SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xd6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 9 GLY A  76
VAL A  83
ALA A  95
TYR A 143
ALA A 144
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
ANP  A1000 (-3.5A)
ANP  A1000 (-4.5A)
0.76A 1muoA-5xd6A:
19.7
1muoA-5xd6A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 11 LEU A 168
ALA A 213
LEU A 206
SER A 148
LEU A 149
None
None
ANP  A1000 (-4.5A)
ANP  A1000 ( 4.4A)
None
1.29A 2c12F-5xd6A:
undetectable
2c12F-5xd6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
8 / 11 GLY A  76
GLY A  78
VAL A  83
ALA A  95
TYR A 143
ALA A 144
SER A 148
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-3.3A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
ANP  A1000 (-3.5A)
ANP  A1000 ( 4.4A)
ANP  A1000 (-4.5A)
0.65A 2evaA-5xd6A:
23.7
2evaA-5xd6A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 LEU A 308
ASP A 305
GLY A 272
GLY A 165
ILE A 152
None
0.94A 2pynA-5xd6A:
undetectable
2pynA-5xd6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 LEU A 308
ASP A 305
GLY A 272
GLY A 165
ILE A 152
None
0.93A 2q64A-5xd6A:
undetectable
2q64A-5xd6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 10 ILE A 176
PHE A 262
LEU A 320
VAL A 323
LEU A 266
None
1.31A 2w98A-5xd6A:
undetectable
2w98A-5xd6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 GLY A  76
VAL A  83
ALA A  95
TYR A 143
GLY A 147
ALA A 216
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
None
MG  A1001 ( 4.4A)
0.75A 2wgjA-5xd6A:
23.6
2wgjA-5xd6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 4 ARG A  82
GLY A  78
GLU A  77
SER A 221
None
ANP  A1000 (-3.3A)
None
None
1.13A 2xctS-5xd6A:
3.0
2xctU-5xd6A:
2.8
2xctS-5xd6A:
8.36
2xctU-5xd6A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 10 ILE A  75
VAL A  83
ALA A  95
GLY A 147
ASP A 151
LEU A 206
ANP  A1000 (-4.2A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 ( 4.9A)
ANP  A1000 (-4.5A)
0.87A 2y7jC-5xd6A:
14.8
2y7jC-5xd6A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 10 ILE A  75
VAL A  83
ALA A  95
GLY A 147
ASP A 151
LEU A 206
ANP  A1000 (-4.2A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 ( 4.9A)
ANP  A1000 (-4.5A)
0.82A 2y7jD-5xd6A:
14.6
2y7jD-5xd6A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 11 LEU A 308
ASP A 305
GLY A 272
GLY A 165
ILE A 152
None
1.01A 3ebzB-5xd6A:
undetectable
3ebzB-5xd6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 ILE A 215
LEU A 266
GLU A 185
PRO A 336
ASN A 337
None
1.23A 3eigA-5xd6A:
undetectable
3eigA-5xd6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
8 / 12 VAL A  83
ALA A  95
LYS A  97
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ALA A 216
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
0.71A 3g5dB-5xd6A:
22.7
3g5dB-5xd6A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 LEU A 308
ASP A 305
GLY A 272
GLY A 165
ILE A 152
None
0.96A 3ndtC-5xd6A:
undetectable
3ndtC-5xd6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 LEU A 308
ASP A 305
GLY A 272
GLY A 165
ILE A 152
None
0.97A 3nduC-5xd6A:
undetectable
3nduC-5xd6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 VAL A  83
ALA A  95
LYS A  97
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
0.61A 3octA-5xd6A:
6.7
3octA-5xd6A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 VAL A  83
ALA A  95
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ALA A 216
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
0.72A 3oezA-5xd6A:
22.6
3oezA-5xd6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 8 VAL A 124
VAL A 125
LEU A 206
ILE A 215
None
None
ANP  A1000 (-4.5A)
None
0.63A 3wzeA-5xd6A:
22.7
3wzeA-5xd6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 LEU A 184
LEU A 187
ILE A 196
GLN A 223
ILE A 200
None
1.07A 4a7aB-5xd6A:
undetectable
4a7aB-5xd6A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 6 ILE A 215
PHE A 262
HIS A 150
VAL A 287
None
1.22A 4a97I-5xd6A:
undetectable
4a97I-5xd6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 9 LEU A 308
ASP A 305
GLY A 272
GLY A 165
ILE A 152
None
1.05A 4dqcB-5xd6A:
undetectable
4dqcB-5xd6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 GLY A  76
VAL A  83
ALA A  95
LYS A  97
LEU A 127
LEU A 139
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
None
ANP  A1000 (-4.5A)
0.63A 4ifgA-5xd6A:
20.6
4ifgA-5xd6A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 GLY A  76
VAL A  83
LYS A  97
LEU A 127
LEU A 139
GLY A 147
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
None
None
ANP  A1000 (-4.5A)
0.51A 4ifgA-5xd6A:
20.6
4ifgA-5xd6A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 VAL A  83
ALA A  95
LYS A  97
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
0.68A 4mxxB-5xd6A:
22.4
4mxxB-5xd6A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 4 ALA A 318
ALA A 321
ALA A 322
ALA A 325
None
0.10A 4oadA-5xd6A:
undetectable
4oadA-5xd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 4 ALA A 318
ALA A 321
ALA A 322
ALA A 325
None
0.10A 4oaeA-5xd6A:
undetectable
4oaeA-5xd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 VAL A  83
LYS A  97
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ALA A 216
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
0.58A 4otwA-5xd6A:
23.9
4otwA-5xd6A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 ILE A  75
GLY A  76
VAL A  83
ALA A  95
TYR A 143
LEU A 206
ANP  A1000 (-4.2A)
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
ANP  A1000 (-4.5A)
0.72A 4qmzA-5xd6A:
12.4
4qmzA-5xd6A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 HIS A 197
ALA A 213
ALA A 216
VAL A 205
GLY A 183
GLY A 179
None
None
MG  A1001 ( 4.4A)
None
None
None
1.46A 4rn6B-5xd6A:
undetectable
4rn6B-5xd6A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 8 TYR A 143
ARG A 198
LEU A 206
ILE A 215
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
None
0.70A 4v04A-5xd6A:
21.6
4v04A-5xd6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 ALA A  95
ALA A 144
LEU A 187
HIS A 197
ALA A 216
ANP  A1000 (-3.2A)
ANP  A1000 (-3.5A)
None
None
MG  A1001 ( 4.4A)
0.83A 4v04B-5xd6A:
21.9
4v04B-5xd6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 VAL A  83
ALA A  95
LYS A  97
VAL A 125
GLY A 147
LEU A 206
ALA A 216
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
0.65A 4xeyB-5xd6A:
22.8
4xeyB-5xd6A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 5 SER A 221
ARG A  82
GLY A  78
GLU A  77
None
None
ANP  A1000 (-3.3A)
None
0.98A 5cdqA-5xd6A:
3.1
5cdqB-5xd6A:
undetectable
5cdqC-5xd6A:
3.3
5cdqA-5xd6A:
12.74
5cdqB-5xd6A:
15.98
5cdqC-5xd6A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 5 SER A 221
ARG A  82
GLY A  78
GLU A  77
None
None
ANP  A1000 (-3.3A)
None
1.00A 5cdqR-5xd6A:
3.3
5cdqS-5xd6A:
undetectable
5cdqT-5xd6A:
2.2
5cdqR-5xd6A:
12.74
5cdqS-5xd6A:
15.98
5cdqT-5xd6A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
4 / 4 CYH A 303
LEU A 295
LEU A 270
ALA A 324
None
0.92A 5hpuA-5xd6A:
undetectable
5hpuB-5xd6A:
undetectable
5hpuA-5xd6A:
undetectable
5hpuB-5xd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 ILE A  75
ALA A  95
LYS A  97
TYR A 143
GLY A 147
LEU A 206
ANP  A1000 (-4.2A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
0.66A 5i9yA-5xd6A:
23.5
5i9yA-5xd6A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
3 / 3 GLY A 272
ASP A 305
ASN A 309
None
0.50A 5jglA-5xd6A:
undetectable
5jglA-5xd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
7 / 12 ILE A  75
GLY A  76
VAL A  83
ALA A  95
VAL A 125
LEU A 206
ALA A 216
ANP  A1000 (-4.2A)
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
0.98A 5l2tA-5xd6A:
6.3
5l2tA-5xd6A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 11 VAL A  83
ALA A  95
VAL A 125
TYR A 143
ALA A 144
LEU A 206
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 (-4.3A)
ANP  A1000 (-3.5A)
ANP  A1000 (-4.5A)
0.59A 5lvnA-5xd6A:
19.0
5lvnA-5xd6A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 ILE A  75
GLY A  76
ALA A  95
TYR A 143
GLY A 147
ASP A 151
ANP  A1000 (-4.2A)
ANP  A1000 ( 3.8A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
None
ANP  A1000 ( 4.9A)
0.84A 5vc3A-5xd6A:
20.3
5vc3A-5xd6A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 GLY A  76
VAL A  83
ALA A  95
LYS A  97
LEU A 139
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.5A)
0.70A 5yu9B-5xd6A:
23.9
5yu9B-5xd6A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
6 / 12 GLY A  76
VAL A  83
LYS A  97
LEU A 139
ASP A 151
LEU A 206
ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
ANP  A1000 ( 4.9A)
ANP  A1000 (-4.5A)
0.59A 5yu9B-5xd6A:
23.9
5yu9B-5xd6A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana)
5 / 12 VAL A  83
LYS A  97
LEU A 139
GLY A 147
ASP A 151
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
None
ANP  A1000 ( 4.9A)
0.75A 5yu9C-5xd6A:
23.7
5yu9C-5xd6A:
29.21