SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 8 SER A 162
VAL A 215
GLY A 200
GLY A 213
 None
 0.73A 1f5lA-5xdeA:
undetectable		 1f5lA-5xdeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 6 ALA A 186
SER A 212
TRP A 122
LEU A 228
 None
FMN  A 501 ( 3.3A)
None
None
 1.08A 1gahA-5xdeA:
undetectable		 1gahA-5xdeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 8 ASP A 177
ARG A 183
GLY A 229
GLY A 148
 None
 0.81A 1jr1B-5xdeA:
undetectable		 1jr1B-5xdeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 7 SER A 278
ALA A 362
TYR A 299
SER A 276
 None
 1.06A 1k5qA-5xdeA:
0.7
1k5qB-5xdeA:
undetectable		 1k5qA-5xdeA:
19.81
1k5qB-5xdeA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 6 ASN A  97
HIS A  89
TYR A  93
GLY A 161
 None
FMN  A 501 (-3.5A)
FMN  A 501 (-3.9A)
None
 1.49A 1mxdA-5xdeA:
undetectable		 1mxdA-5xdeA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		5 / 12 ALA A  81
ALA A 313
ALA A 317
ILE A 254
LEU A  57
 None
 1.20A 2nyrA-5xdeA:
undetectable		 2nyrA-5xdeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		5 / 9 ALA A  85
ASP A  84
GLY A 206
VAL A 352
ILE A 262
 None
 1.00A 3em4B-5xdeA:
undetectable		 3em4B-5xdeA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		5 / 9 ALA A  85
ASP A  84
GLY A 206
VAL A 352
ILE A 262
 None
 1.03A 3ndwB-5xdeA:
undetectable		 3ndwB-5xdeA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		5 / 12 GLY A  92
ASN A  97
ALA A  78
ALA A  81
LEU A 258
 None
 1.05A 3p2kA-5xdeA:
undetectable		 3p2kA-5xdeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 7 TYR A  93
HIS A 388
TRP A 247
MET A 338
 FMN  A 501 (-3.9A)
FMN  A 501 (-3.2A)
None
None
 1.30A 3uzzA-5xdeA:
undetectable		 3uzzA-5xdeA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 8 TYR A  93
HIS A 388
TRP A 247
MET A 338
 FMN  A 501 (-3.9A)
FMN  A 501 (-3.2A)
None
None
 1.25A 3uzzB-5xdeA:
undetectable		 3uzzB-5xdeA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		3 / 3 ARG A 319
GLU A 332
ARG A 326
 SO4  A 503 (-2.9A)
None
SO4  A 503 (-3.0A)
 0.87A 4mwvA-5xdeA:
undetectable		 4mwvA-5xdeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		5 / 10 ALA A 382
LEU A 258
ALA A  85
SER A 204
LEU A 205
 None
 0.85A 4zbrA-5xdeA:
3.6		 4zbrA-5xdeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		3 / 3 PRO A  42
LEU A  24
SER A  86
 None
 0.62A 5fsaB-5xdeA:
undetectable		 5fsaB-5xdeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 6 SER A 212
HIS A  89
HIS A 388
TYR A  93
 FMN  A 501 ( 3.3A)
FMN  A 501 (-3.5A)
FMN  A 501 (-3.2A)
FMN  A 501 (-3.9A)
 1.05A 5ycnA-5xdeA:
undetectable		 5ycnA-5xdeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C
(Paenibacillus
sp.
A11-2) 		4 / 4 HIS A 257
VAL A 341
LEU A 253
ALA A 313
 None
 1.00A 6d8pB-5xdeA:
undetectable		 6d8pB-5xdeA:
21.90