SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5xct VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus) 		5 / 12 ASN B  34
GLY B  46
VAL B  58
GLN B   6
LEU B  21
 None
 1.41A 1nhzA-5xctB:
undetectable		 1nhzA-5xctB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5xct VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus) 		5 / 10 TYR B  32
GLY A  96
ILE B  48
ASN B  53
VAL B  36
 None
 1.28A 3ay0B-5xctB:
undetectable		 3ay0B-5xctB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.40A 3jwtA-5xctA:
undetectable
3jwtB-5xctA:
undetectable		 3jwtA-5xctA:
19.69
3jwtB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.35A 3jwuA-5xctA:
undetectable
3jwuB-5xctA:
undetectable		 3jwuA-5xctA:
19.69
3jwuB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.35A 3jwuA-5xctA:
undetectable
3jwuB-5xctA:
undetectable		 3jwuA-5xctA:
19.69
3jwuB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.34A 3jwvA-5xctA:
undetectable
3jwvB-5xctA:
undetectable		 3jwvA-5xctA:
19.69
3jwvB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.43A 3jx1A-5xctA:
undetectable
3jx1B-5xctA:
undetectable		 3jx1A-5xctA:
16.71
3jx1B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.37A 3nlkA-5xctA:
undetectable
3nlkB-5xctA:
undetectable		 3nlkA-5xctA:
19.69
3nlkB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.36A 3nlnA-5xctA:
undetectable
3nlnB-5xctA:
undetectable		 3nlnA-5xctA:
19.69
3nlnB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.36A 3nloA-5xctA:
undetectable
3nloB-5xctA:
undetectable		 3nloA-5xctA:
19.69
3nloB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.34A 3nloA-5xctA:
undetectable
3nloB-5xctA:
undetectable		 3nloA-5xctA:
19.69
3nloB-5xctA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.38A 3nlyA-5xctA:
undetectable
3nlyB-5xctA:
undetectable		 3nlyA-5xctA:
16.71
3nlyB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 8 ILE A  77
TYR A  79
SER A  70
THR A  17
 None
 0.49A 3pwwA-5xctA:
undetectable		 3pwwA-5xctA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 THR A  52
GLY A  55
PRO A  57
ASN A  52
 None
 1.27A 3u8qA-5xctA:
undetectable		 3u8qA-5xctA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 5xct VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus) 		5 / 11 GLN B   6
PHE B  98
GLY B  99
SER A  44
GLY B  46
 None
 1.14A 3v3nD-5xctB:
undetectable		 3v3nD-5xctB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.30A 4ctrA-5xctA:
undetectable
4ctrB-5xctA:
undetectable		 4ctrA-5xctA:
16.71
4ctrB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.30A 4ctrA-5xctA:
undetectable
4ctrB-5xctA:
undetectable		 4ctrA-5xctA:
16.71
4ctrB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.33A 4cttA-5xctA:
undetectable
4cttB-5xctA:
undetectable		 4cttA-5xctA:
16.71
4cttB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.37A 4ctuA-5xctA:
undetectable
4ctuB-5xctA:
undetectable		 4ctuA-5xctA:
16.71
4ctuB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.36A 4d32A-5xctA:
undetectable
4d32B-5xctA:
undetectable		 4d32A-5xctA:
16.71
4d32B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.38A 4jseA-5xctA:
undetectable
4jseB-5xctA:
undetectable		 4jseA-5xctA:
16.71
4jseB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.36A 4jseA-5xctA:
undetectable
4jseB-5xctA:
undetectable		 4jseA-5xctA:
16.71
4jseB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.36A 4jsiA-5xctA:
undetectable
4jsiB-5xctA:
undetectable		 4jsiA-5xctA:
16.71
4jsiB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.33A 4k5fA-5xctA:
undetectable
4k5fB-5xctA:
undetectable		 4k5fA-5xctA:
16.71
4k5fB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 12 ALA A  60
ASN A  82
ILE A  82
LEU A  80
GLY A  65
 None
 0.92A 4nkvB-5xctA:
undetectable		 4nkvB-5xctA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5xct VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLY A  33
GLN A  35
ALA A  32
LEU A   4
ASN B  34
 None
 1.24A 4pb1A-5xctA:
undetectable		 4pb1A-5xctA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.32A 4ugzA-5xctA:
undetectable
4ugzB-5xctA:
undetectable		 4ugzA-5xctA:
16.71
4ugzB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.32A 4uh0A-5xctA:
undetectable
4uh0B-5xctA:
undetectable		 4uh0A-5xctA:
16.71
4uh0B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.33A 4uh0A-5xctA:
undetectable
4uh0B-5xctA:
undetectable		 4uh0A-5xctA:
16.71
4uh0B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.31A 4uh3A-5xctA:
undetectable
4uh3B-5xctA:
undetectable		 4uh3A-5xctA:
16.71
4uh3B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.33A 4uppA-5xctA:
undetectable
4uppB-5xctA:
undetectable		 4uppA-5xctA:
16.71
4uppB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.09A 4w5oA-5xctA:
undetectable		 4w5oA-5xctA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5xct VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus) 		3 / 3 ALA B  89
TRP B  96
VAL B  97
 None
 0.17A 4w9nC-5xctB:
undetectable		 4w9nC-5xctB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.11A 4z4hA-5xctA:
undetectable		 4z4hA-5xctA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.38A 5ad4A-5xctA:
undetectable
5ad4B-5xctA:
undetectable		 5ad4A-5xctA:
16.71
5ad4B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.34A 5ad6A-5xctA:
undetectable
5ad6B-5xctA:
undetectable		 5ad6A-5xctA:
16.71
5ad6B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.32A 5ad7A-5xctA:
undetectable
5ad7B-5xctA:
undetectable		 5ad7A-5xctA:
16.71
5ad7B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.32A 5ad8A-5xctA:
undetectable
5ad8B-5xctA:
undetectable		 5ad8A-5xctA:
16.71
5ad8B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.33A 5adaA-5xctA:
undetectable
5adaB-5xctA:
undetectable		 5adaA-5xctA:
16.71
5adaB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.32A 5adaA-5xctA:
undetectable
5adaB-5xctA:
undetectable		 5adaA-5xctA:
16.71
5adaB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.31A 5adeA-5xctA:
undetectable
5adeB-5xctA:
undetectable		 5adeA-5xctA:
16.94
5adeB-5xctA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.34A 5fvpA-5xctA:
undetectable
5fvpB-5xctA:
undetectable		 5fvpA-5xctA:
16.71
5fvpB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.30A 5fvpA-5xctA:
undetectable
5fvpB-5xctA:
undetectable		 5fvpA-5xctA:
16.71
5fvpB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.34A 5fw0A-5xctA:
undetectable
5fw0B-5xctA:
undetectable		 5fw0A-5xctA:
16.71
5fw0B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.10A 5ki6A-5xctA:
undetectable		 5ki6A-5xctA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.24A 5unuA-5xctA:
undetectable
5unuB-5xctA:
undetectable		 5unuA-5xctA:
16.71
5unuB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.30A 5unvA-5xctA:
undetectable
5unvB-5xctA:
undetectable		 5unvA-5xctA:
16.71
5unvB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.28A 5unvA-5xctA:
undetectable
5unvB-5xctA:
undetectable		 5unvA-5xctA:
16.71
5unvB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.30A 5unwA-5xctA:
undetectable
5unwB-5xctA:
undetectable		 5unwA-5xctA:
16.71
5unwB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.27A 5unwA-5xctA:
undetectable
5unwB-5xctA:
undetectable		 5unwA-5xctA:
16.71
5unwB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.23A 5unxA-5xctA:
undetectable
5unxB-5xctA:
undetectable		 5unxA-5xctA:
16.71
5unxB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.24A 5unxA-5xctA:
undetectable
5unxB-5xctA:
undetectable		 5unxA-5xctA:
16.71
5unxB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.28A 5unyA-5xctA:
undetectable
5unyB-5xctA:
undetectable		 5unyA-5xctA:
16.71
5unyB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.30A 5unyA-5xctA:
undetectable
5unyB-5xctA:
undetectable		 5unyA-5xctA:
16.71
5unyB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.29A 5unzA-5xctA:
undetectable
5unzB-5xctA:
undetectable		 5unzA-5xctA:
16.71
5unzB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.30A 5uo0A-5xctA:
undetectable
5uo0B-5xctA:
undetectable		 5uo0A-5xctA:
16.71
5uo0B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.28A 5uo3A-5xctA:
undetectable
5uo3B-5xctA:
undetectable		 5uo3A-5xctA:
17.81
5uo3B-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 8 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.30A 5uo7A-5xctA:
undetectable
5uo7B-5xctA:
undetectable		 5uo7A-5xctA:
17.81
5uo7B-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.35A 5vuiA-5xctA:
undetectable
5vuiB-5xctA:
undetectable		 5vuiA-5xctA:
16.71
5vuiB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.35A 5vukA-5xctA:
undetectable
5vukB-5xctA:
undetectable		 5vukA-5xctA:
16.71
5vukB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.35A 5vuqA-5xctA:
undetectable
5vuqB-5xctA:
undetectable		 5vuqA-5xctA:
16.71
5vuqB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.34A 5vusA-5xctA:
undetectable
5vusB-5xctA:
undetectable		 5vusA-5xctA:
16.71
5vusB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.34A 5vusA-5xctA:
undetectable
5vusB-5xctA:
undetectable		 5vusA-5xctA:
16.71
5vusB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.35A 5vuuA-5xctA:
undetectable
5vuuB-5xctA:
undetectable		 5vuuA-5xctA:
16.71
5vuuB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.36A 5vuyA-5xctA:
undetectable
5vuyB-5xctA:
undetectable		 5vuyA-5xctA:
17.81
5vuyB-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.35A 5vuzA-5xctA:
undetectable
5vuzB-5xctA:
undetectable		 5vuzA-5xctA:
17.81
5vuzB-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.33A 5vv0A-5xctA:
undetectable
5vv0B-5xctA:
undetectable		 5vv0A-5xctA:
18.29
5vv0B-5xctA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.36A 5vv1A-5xctA:
undetectable
5vv1B-5xctA:
undetectable		 5vv1A-5xctA:
17.81
5vv1B-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.37A 5vv3A-5xctA:
undetectable
5vv3B-5xctA:
undetectable		 5vv3A-5xctA:
17.81
5vv3B-5xctA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.32A 6auqA-5xctA:
undetectable
6auqB-5xctA:
undetectable		 6auqA-5xctA:
17.07
6auqB-5xctA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.29A 6auqA-5xctA:
undetectable
6auqB-5xctA:
undetectable		 6auqA-5xctA:
17.07
6auqB-5xctA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A  37
TRP A  47
PHE A  69
GLU A  95
 None
 1.33A 6auxA-5xctA:
undetectable
6auxB-5xctA:
undetectable		 6auxA-5xctA:
17.07
6auxB-5xctA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.31A 6auxA-5xctA:
undetectable
6auxB-5xctA:
undetectable		 6auxA-5xctA:
17.07
6auxB-5xctA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xct VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  69
GLU A  95
VAL A  37
TRP A  47
 None
 1.38A 6av2A-5xctA:
undetectable
6av2B-5xctA:
undetectable		 6av2A-5xctA:
18.29
6av2B-5xctA:
18.29