SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HH9_A_VIBA702_1 (THIAMIN PYROPHOSPHOKINASE)	5xc4	ENDO-BETA-1,4-GLUCAN ASE (Ampullaria crossean)	5 / 9	ASP A 7 VAL A 86 TYR A 132 SER A 129 ASN A 128	None	1.31A	2hh9A-5xc4A: 0.0 2hh9B-5xc4A: 0.0	2hh9A-5xc4A: 12.87 2hh9B-5xc4A: 12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HH9_B_VIBB701_1 (THIAMIN PYROPHOSPHOKINASE)	5xc4	ENDO-BETA-1,4-GLUCAN ASE (Ampullaria crossean)	5 / 9	VAL A 86 TYR A 132 SER A 129 ASN A 128 ASP A 7	None	1.30A	2hh9A-5xc4A: 0.0 2hh9B-5xc4A: 0.0	2hh9A-5xc4A: 12.87 2hh9B-5xc4A: 12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD4_A_STIA604_1 (TYROSINE-PROTEIN KINASE ABL1)	5xc4	ENDO-BETA-1,4-GLUCAN ASE (Ampullaria crossean)	4 / 5	TYR A 170 VAL A 99 PHE A 44 GLY A 34	None	1.25A	6hd4A-5xc4A: undetectable	6hd4A-5xc4A: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD4_A_STIA604_1 (TYROSINE-PROTEIN KINASE ABL1)	5xc4	ENDO-BETA-1,4-GLUCAN ASE (Ampullaria crossean)	4 / 5	TYR A 170 VAL A 145 PHE A 44 GLY A 34	None	1.24A	6hd4A-5xc4A: undetectable	6hd4A-5xc4A: 19.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2HH9_A_VIBA702_1","THIAMIN PYROPHOSPHOKINASE;THIAMIN PYROPHOSPHOKINASE","5xc4","ENDO-BETA-1,4-GLUCANASE","Ampullaria crossean",5,"ASP A   7;VAL A  86;TYR A 132;SER A 129;ASN A 128","None","1.31A","2hh9A-5xc4A:0.0;2hh9B-5xc4A:0.0","2hh9A-5xc4A:12.87;2hh9B-5xc4A:12.87"],["2HH9_B_VIBB701_1","THIAMIN PYROPHOSPHOKINASE;THIAMIN PYROPHOSPHOKINASE","5xc4","ENDO-BETA-1,4-GLUCANASE","Ampullaria crossean",5,"VAL A  86;TYR A 132;SER A 129;ASN A 128;ASP A   7","None","1.30A","2hh9A-5xc4A:0.0;2hh9B-5xc4A:0.0","2hh9A-5xc4A:12.87;2hh9B-5xc4A:12.87"],["6HD4_A_STIA604_1","TYROSINE-PROTEIN KINASE ABL1","5xc4","ENDO-BETA-1,4-GLUCANASE","Ampullaria crossean",4,"TYR A 170;VAL A  99;PHE A  44;GLY A  34","None","1.25A","6hd4A-5xc4A:undetectable","6hd4A-5xc4A:19.57"],["6HD4_A_STIA604_1","TYROSINE-PROTEIN KINASE ABL1","5xc4","ENDO-BETA-1,4-GLUCANASE","Ampullaria crossean",4,"TYR A 170;VAL A 145;PHE A  44;GLY A  34","None","1.24A","6hd4A-5xc4A:undetectable","6hd4A-5xc4A:19.57"]]