-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		6 / 9 PRO A  39
THR A  43
PRO A  44
VAL A  45
ARG A 121
ALA A 140
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
None
 0.52A 2v41A-5xbqA:
21.8
2v41B-5xbqA:
24.4		 2v41A-5xbqA:
undetectable
2v41B-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		6 / 9 PRO A  39
THR A  43
PRO A  44
VAL A  45
ARG A 121
ALA A 140
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
None
 0.54A 2v41A-5xbqA:
24.3
2v41B-5xbqA:
24.4		 2v41A-5xbqA:
undetectable
2v41B-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 8 PRO A  39
THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.58A 2v41C-5xbqA:
25.9
2v41D-5xbqA:
26.2		 2v41C-5xbqA:
undetectable
2v41D-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 8 PRO A  39
THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.60A 2v41C-5xbqA:
25.9
2v41D-5xbqA:
26.2		 2v41C-5xbqA:
undetectable
2v41D-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 7 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.49A 2v41E-5xbqA:
24.2
2v41F-5xbqA:
24.4		 2v41E-5xbqA:
undetectable
2v41F-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 7 THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.58A 2v41E-5xbqA:
24.2
2v41F-5xbqA:
24.4		 2v41E-5xbqA:
undetectable
2v41F-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 8 THR A  43
PRO A  44
VAL A  45
ARG A 121
ALA A 140
 OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
None
 0.54A 2v41G-5xbqA:
24.5
2v41H-5xbqA:
24.3		 2v41G-5xbqA:
undetectable
2v41H-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 8 PRO A  39
THR A  43
PRO A  44
VAL A  45
ARG A 121
 OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 3.0A)
OCS  A  46 ( 2.3A)
 0.57A 2v41G-5xbqA:
24.5
2v41H-5xbqA:
24.3		 2v41G-5xbqA:
undetectable
2v41H-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 9 LEU A  22
LYS A   7
VAL A 126
GLY A 130
LEU A  35
 None
 1.38A 4b3oA-5xbqA:
undetectable		 4b3oA-5xbqA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 153
LEU A 152
ALA A 134
ILE A  98
LEU A  22
 None
 1.13A 5hbsA-5xbqA:
undetectable		 5hbsA-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		4 / 9 PHE A  42
VAL A  97
THR A  16
ILE A  82
 None
 1.06A 5lg3I-5xbqA:
undetectable		 5lg3I-5xbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 5xbq PEROXIREDOXIN
(Pyrococcus
horikoshii) 		3 / 3 HIS A  38
ASP A  41
HIS A  78
 OCS  A  46 ( 4.6A)
None
None
 0.77A 5oexA-5xbqA:
undetectable		 5oexA-5xbqA:
undetectable