SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 9 LEU A 130
ILE A 163
LEU A 143
VAL A 253
ALA A 211
 None
 1.26A 1e7aA-5xcyA:
undetectable		 1e7aA-5xcyA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 7 TYR A 142
THR A 153
THR A 155
VAL A 159
 None
 1.21A 1tv8B-5xcyA:
4.8		 1tv8B-5xcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 ILE A 163
TYR A 190
PHE A 180
ALA A 134
GLU A 214
 None
 1.41A 2vppA-5xcyA:
undetectable		 2vppA-5xcyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 ILE A 163
TYR A 190
PHE A 180
ALA A 134
GLU A 214
 None
 1.43A 2vppB-5xcyA:
undetectable		 2vppB-5xcyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		3 / 3 ARG A 347
ASP A 412
ASN A 362
 None
 0.89A 2zzmA-5xcyA:
undetectable		 2zzmA-5xcyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 6 PHE A 380
PHE A 341
LEU A 294
PHE A 278
 None
 1.15A 3ablP-5xcyA:
undetectable
3ablW-5xcyA:
undetectable		 3ablP-5xcyA:
19.83
3ablW-5xcyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		3 / 3 ASN A  85
ASP A 338
GLN A 333
 None
 0.72A 3eeyC-5xcyA:
undetectable		 3eeyC-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 THR A 296
GLY A 260
GLY A 293
ASN A 297
LEU A 265
 None
 1.20A 3eeyD-5xcyA:
undetectable		 3eeyD-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		3 / 3 ASN A  85
ASP A 338
GLN A 333
 None
 0.71A 3eeyD-5xcyA:
undetectable		 3eeyD-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		3 / 3 ASN A  85
ASP A 338
GLN A 333
 None
 0.71A 3eeyE-5xcyA:
undetectable		 3eeyE-5xcyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 11 TYR A 190
PHE A 180
VAL A 133
ILE A 136
ILE A 161
 None
 1.42A 3o5rA-5xcyA:
undetectable		 3o5rA-5xcyA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 6 ILE A 213
LEU A 245
TYR A 190
THR A 236
 None
 1.09A 3wg7A-5xcyA:
undetectable
3wg7J-5xcyA:
undetectable		 3wg7A-5xcyA:
19.62
3wg7J-5xcyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 6 THR A 340
GLY A 293
ILE A 291
LEU A 332
 None
 1.20A 4ac9C-5xcyA:
3.4		 4ac9C-5xcyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 6 THR A 340
GLY A 293
ILE A 291
LEU A 332
 None
 1.21A 4acaC-5xcyA:
2.9		 4acaC-5xcyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 428
PHE A 368
ALA A 435
LEU A 114
 None
 1.04A 4ejgA-5xcyA:
undetectable		 4ejgA-5xcyA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 8 PHE A 428
VAL A 102
LEU A 439
TYR A  98
 None
 1.14A 4f5zA-5xcyA:
undetectable		 4f5zA-5xcyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 7 GLY A 390
GLY A 391
TYR A 427
ASN A 362
 None
 0.98A 4fgkB-5xcyA:
2.4		 4fgkB-5xcyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 GLY A 367
ILE A 363
ALA A 414
PHE A 428
ASP A 394
 None
 1.11A 4kicB-5xcyA:
undetectable		 4kicB-5xcyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 TYR A 190
PHE A 180
VAL A 133
ILE A 136
ILE A 161
 None
 1.29A 4nnrA-5xcyA:
undetectable
4nnrB-5xcyA:
undetectable		 4nnrA-5xcyA:
15.04
4nnrB-5xcyA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 10 TYR A 190
PHE A 180
VAL A 133
ILE A 136
ILE A 161
 None
 1.28A 4nnrB-5xcyA:
undetectable		 4nnrB-5xcyA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 GLU A 214
ASP A 258
LEU A 294
ALA A 274
ASP A 170
 None
 1.04A 4xe5A-5xcyA:
undetectable		 4xe5A-5xcyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 6 ILE A 384
GLN A 345
ILE A 322
ASP A 320
 None
 1.20A 4z4cA-5xcyA:
undetectable		 4z4cA-5xcyA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 7 TYR A  97
SER A  95
TYR A  98
GLU A 101
 None
 1.12A 5aclA-5xcyA:
undetectable		 5aclA-5xcyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 ILE A 161
ILE A 163
LEU A 130
ALA A 199
VAL A 253
 None
 1.18A 5km9B-5xcyA:
undetectable		 5km9B-5xcyA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 8 TYR A 256
TRP A  87
TYR A 254
LEU A 158
 None
 1.48A 5kxiA-5xcyA:
undetectable
5kxiB-5xcyA:
undetectable		 5kxiA-5xcyA:
21.56
5kxiB-5xcyA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 8 TYR A 256
TRP A  87
TYR A 254
LEU A 158
 None
 1.48A 5kxiD-5xcyA:
undetectable
5kxiE-5xcyA:
undetectable		 5kxiD-5xcyA:
21.56
5kxiE-5xcyA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		3 / 3 GLY A 349
ASN A 436
ARG A 371
 None
 0.80A 5w7bD-5xcyA:
3.3		 5w7bD-5xcyA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 ILE A 291
GLY A 293
VAL A 241
ILE A 213
LEU A 328
 None
 1.03A 5ycnA-5xcyA:
undetectable		 5ycnA-5xcyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		5 / 12 GLY A 178
ASP A 170
ILE A 182
SER A 132
VAL A 133
 None
 1.02A 6mhtA-5xcyA:
undetectable		 6mhtA-5xcyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xcy GLUCANASE
(Phanerochaete
chrysosporium) 		4 / 6 ILE A 213
LEU A 245
TYR A 190
THR A 236
 None
 1.06A 6nmfN-5xcyA:
undetectable
6nmfW-5xcyA:
undetectable		 6nmfN-5xcyA:
19.62
6nmfW-5xcyA:
10.00