SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 6 PRO A 178
PHE A 249
ILE A 210
SER A 244
 None
 1.19A 1sbrA-5xcbA:
2.7
1sbrB-5xcbA:
2.8		 1sbrA-5xcbA:
17.09
1sbrB-5xcbA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		3 / 3 LYS A 192
ASP A 315
ASP A 331
 None
 0.70A 2br4D-5xcbA:
undetectable		 2br4D-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 LEU A  95
ILE A  92
ALA A 104
PHE A 103
LEU A  57
 None
 1.15A 2qb4A-5xcbA:
undetectable		 2qb4A-5xcbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 11 LEU A  95
ILE A  92
ALA A 104
PHE A 103
LEU A  57
 None
 1.16A 2qjuA-5xcbA:
undetectable		 2qjuA-5xcbA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 LEU A 329
THR A 330
ALA A 146
THR A 177
ASN A 318
 None
 1.17A 3a35A-5xcbA:
undetectable		 3a35A-5xcbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 LEU A 329
THR A 330
ALA A 146
THR A 177
ASN A 318
 None
 1.20A 3a3bA-5xcbA:
undetectable		 3a3bA-5xcbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 GLY A 132
ALA A  60
ASP A  59
ILE A  61
ILE A  92
 None
 0.98A 3ogpA-5xcbA:
undetectable		 3ogpA-5xcbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 GLY A 132
ALA A  60
ASP A  59
ILE A  61
ILE A  92
 None
 0.98A 3ogpB-5xcbA:
undetectable		 3ogpB-5xcbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 4 ASN A  96
GLY A  97
GLU A  98
LYS A 101
 None
 1.50A 3r2cA-5xcbA:
undetectable		 3r2cA-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 7 ILE A 154
LYS A 109
PHE A  78
GLY A  85
 None
 1.18A 3sj0X-5xcbA:
undetectable		 3sj0X-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 ILE A 154
LYS A 109
ILE A 111
PHE A  78
GLY A  85
 None
 1.43A 3sj4X-5xcbA:
undetectable		 3sj4X-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 LEU A  75
LEU A  57
ASN A  72
LEU A  58
VAL A 155
 None
 1.25A 3zqtA-5xcbA:
undetectable		 3zqtA-5xcbA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 6 LEU A 131
ASP A 168
VAL A 136
ALA A  54
 None
 0.90A 4nkvC-5xcbA:
undetectable		 4nkvC-5xcbA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		3 / 3 LYS A  40
ASN A 166
ASP A 130
 None
 0.70A 4o1eA-5xcbA:
undetectable		 4o1eA-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 ALA A 292
TYR A 255
ILE A 271
GLY A 239
VAL A 259
 None
 1.24A 4r1zA-5xcbA:
undetectable		 4r1zA-5xcbA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 ALA A  66
TYR A  67
ASP A  65
GLY A 162
TYR A 167
 None
 1.30A 6fhwA-5xcbA:
2.2		 6fhwA-5xcbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 5xcb PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 ALA A  66
TYR A  67
ASP A  65
GLY A 162
TYR A 167
 None
 1.30A 6fhwB-5xcbA:
2.6		 6fhwB-5xcbA:
20.88