SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 ASN A 302
ILE A 443
ILE A 458
ASP A 457
GLY A 339
 None
 1.20A 2dtjA-5xccA:
undetectable
2dtjB-5xccA:
undetectable		 2dtjA-5xccA:
undetectable
2dtjB-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 5 SER A 325
SER A 140
VAL A 322
SER A 143
 None
 1.35A 2j9cA-5xccA:
2.2
2j9cB-5xccA:
1.7
2j9cC-5xccA:
2.3		 2j9cA-5xccA:
undetectable
2j9cB-5xccA:
undetectable
2j9cC-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 7 SER A 325
SER A 140
VAL A 322
SER A 143
 None
 1.35A 2j9cA-5xccA:
2.8
2j9cB-5xccA:
1.7
2j9cC-5xccA:
2.3		 2j9cA-5xccA:
undetectable
2j9cB-5xccA:
undetectable
2j9cC-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 LEU A 329
THR A 330
ALA A 146
THR A 177
ASN A 318
 None
 1.15A 3a35A-5xccA:
undetectable		 3a35A-5xccA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 LEU A 329
THR A 330
ALA A 146
THR A 177
ASN A 318
 None
 1.18A 3a3bA-5xccA:
undetectable		 3a3bA-5xccA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A  55
PHE A  78
ASN A  72
LEU A 107
PHE A 103
 None
 1.15A 3ay0A-5xccA:
undetectable		 3ay0A-5xccA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A  55
PHE A  78
ASN A  72
LEU A 107
PHE A 103
 None
 1.18A 3ay0B-5xccA:
undetectable		 3ay0B-5xccA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A 134
VAL A 157
GLY A 132
GLN A 125
GLY A  41
 None
 1.27A 3km6A-5xccA:
undetectable		 3km6A-5xccA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 TYR A 134
VAL A 157
GLY A 132
GLN A 125
GLY A  41
 None
 1.25A 3kmoA-5xccA:
undetectable		 3kmoA-5xccA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 GLY A 132
ALA A  60
ASP A  59
ILE A  61
ILE A  92
 None
 0.96A 3ogpB-5xccA:
undetectable		 3ogpB-5xccA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A 339
ASN A 464
ILE A 427
GLY A 399
ASN A 197
 None
 1.07A 3ps9A-5xccA:
undetectable		 3ps9A-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 8 ILE A 300
LEU A 398
LYS A 377
GLY A 378
 None
 1.01A 3selX-5xccA:
undetectable		 3selX-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		4 / 6 LEU A 131
ASP A 168
VAL A 136
ALA A  54
 None
 0.97A 4nkvC-5xccA:
undetectable		 4nkvC-5xccA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		3 / 3 LYS A  40
ASN A 166
ASP A 130
 None
 0.77A 4o1eA-5xccA:
undetectable		 4o1eA-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 9 ALA A 292
TYR A 255
ILE A 271
GLY A 239
VAL A 259
 None
 1.24A 4r1zA-5xccA:
undetectable		 4r1zA-5xccA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		3 / 3 ASP A 200
ASN A 197
ASP A 363
 None
 0.80A 5vopA-5xccA:
undetectable		 5vopA-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		3 / 3 ASP A 200
ASN A 197
ASP A 363
 None
 0.84A 5vopB-5xccA:
undetectable		 5vopB-5xccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5xcc PROBABLE SURFACE
PROTEIN
(Clostridium
perfringens) 		5 / 12 PHE A 338
SER A 195
ALA A 429
GLY A 435
GLY A 307
 None
 0.96A 5w4zB-5xccA:
undetectable		 5w4zB-5xccA:
14.63