SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		7 / 12 TYR B  36
GLN B  89
LEU B  96
PHE B  98
VAL A  37
ALA A  93
TRP A 103
 None
 0.79A 1h8sA-5xcuB:
20.1		 1h8sA-5xcuB:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5xcu VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 LEU B  73
TRP B  50
TYR B  36
 None
 1.02A 3aicF-5xcuB:
undetectable		 3aicF-5xcuB:
12.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5xcu VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 TYR B  36
GLN B  89
LEU B  96
PHE B  98
 None
 0.39A 3ls4L-5xcuB:
20.3		 3ls4L-5xcuB:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xcu VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 SER B  30
GLY B  30
GLN B  30
 None
 0.37A 3v4tH-5xcuB:
undetectable		 3v4tH-5xcuB:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU A  11
VAL A  12
PRO A  14
LYS B 148
 None
 1.10A 4lb2A-5xcuA:
undetectable		 4lb2A-5xcuA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLU B  55
TYR B  36
THR B  34
TYR A 102
 None
 1.23A 4qwpA-5xcuB:
undetectable		 4qwpA-5xcuB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLU B  55
TYR B  36
THR B  34
TYR A 102
 None
 1.22A 4qwpB-5xcuB:
undetectable		 4qwpB-5xcuB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.06A 4w5oA-5xcuA:
undetectable		 4w5oA-5xcuA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.08A 4z4hA-5xcuA:
undetectable		 4z4hA-5xcuA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.71A 5ecmD-5xcuA:
undetectable		 5ecmD-5xcuA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 7 ALA A  88
THR A  87
VAL A 109
GLU A  85
 None
 0.83A 5ecoD-5xcuA:
undetectable		 5ecoD-5xcuA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.08A 5ki6A-5xcuA:
undetectable		 5ki6A-5xcuA:
11.02