SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xd2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLN A 202
THR A 300
TYR A 315
GLN A 195
 None
None
GOL  A 403 (-4.8A)
None
 1.47A 1eiiA-5xd2A:
undetectable		 1eiiA-5xd2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A  73
LEU A  68
GLU A  84
ALA A  79
LEU A  92
 None
 1.27A 2azqA-5xd2A:
undetectable		 2azqA-5xd2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A  73
LEU A  68
GLU A  84
HIS A  83
ALA A  79
 None
 1.08A 2azqA-5xd2A:
undetectable		 2azqA-5xd2A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A 315
ARG A 296
GLY A 298
LYS A 297
 GOL  A 403 (-4.8A)
None
None
ATP  A 402 (-2.8A)
 1.23A 2i30A-5xd2A:
undetectable		 2i30A-5xd2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 240
THR A 241
ILE A 223
HIS A 220
 None
 1.09A 2jfaB-5xd2A:
undetectable		 2jfaB-5xd2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 275
TYR A 315
ARG A 296
GLY A 298
 None
GOL  A 403 (-4.8A)
None
None
 1.10A 3b9mA-5xd2A:
undetectable		 3b9mA-5xd2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  28
GLY A  66
LEU A  63
GLU A  74
ALA A  78
 None
5FA  A 401 (-3.4A)
None
GOL  A 403 ( 4.5A)
None
 1.16A 3kkzA-5xd2A:
undetectable		 3kkzA-5xd2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5xd2 NUDIX FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PRO A 276
ARG A 169
GLY A 298
PRO A 318
 None
ATP  A 402 (-3.7A)
None
None
 1.38A 3ucbB-5xd2A:
undetectable		 3ucbB-5xd2A:
15.17