SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5xcx VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus) 		6 / 12 TYR B  36
GLN B  89
LEU B  96
PHE B  98
VAL A  37
TRP A 103
 None
 0.61A 1h8sA-5xcxB:
21.1		 1h8sA-5xcxB:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5xcx VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 5 ILE B  29
SER B  52
ARG B  50
LEU B  33
 None
 0.98A 1y0xX-5xcxB:
undetectable		 1y0xX-5xcxB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5xcx VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 8 HIS B  34
ILE B  29
VAL B  25
VAL B   4
 None
 0.80A 3fi0B-5xcxB:
undetectable		 3fi0B-5xcxB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5xcx VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 8 HIS B  34
ILE B  29
VAL B  25
VAL B   4
 None
 0.76A 3fi0G-5xcxB:
undetectable		 3fi0G-5xcxB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5xcx VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus) 		4 / 8 HIS B  34
ILE B  29
VAL B  25
VAL B   4
 None
 0.76A 3fi0Q-5xcxB:
undetectable		 3fi0Q-5xcxB:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5xcx VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus) 		5 / 5 TYR B  36
GLN B  89
ILE B  94
LEU B  96
PHE B  98
 None
None
CXS  A 204 ( 4.9A)
None
None
 0.31A 3ls4L-5xcxB:
23.2		 3ls4L-5xcxB:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5xcx VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A  94
HIS A 102
TYR A  32
 None
PO4  A 203 (-3.8A)
None
 1.16A 4fu8A-5xcxA:
undetectable		 4fu8A-5xcxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5xcx VH(S112C)-SARAH
CHIMERA
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A  94
HIS A 102
TYR A  32
 None
PO4  A 203 (-3.8A)
None
 1.17A 4fu9A-5xcxA:
undetectable		 4fu9A-5xcxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5xcx VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)
CHIMERA
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		5 / 12 GLN B 143
GLY A   9
SER A 108
THR A 110
SER A  21
 None
 1.21A 5hfjB-5xcxB:
undetectable		 5hfjB-5xcxB:
20.96