SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 THR A 111
SER A  79
LEU A  10
PHE A 161
VAL A 147
 None
 1.22A 1q23H-5xc3A:
undetectable
1q23I-5xc3A:
undetectable		 1q23H-5xc3A:
24.77
1q23I-5xc3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TRP A 100
THR A  62
TYR A  75
 None
 1.11A 2a3aA-5xc3A:
3.2		 2a3aA-5xc3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TRP A 100
THR A  62
TYR A  75
 None
 1.14A 2a3aB-5xc3A:
3.2		 2a3aB-5xc3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TRP A 100
THR A  62
TYR A  75
 None
 1.14A 2a3bA-5xc3A:
3.2		 2a3bA-5xc3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 PHE A 161
ILE A   8
VAL A  16
LEU A  10
LEU A 160
 None
None
GDP  A1200 (-4.0A)
None
None
 1.35A 4qzuA-5xc3A:
undetectable		 4qzuA-5xc3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ALA A 149
ASP A  61
GLY A  12
GLU A  66
 None
MG  A1201 ( 4.0A)
None
GDP  A1200 ( 4.7A)
 0.89A 5bs8A-5xc3A:
undetectable
5bs8B-5xc3A:
3.1
5bs8C-5xc3A:
undetectable		 5bs8A-5xc3A:
14.71
5bs8B-5xc3A:
20.40
5bs8C-5xc3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ASP A  61
LEU A  10
THR A  62
VAL A  16
 MG  A1201 ( 4.0A)
None
None
GDP  A1200 (-4.0A)
 1.12A 5ov9A-5xc3A:
2.4		 5ov9A-5xc3A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5xc3 PROBABLE RAB-RELATED
GTPASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ARG A 105
TYR A  76
VAL A  97
ASP A 141
PHE A 138
 None
 1.49A 5vlmC-5xc3A:
undetectable		 5vlmC-5xc3A:
17.41